2005
HLA-DQ8 is a predisposing molecule for detergent enzyme subtilisin BPN′-induced hypersensitivity
Xue A, Chapoval SP, Finn ES, Chowdhary VR, Marietta EV, Gaffey TA, Pursifull AC, David CS. HLA-DQ8 is a predisposing molecule for detergent enzyme subtilisin BPN′-induced hypersensitivity. Clinical Immunology 2005, 117: 302-315. PMID: 16185928, DOI: 10.1016/j.clim.2005.08.003.Peer-Reviewed Original ResearchConceptsT cell responsesDQ8 miceCell responsesDR4 transgenic miceStrong susceptibility markerEosinophilic inflammatory reactionHLA-DQ8Intranasal instillationIgE productionInflammatory componentHLA-DQ6Tg miceInflammatory reactionSignificant IgG1Transgenic miceInduced hypersensitivityImmunogenic propertiesSusceptibility markersGenetic susceptibilityImmunodominant regionMiceVivo studiesAllergic propertiesHypersensitivityDetergent enzymes
2004
HLA Class II transgenic mice as models to study the allergenicity of bacterial protease Y217L BPN'
Finn E, Chapoval S, Xue A, Chowdhary V, Marietta E, Gaffey T, Pursifull A, David C. HLA Class II transgenic mice as models to study the allergenicity of bacterial protease Y217L BPN'. Journal Of Allergy And Clinical Immunology 2004, 113: s141. DOI: 10.1016/j.jaci.2003.12.506.Peer-Reviewed Original ResearchRespiratory immune responsesClass II moleculesDQ6 miceDQ8 miceDR3 miceHLA class II transgenic miceTransgenic miceT cell epitope regionsDR4 transgenic miceII transgenic miceHuman class II moleculesSignificant proliferative responseT cell proliferationT cell epitopesAdditional immunizationsIgG1 responseOccupational allergensTg miceAllergic responsesAb productionImmune responseProliferative responseCell epitopesIgEEosinophilia