2012
GDP-Mannose-4,6-Dehydratase Is a Cytosolic Partner of Tankyrase 1 That Inhibits Its Poly(ADP-Ribose) Polymerase Activity
Bisht KK, Dudognon C, Chang WG, Sokol ES, Ramirez A, Smith S. GDP-Mannose-4,6-Dehydratase Is a Cytosolic Partner of Tankyrase 1 That Inhibits Its Poly(ADP-Ribose) Polymerase Activity. Molecular And Cellular Biology 2012, 32: 3044-3053. PMID: 22645305, PMCID: PMC3434517, DOI: 10.1128/mcb.00258-12.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, NuclearCell Cycle ProteinsCell LineHeLa CellsHumansHydro-LyasesNuclear Matrix-Associated ProteinsRNA InterferenceRNA, Small InterferingSpindle ApparatusTankyrasesTelomeric Repeat Binding Protein 1
2007
Protein requirements for sister telomere association in human cells
Canudas S, Houghtaling BR, Kim JY, Dynek JN, Chang WG, Smith S. Protein requirements for sister telomere association in human cells. The EMBO Journal 2007, 26: 4867-4878. PMID: 17962804, PMCID: PMC2099466, DOI: 10.1038/sj.emboj.7601903.Peer-Reviewed Original ResearchCell Cycle ProteinsCentrifugation, Density GradientChromosomal Proteins, Non-HistoneGene Expression Regulation, NeoplasticHeLa CellsHumansImmunoprecipitationIn Situ Hybridization, FluorescenceMitosisModels, BiologicalNuclear ProteinsPoly(ADP-ribose) PolymerasesProtein BindingTankyrasesTelomereTelomere-Binding ProteinsTelomeric Repeat Binding Protein 1
2004
A Dynamic Molecular Link between the Telomere Length Regulator TRF1 and the Chromosome End Protector TRF2
Houghtaling BR, Cuttonaro L, Chang W, Smith S. A Dynamic Molecular Link between the Telomere Length Regulator TRF1 and the Chromosome End Protector TRF2. Current Biology 2004, 14: 1621-1631. PMID: 15380063, DOI: 10.1016/j.cub.2004.08.052.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceBlotting, NorthernCell CycleFluorescent Antibody TechniqueHeLa CellsHumansImmunoprecipitationModels, BiologicalMolecular Sequence DataPlasmidsSequence Analysis, DNAShelterin ComplexTelomereTelomere-Binding ProteinsTelomeric Repeat Binding Protein 1Telomeric Repeat Binding Protein 2Two-Hybrid System TechniquesConceptsTelomerase-mediated telomere elongationTelomere length homeostasisBinding proteins TRF1Telomere length controlLength homeostasisTelomeric chromatinProteins TRF1Chromosome endsTelomere elongationHuman telomeresTankyrase 1TRF1TRF2Negative regulatorMolecular linkMolecular mechanismsCell cycleTelomeresDynamic cross talkTIN2Cross talkLength controlChromatinRegulatorProtein
2003
TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres
Chang W, Dynek JN, Smith S. TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres. Genes & Development 2003, 17: 1328-1333. PMID: 12782650, PMCID: PMC196064, DOI: 10.1101/gad.1077103.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine Diphosphate RiboseAnimalsBase SequenceCloning, MolecularEndopeptidasesMammalsRecombinant ProteinsTelomereTelomeric Repeat Binding Protein 1UbiquitinConceptsSequential post-translational modificationsAccess of telomeraseDNA-binding proteinsPost-translational modificationsMammalian telomeresTelomeres resultsTranslational modificationsTankyrase 1TRF1Negative regulatorTelomeresADP-ribosylationNovel mechanismUnbound formUbiquitinationTelomere lengthUbiquitinProteasomeTelomeraseRegulatorProteolysisProteinDegradationElongation
2002
Role for the Related Poly(ADP-Ribose) Polymerases Tankyrase 1 and 2 at Human Telomeres
Cook BD, Dynek JN, Chang W, Shostak G, Smith S. Role for the Related Poly(ADP-Ribose) Polymerases Tankyrase 1 and 2 at Human Telomeres. Molecular And Cellular Biology 2002, 22: 332-342. PMID: 11739745, PMCID: PMC134233, DOI: 10.1128/mcb.22.1.332-342.2002.Peer-Reviewed Original ResearchConceptsTankyrase 2Tankyrase 1Telomeric complexTelomeric DNA-binding proteinAccess of telomerasePolymerase tankyrase 1DNA-binding proteinsSpecialized reverse transcriptaseEndogenous TRF1Telomere maintenanceTelomeric functionPrimary human cellsRelated homologsPARP domainTelomeric DNAHuman telomeresTRF1TelomeresHuman cellsADP-ribosylationPARP assaysRecent identificationTelomeraseReverse transcriptaseOverexpression