2023
Loss of CEACAM1 in endothelial cells causes hepatic fibrosis
Muturi H, Ghadieh H, Abdolahipour R, Stankus H, Belew G, Liu J, Jahromi M, Lee A, Singer B, Angeli-Pahim I, Sehrawat T, Malhi H, Verhulst S, van Grunsven L, Zarrinpar A, Duarte S, Najjar S. Loss of CEACAM1 in endothelial cells causes hepatic fibrosis. Metabolism 2023, 144: 155562. PMID: 37088122, PMCID: PMC10330196, DOI: 10.1016/j.metabol.2023.155562.Peer-Reviewed Original ResearchConceptsFl/Hepatic fibrosisEndothelial lossVisceral obesityImmunohistochemical analysisWild-type HSCsEndothelial cellsHepatic fibrosis stageLiver tissue biopsiesHepatic stellate cellsNF-κB signalingLiver endothelial cellsNF-κB targetsLiver transplantAdult patientsBariatric surgerySystemic inflammationInflammatory infiltrationLiver biopsyNASH pathogenesisInsulin resistanceFibrosis stageInsulin sensitivityHepatic fibrogenesisMale mice
2022
THU033 Improving NIAAA criteria for the diagnosis of alcoholic hepatitis, role of systemic inflammation
Pose E, Avitabile E, Díaz A, Montironi C, Perez M, Gratacós-Gines J, Evole H, Sehrawat T, Malhi H, Olivas P, Hernandez-Gea V, Shah V, Kamath P, Ginès P. THU033 Improving NIAAA criteria for the diagnosis of alcoholic hepatitis, role of systemic inflammation. Journal Of Hepatology 2022, 77: s136-s137. DOI: 10.1016/s0168-8278(22)00653-5.Peer-Reviewed Original Research