1994
Inhibition of protein kinase C of human neutrophils by phosphatidylcholines
Yoshida K, Mohsenin V. Inhibition of protein kinase C of human neutrophils by phosphatidylcholines. Life Sciences 1994, 54: 515-524. PMID: 8107528, DOI: 10.1016/0024-3205(94)90001-9.Peer-Reviewed Original ResearchConceptsEffect of phosphatidylcholineProtein kinase CActivation of neutrophilsIntact neutrophilsMechanism of actionPKC activityPulmonary surfactant phospholipidsNeutrophil activationActivation of PKCKinase CNeutrophilsIntact restingTranslocation of PKCHuman neutrophilsSurfactant phospholipidsCytosolic PKC activityDistribution of PKCSuperoxide generationControl cellsPulmonary surfactantSpecific phosphatidylcholinesStimulationActivationFatty acyl moietiesInhibition
1993
Glucose suppresses superoxide generation in normal neutrophils: interference in phospholipase D activation
Ortmeyer J, Mohsenin V. Glucose suppresses superoxide generation in normal neutrophils: interference in phospholipase D activation. American Journal Of Physiology 1993, 264: c402-c410. PMID: 8383432, DOI: 10.1152/ajpcell.1993.264.2.c402.Peer-Reviewed Original ResearchConceptsNormal neutrophilsActivation of PLDNADPH oxidaseTreatment of neutrophilsReceptor-mediated stimulationN-formyl-MetPLD activationDiabetic subjectsFormation of inositolReceptor stimulationPhosphoinositide hydrolysisGlucose suppressesIntracellular Ca2NeutrophilsPhospholipase D activationMarked inhibitionLeu-PhePhospholipase D activityGeneration of O2D activationNonmetabolizable sugarPhosphatidic acidSuperoxide anionActivationGlucose