2016
Incidence of systemic lupus erythematosus in a population-based cohort using revised 1997 American College of Rheumatology and the 2012 Systemic Lupus International Collaborating Clinics classification criteria
Ungprasert P, Sagar V, Crowson C, Amin S, Makol A, Ernste F, Osborn T, Moder K, Niewold T, Maradit-Kremers H, Ramsey-Goldman R, Chowdhary V. Incidence of systemic lupus erythematosus in a population-based cohort using revised 1997 American College of Rheumatology and the 2012 Systemic Lupus International Collaborating Clinics classification criteria. Lupus 2016, 26: 240-247. PMID: 27365370, PMCID: PMC5201452, DOI: 10.1177/0961203316657434.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusACR-97SLICC-12Lupus erythematosusSystemic Lupus International Collaborating Clinics classification criteriaSystemic Lupus International Collaborating Clinics (SLICC) groupClassification criteriaIncidence of lupusIncident SLE patientsRenal-limited diseaseSLICC-12 criteriaRochester Epidemiology ProjectACR classification criteriaPopulation-based cohortOlmsted CountyMedian durationSLE patientsAdjusted incidenceAmerican CollegeClinic groupHigh incidenceImmunologic criteriaNeurologic criteriaPatientsIncidence
2015
Autoimmune myelofibrosis with pancytopenia as a presenting manifestation of systemic lupus erythematosus responsive to mycophenolate mofetil
Ungprasert P, Chowdhary V, Davis M, Makol A. Autoimmune myelofibrosis with pancytopenia as a presenting manifestation of systemic lupus erythematosus responsive to mycophenolate mofetil. Lupus 2015, 25: 427-430. PMID: 26537421, DOI: 10.1177/0961203315615221.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusAutoimmune myelofibrosisLupus erythematosusBullous skin lesionsPresenting manifestationPeripheral destructionHematological abnormalitiesSkin lesionsMofetilErythematosusPancytopeniaMyelofibrosisManifestationsLeucopeniaThrombocytopeniaAnemiaGlucocorticoidsLesionsAbnormalitiesID: 209 Single cell interferon signatures in lupus patient monocytes reveal a differential impact of interferon signaling between monocyte subtypes
Jin Z, Fan W, Jensen M, Dorschner J, Vsetecka D, Amin S, Makol A, Ernste F, Osborn T, Moder K, Chowdhary V, Niewold T. ID: 209 Single cell interferon signatures in lupus patient monocytes reveal a differential impact of interferon signaling between monocyte subtypes. Cytokine 2015, 76: 102-103. DOI: 10.1016/j.cyto.2015.08.213.Peer-Reviewed Original ResearchSystemic lupus erythematosusHigher IFN scoresClassical monocytesIFN scoreI interferonPatients' monocytesCD16 expressionEffects of IFNHuman systemic lupus erythematosusNon-classical subtypesPrimary pathogenic factorImmune cell populationsNon-classical monocytesCell populationsSingle immune cellsType I interferonPatient blood samplesSLE patientsLupus erythematosusMonocyte subtypesInflammatory mediatorsIFN signatureImmune cellsPathogenic factorsBlood samplesAB0539 Risk of Cardiovascular Events in Patients with Cutaneous Lupus Erythematosus: A Population-Based Study
Singh A, Crowson C, Davis M, Maradit-Kremers H, Matteson E, Chowdhary V. AB0539 Risk of Cardiovascular Events in Patients with Cutaneous Lupus Erythematosus: A Population-Based Study. Annals Of The Rheumatic Diseases 2015, 74: 1080. DOI: 10.1136/annrheumdis-2015-eular.4318.Peer-Reviewed Original ResearchCutaneous lupus erythematosusSystemic lupus erythematosusPopulation-based cohortCardiovascular eventsCardiovascular diseaseLupus erythematosusCumulative incidenceRisk factorsDiagnosis of CLESubtypes of CLERisk of CVDPositive antinuclear antibodyIndependent risk factorSex-matched subjectsKaplan-Meier methodMedical record reviewSex-matched cohortChronic inflammatory diseaseSex-matched controlsComplex gene-environment interactionsMedian ESRAntinuclear antibodiesSystemic inflammationRecord reviewMyocardial infarctionTHU0329 Risk of Cancer is not Increased in Patients with Cutaneous Lupus Erythematosus: A Population-Based Study
Singh A, Crowson C, Davis M, Maradit-Kremers H, Matteson E, Chowdhary V. THU0329 Risk of Cancer is not Increased in Patients with Cutaneous Lupus Erythematosus: A Population-Based Study. Annals Of The Rheumatic Diseases 2015, 74: 314. DOI: 10.1136/annrheumdis-2015-eular.4320.Peer-Reviewed Original ResearchCutaneous lupus erythematosusSystemic lupus erythematosusPopulation-based cohortNon-melanoma skin cancerSex-matched subjectsRisk of malignancyLupus erythematosusIndex dateCumulative incidenceDiagnosis of CLESubtypes of CLESkin cancerSystemic immune dysregulationPositive antinuclear antibodyChronic autoimmune diseaseKaplan-Meier methodMedical record reviewSex-matched cohortCLE subjectsImmunomodulatory medicationsMedian ESRCLE patientsDiagnosis dateAntinuclear antibodiesImmune dysregulationTHU0372 Incidence of Systemic Lupus Erythematosus (SLE) in a Population Based Cohort Using 1982, Revised 1997 ACR and 2012 SLICC Criteria
Sagar V, Crowson C, Amin S, Makol A, Ernste F, Osborn T, Moder K, Niewold T, Maradit-Kremers H, Chowdhary V. THU0372 Incidence of Systemic Lupus Erythematosus (SLE) in a Population Based Cohort Using 1982, Revised 1997 ACR and 2012 SLICC Criteria. Annals Of The Rheumatic Diseases 2015, 74: 330. DOI: 10.1136/annrheumdis-2015-eular.4180.Peer-Reviewed Original ResearchSystemic lupus erythematosusIncidence of SLESLICC criteriaACR criteriaLupus erythematosusSystemic Lupus International Collaborating Clinics (SLICC) criteriaIncident SLE casesDrug-induced lupusSLE classification criteriaSystemic autoimmune diseasePopulation Based CohortUS white populationClassification criteriaHeterogeneous clinical phenotypesClinic criteriaCutaneous lupusPositive ANASLE criteriaOverall incidenceIncident casesPhysician diagnosisAutoimmune diseasesSLE casesMale ratioAmerican CollegeTHU0022 Single Cell Interferon Signatures in Lupus Patient Monocytes Reveal a Differential Impact of Interferon Signaling Between Monocyte Subtypes
Jin Z, Fan W, Jensen M, Dorschner J, Vsetecka D, Amin S, Makol A, Ernste F, Osborn T, Moder K, Chowdhary V, Niewold T. THU0022 Single Cell Interferon Signatures in Lupus Patient Monocytes Reveal a Differential Impact of Interferon Signaling Between Monocyte Subtypes. Annals Of The Rheumatic Diseases 2015, 74: 200. DOI: 10.1136/annrheumdis-2015-eular.5326.Peer-Reviewed Original ResearchSystemic lupus erythematosusHigher IFN scoresClassical monocytesIFN scoreI interferonSLE patientsCD16 expressionEffects of IFNHuman systemic lupus erythematosusNon-classical subtypesPrimary pathogenic factorImmune cell populationsNon-classical monocytesCell populationsSingle immune cellsType I interferonPatient blood samplesLupus erythematosusMonocyte subtypesInflammatory mediatorsInterferon signatureIndividual monocytesPatients' monocytesIFN signatureImmune cellsEpidemiology of Systemic Lupus Erythematosus and Cutaneous Lupus Erythematosus in a Predominantly White Population in the United States
Jarukitsopa S, Hoganson DD, Crowson CS, Sokumbi O, Davis MD, Michet CJ, Matteson EL, Maradit Kremers H, Chowdhary VR. Epidemiology of Systemic Lupus Erythematosus and Cutaneous Lupus Erythematosus in a Predominantly White Population in the United States. Arthritis Care & Research 2015, 67: 817-828. PMID: 25369985, PMCID: PMC4418944, DOI: 10.1002/acr.22502.Peer-Reviewed Original ResearchConceptsCutaneous lupus erythematosusSystemic lupus erythematosusSex-adjusted incidenceLupus erythematosusPrevalence of SLEClassic discoid lupus erythematosusBullous lupus erythematosusRochester Epidemiology ProjectSex-adjusted prevalenceDiscoid lupus erythematosusRheumatology classification criteriaWhite populationUS white populationCLE casesOlmsted CountyLupus panniculitisSLE casesMedical recordsErythematosusEpidemiologic studiesAmerican CollegePrevalenceIncidenceOlder adultsAge
2014
Pregnancy‐related issues in women with systemic lupus erythematosus
Singh AG, Chowdhary VR. Pregnancy‐related issues in women with systemic lupus erythematosus. International Journal Of Rheumatic Diseases 2014, 18: 172-181. PMID: 25545844, DOI: 10.1111/1756-185x.12524.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusActive diseaseLupus erythematosusPregnancy lossHigh-risk obstetric clinicRisk of flareAdverse pregnancy outcomesCongenital heart blockPregnancy-related issuesRecurrent pregnancy lossIntrauterine growth retardationPersonalized treatment strategiesTime of conceptionMaternal hypertensionActive nephritisAntiphospholipid antibodiesFetal outcomesNeonatal lupusPregnant patientsPreterm deliveryPregnancy outcomesPreterm birthHeart blockNeonatal mortalityAdverse outcomesSAT0100 Incidence of Systemic Lupus Erythematosus and Cutaneous Lupus Erythematosuis in A Population Based Cohort from 1993-2005
Chowdhary V, Crowson C, Maradit-Kremers H, Davis M. SAT0100 Incidence of Systemic Lupus Erythematosus and Cutaneous Lupus Erythematosuis in A Population Based Cohort from 1993-2005. Annals Of The Rheumatic Diseases 2014, 73: 626. DOI: 10.1136/annrheumdis-2014-eular.1183.Peer-Reviewed Original ResearchCutaneous lupus erythematosusSystemic lupus erythematosusPopulation-based studyLupus erythematosusOverall incidenceIncidence rateIncidence of SLEIncident systemic lupus erythematosusAge groupsAge-specific incidence ratesIncident SLE casesMajority of patientsOverall incidence rateSLE classification criteriaAge-adjusted incidenceYears age groupConfidence intervalsHeterogeneous clinical manifestationsPopulation Based CohortUS white populationCutaneous lupusOlmsted CountyCutaneous casesDiscoid LESkin rashChronic activation with a staphylococcal superantigen drives the expansion of CD4, CD8 double negative T cells and promotes multiorgan inflammation mimicking systemic lupus erythematosus in HLA class II transgenic mice. (HUM7P.306)
Rajagopalan G, Tilahun A, Chowdhary V. Chronic activation with a staphylococcal superantigen drives the expansion of CD4, CD8 double negative T cells and promotes multiorgan inflammation mimicking systemic lupus erythematosus in HLA class II transgenic mice. (HUM7P.306). The Journal Of Immunology 2014, 192: 184.15-184.15. DOI: 10.4049/jimmunol.192.supp.184.15.Peer-Reviewed Original ResearchSystemic lupus erythematosusDNT cellsT cellsDKO miceLupus erythematosusKnockout miceCD8 coreceptorCD8 double-negative T cellsHLA class II transgenic miceTransgenic miceDouble-negative T cellsHLA-DR3 transgenic miceII transgenic miceRole of superantigensExpansion of CD4Role of CD4Negative T cellsLupus-like diseaseMini-osmotic pumpsPathogenesis of lupusWild-type miceSingle knockout miceDouble knockout miceT cell activationStaphylococcal enterotoxin B
2012
Chronic Exposure to Staphylococcal Superantigen Elicits a Systemic Inflammatory Disease Mimicking Lupus
Chowdhary VR, Tilahun AY, Clark CR, Grande JP, Rajagopalan G. Chronic Exposure to Staphylococcal Superantigen Elicits a Systemic Inflammatory Disease Mimicking Lupus. The Journal Of Immunology 2012, 189: 2054-2062. PMID: 22798666, PMCID: PMC3462343, DOI: 10.4049/jimmunol.1201097.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantibodiesAutoantigensAutoimmune DiseasesCD28 AntigensCD4-Positive T-LymphocytesEnzyme-Linked Immunosorbent AssayFlow CytometryFluorescent Antibody TechniqueHLA-DQ AntigensHumansInfusions, SubcutaneousLupus Erythematosus, SystemicMiceMice, TransgenicStaphylococcus aureusSuperantigensConceptsSystemic lupus erythematosusT cellsChronic exposureStaphylococcal enterotoxin BLupus erythematosusMouse MHC class II moleculesHLA-DQ8 transgenic miceMultisystem autoimmune inflammatory diseaseEnterotoxin BHLA-DQ8 miceAutoimmune inflammatory diseaseMHC class II moleculesTh1-type cytokinesMini-osmotic pumpsMononuclear cell infiltrationAnti-nuclear AbsClass II moleculesAbsence of diseaseChronic nasalIL-12Inflammatory infiltrateAutoimmune diseasesCell infiltrationInflammatory diseasesPathogenic roleIncreased Risk of Systemic Lupus Erythematosus in 29,000 Patients with Biopsy-verified Celiac Disease
Ludvigsson JF, Rubio-Tapia A, Chowdhary V, Murray JA, Simard JF. Increased Risk of Systemic Lupus Erythematosus in 29,000 Patients with Biopsy-verified Celiac Disease. The Journal Of Rheumatology 2012, 39: 1964-1970. PMID: 22859356, PMCID: PMC3463642, DOI: 10.3899/jrheum.120493.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusRisk of SLEHazard ratioCeliac diseaseLupus erythematosusAbsolute riskExcess riskGeneral populationPossible associationBiopsy-verified celiac diseaseIncident systemic lupus erythematosusSweden's 28 pathology departmentsSwedish Total Population RegisterDepartment of RheumatologySwedish Patient RegisterYears of followupPopulation-based studyTotal Population RegisterSimilar risk estimatesSLE diagnosisPatient RegisterCase seriesCox regressionCD diagnosisPathology department
2008
Liver Involvement in Systemic Lupus Erythematosus: Case Review of 40 Patients
Chowdhary VR, Crowson CS, Poterucha JJ, Moder KG. Liver Involvement in Systemic Lupus Erythematosus: Case Review of 40 Patients. The Journal Of Rheumatology 2008, 35: 2159-2164. PMID: 18793002, DOI: 10.3899/jrheum.080336.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusEndstage liver diseaseLiver diseasePortal hypertensionLiver involvementViral hepatitisLupus erythematosusLiver disease-free survivalNonalcoholic fatty liver diseaseCoexistent liver diseaseSubclinical liver involvementDevelopment of cirrhosisLiver enzyme abnormalitiesAlanine aminotransferase levelsDisease-free survivalRetrospective chart reviewCohort of patientsFatty liver diseasePrimary biliary cirrhosisAlkaline phosphatase levelsClinical diagnostic groupsAutoimmune hepatitisCryptogenic cirrhosisHepatitis CAminotransferase levels
2002
HLA Class II Influences the Immune Response and Antibody Diversification to Ro60/Sjögren’s Syndrome-A: Heightened Antibody Responses and Epitope Spreading in Mice Expressing HLA-DR molecules
Paisansinsup T, Deshmukh US, Chowdhary VR, Luthra HS, Fu SM, David CS. HLA Class II Influences the Immune Response and Antibody Diversification to Ro60/Sjögren’s Syndrome-A: Heightened Antibody Responses and Epitope Spreading in Mice Expressing HLA-DR molecules. The Journal Of Immunology 2002, 168: 5876-5884. PMID: 12023392, DOI: 10.4049/jimmunol.168.11.5876.Peer-Reviewed Original ResearchConceptsHLA class II genesImmune responseCell epitopesB-cell epitopesDQ6 miceDQ8 miceSjögren's syndromeClass II genesDominant T cell epitopesMurine class II moleculesSystemic lupus erythematosusHLA class IISera of patientsB cell responsesDominant B-cell epitopesHLA-DR moleculesT cell epitopesClass II moleculesLupus erythematosusAntibody responseDR3 miceCell responsesHigh titersClass IISyndrome