2021
Impact of Low-Dose Fluconazole on Tacrolimus Dosing in Renal Transplant
Johnston JP, Cohen EA, Casal GH, Asch WS, Reardon DP. Impact of Low-Dose Fluconazole on Tacrolimus Dosing in Renal Transplant. Journal Of Pharmacy Practice 2021, 35: 701-706. PMID: 33759619, DOI: 10.1177/08971900211000702.Peer-Reviewed Original ResearchConceptsLow-dose fluconazoleRenal transplant patientsAdverse drug reactionsTAC levelsTransplant patientsGraft rejectionDrug reactionsTherapeutic levelsSingle-center retrospective chart reviewPost-operative day 10Azole antifungal therapySubtherapeutic tacrolimus levelsTAC dose adjustmentRenal transplant recipientsTotal daily doseRetrospective chart reviewTacrolimus dosingTacrolimus levelsRenal transplantTransplant recipientsChart reviewSecondary outcomesDaily doseDose adjustmentPrimary outcome
2020
Clinical Implications of Unique Drug Interaction Between Extended Release Tacrolimus and Phenytoin
Harkness TM, Cohen EA, Asch WS, Belfield KD. Clinical Implications of Unique Drug Interaction Between Extended Release Tacrolimus and Phenytoin. Progress In Transplantation 2020, 30: 177-178. PMID: 32233829, DOI: 10.1177/1526924820913500.Peer-Reviewed Original Research
2018
New England BK consortium: Regional survey of BK screening and management protocols in comparison to published consensus guidelines
Gabardi S, Pavlakis M, Tan C, Francis J, Cardarelli F, Asch W, Bodziak K, Chobanian M, Gilligan H, Gohh R, Kung S, Inker L, Martin S, Rodig N, Rossi A, Chandraker A. New England BK consortium: Regional survey of BK screening and management protocols in comparison to published consensus guidelines. Transplant Infectious Disease 2018, 20: e12985. PMID: 30175491, DOI: 10.1111/tid.12985.Peer-Reviewed Original ResearchConceptsRenal transplant recipientsConsensus guidelinesBKPyV-associated nephropathyCNI dose reductionPlasma viral loadUse of leflunomideCopies/mLHalf of centersMajority of centersManagement protocolCause biopsiesImmunosuppression reductionIntravenous immunoglobulinTransplant recipientsRenal biopsyViral loadBK polyomavirusPrimary treatmentDose reductionBiopsyUniform screeningNephropathyBKPyVShort durationScreening