2018
Primary Liver Tumors Other than Hepatocellular Carcinoma: Clinical and Molecular Pearls
Costantino A, Taddei T. Primary Liver Tumors Other than Hepatocellular Carcinoma: Clinical and Molecular Pearls. Current Hepatology Reports 2018, 17: 412-424. DOI: 10.1007/s11901-018-0426-6.Peer-Reviewed Original ResearchHepatocellular carcinomaRare tumorRare liver tumorGreater survival benefitRare malignant tumorRecent FindingsRecent literatureMetastatic diseaseSurgical resectionSurvival benefitAtypical presentationTherapeutic optionsPrimary liverNovel therapiesDifferential diagnosisMalignant tumorsFibrolamellar HCCLiver tumorsTherapeutic interventionsTumor typesTumor biologyCarcinomaTherapeutic possibilitiesTumorsMolecular pathwaysOngoing studies
2017
Exome analysis of the evolutionary path of hepatocellular adenoma-carcinoma transition, vascular invasion and brain dissemination
Vilarinho S, Erson-Omay E, Mitchell-Richards K, Cha C, Nelson-Williams C, Harmancı AS, Yasuno K, Günel M, Taddei TH. Exome analysis of the evolutionary path of hepatocellular adenoma-carcinoma transition, vascular invasion and brain dissemination. Journal Of Hepatology 2017, 67: 186-191. PMID: 28323122, PMCID: PMC5497691, DOI: 10.1016/j.jhep.2017.03.009.Peer-Reviewed Original ResearchConceptsAdenoma-carcinoma transitionHepatocellular adenomaBrain metastasesHepatocellular carcinomaVascular invasionTumor thrombusCatenin beta 1Rare benign liver tumorMultifocal hepatic lesionsAcute abdominal painBenign liver tumorsPeripheral blood leucocytesSomatic mutationsWhole-exome sequencingParaffin-embedded samplesBrain disseminationAbdominal painLeft hepatectomyMajor complicationsLiver diseaseSpontaneous hemorrhageLeft lobeDisease progressionBlood leucocytesLiver tumors
2016
Protective altruistic phlebotomy: hereditary haemochromatosis presenting as hepatocellular carcinoma in a non-cirrhotic 83-year-old man
Ooka K, Onyiuke I, Zhang X, Taddei TH. Protective altruistic phlebotomy: hereditary haemochromatosis presenting as hepatocellular carcinoma in a non-cirrhotic 83-year-old man. BMJ Case Reports 2016, 2016: bcr2016216649. PMID: 27591041, PMCID: PMC5020720, DOI: 10.1136/bcr-2016-216649.Peer-Reviewed Case Reports and Technical NotesConceptsHepatocellular carcinomaHereditary haemochromatosisSolitary liver tumorSigns of recurrenceAbdominal painElevated transaminasesHepatic manifestationLiver diseaseLate presentationSurveillance imagingIron overloadRoutine phlebotomyLiver tumorsMultisystem disorderCarcinomaHaemochromatosisNew complicationsCirrhosisPartial hepatectomyIron metabolismMenHepatomegalyPainComplicationsHaemosiderosis
2013
Notching up on the cellular origins of intrahepatic cholangiocarcinoma
Sirica A, Groszmann R, Iwakiri Y, Taddei T. Notching up on the cellular origins of intrahepatic cholangiocarcinoma. Hepatology 2013, 57: 1668-1671. PMID: 23390051, DOI: 10.1002/hep.26313.Peer-Reviewed Original ResearchOrigin of intrahepatic cholangiocarcinomaBiliary lineage cellsLiver progenitor cellsBiliary epithelial cellsIntrahepatic cholangiocarcinomaCell type-specific reportersMouse modelLineage cellsCellular originMouse model of intrahepatic cholangiocarcinomaPrimary liver tumorsActivated NotchDevelopment of effective therapiesNotch activationAkt signalingLiver cell typesCell typesRefractory diseasePrimary malignancyPoor prognosisViral hepatitisLiver tumorsMalignant tumorsEffective therapyProgenitor cells