Featured Publications
The Addiction Recovery Clinic
Holt SR, Segar N, Cavallo DA, Tetrault JM. The Addiction Recovery Clinic. Academic Medicine 2017, 92: 680-683. PMID: 28441678, DOI: 10.1097/acm.0000000000001480.Peer-Reviewed Original ResearchConceptsPatient satisfaction surveyInternal medicine residentsRecovery clinicSubstance useMedicine residentsUse disordersAddiction medicine specialistsOpioid use disorderOutpatient clinical servicesPrimary care practicesUnhealthy substance useSubstance use disordersAddiction treatment facilitiesSatisfaction surveyDirect referralNew patientsMedicine specialistsPatientsCare practicesPatient encountersConsecutive weeksBehavioral treatmentAddiction medicineClinical servicesVisit number
2020
Computerized Cognitive Behavioral Therapy for Substance Use Disorders in a Specialized Primary Care Practice: A Randomized Feasibility Trial to Address the RT Component of SBIRT.
Tetrault JM, Holt SR, Cavallo DA, O'Connor PG, Gordon MA, Corvino JK, Nich C, Carroll KM. Computerized Cognitive Behavioral Therapy for Substance Use Disorders in a Specialized Primary Care Practice: A Randomized Feasibility Trial to Address the RT Component of SBIRT. Journal Of Addiction Medicine 2020, 14: e303-e309. PMID: 32371660, DOI: 10.1097/adm.0000000000000663.Peer-Reviewed Original ResearchConceptsSubstance use disordersComputerized cognitive behavioral therapySubstance useCognitive behavioral therapySelf-reported substance useUse disordersTechnology-based treatmentsPrimary care settingSubstance use outcomesIntegrated addictions treatmentTechnology-based interventionsBehavioral therapyPrimary care practicesOverall positive outcomeSUD interventionsBrief interventionUnhealthy alcohol useDays abstinentPositive outcomesUse outcomesCare settingsAlcohol useStandard careAddiction treatmentTreatment settings
2019
A scalable, automated warm handoff from the emergency department to community sites offering continued medication for opioid use disorder: Lessons learned from the EMBED trial stakeholders
Ahmed OM, Mao JA, Holt SR, Hawk K, D'Onofrio G, Martel S, Melnick ER. A scalable, automated warm handoff from the emergency department to community sites offering continued medication for opioid use disorder: Lessons learned from the EMBED trial stakeholders. Journal Of Substance Use And Addiction Treatment 2019, 102: 47-52. PMID: 31202288, PMCID: PMC6578846, DOI: 10.1016/j.jsat.2019.05.006.Peer-Reviewed Original ResearchConceptsOpioid use disorderUse disordersCommunity providersCommunity sitesEmergency department-initiated buprenorphineTreatment referral programNeeds assessmentStakeholder meetingsKey stakeholder meetingsED referralsED cliniciansEmergency departmentWarm handoffsMOUDReferral systemReferral processSite referralTrials NetworkPatient identifiersReferral programReferralMedicationsPatientsHIPAA-compliant mannerDisordersUnhealthy Alcohol Use
Holt S, Donroe J. Unhealthy Alcohol Use. DeckerMed Psychiatry 2019 DOI: 10.2310/psych.13106.Peer-Reviewed Original Research
2018
Pharmacotherapy for Alcohol Use Disorder
Holt SR, Tobin DG. Pharmacotherapy for Alcohol Use Disorder. Medical Clinics Of North America 2018, 102: 653-666. PMID: 29933821, DOI: 10.1016/j.mcna.2018.02.008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAlcohol use disorderUse disordersNondrug therapiesUndertreated diseaseTreatment optionsPharmacotherapeutic agentsDrug interactionsTreatment goalsUS FoodDrug AdministrationSpecific patientDrug availabilityDisordersPatientsCounseling strategiesComorbiditiesMedicationsPharmacotherapyOptionsTherapyDiseaseAdministrationCareAddressing discordant quantitative urine buprenorphine and norbuprenorphine levels: Case examples in opioid use disorder
Holt SR, Donroe JH, Cavallo DA, Tetrault JM. Addressing discordant quantitative urine buprenorphine and norbuprenorphine levels: Case examples in opioid use disorder. Drug And Alcohol Dependence 2018, 186: 171-174. PMID: 29579725, DOI: 10.1016/j.drugalcdep.2017.12.040.Peer-Reviewed Original ResearchConceptsOngoing illicit drug usePatient-provider relationshipOpioid use disorderIllicit drug useUse disordersUrine adulterationTreatment planDrug useQuantitative urine testingMethadone treatment programsSubstance use disordersNorbuprenorphine levelsUrine buprenorphineUrine testingPatientsTreatment programNonjudgmental approachUrine samplesTherapeutic allianceDiscordant levelsBuprenorphineDisordersUrineNorbuprenorphineLevels
2017
Interpreting quantitative urine buprenorphine and norbuprenorphine levels in office-based clinical practice
Donroe JH, Holt SR, O’Connor P, Sukumar N, Tetrault JM. Interpreting quantitative urine buprenorphine and norbuprenorphine levels in office-based clinical practice. Drug And Alcohol Dependence 2017, 180: 46-51. PMID: 28866369, DOI: 10.1016/j.drugalcdep.2017.07.040.Peer-Reviewed Original ResearchConceptsOpioid use disorderUrine buprenorphineNorbuprenorphine levelsUrine adulterationAddiction treatment clinicsTreatment clinicsBuprenorphine medicationSublingual buprenorphineBuprenorphine treatmentTreatment cohortsRetrospective studyUrine specimenBuprenorphineUse disordersPatientsClinical practiceUrine samplesUrineClinicTreatmentMedicationsLevelsNorBUPCohortSuspicion
2016
Caring for patients with opioid use disorder in the hospitalCaring for patients with opioid use disorder in the hospital
Donroe JH, Holt SR, Tetrault JM. Caring for patients with opioid use disorder in the hospitalCaring for patients with opioid use disorder in the hospital. Canadian Medical Association Journal 2016, 188: cmaj.160290. PMID: 27647616, PMCID: PMC5135493, DOI: 10.1503/cmaj.160290.Peer-Reviewed Original ResearchUnhealthy Alcohol Use
Holt S, Tetrault J. Unhealthy Alcohol Use. Clinics In Liver Disease 2016, 20: 429-444. PMID: 27373607, DOI: 10.1016/j.cld.2016.02.003.Peer-Reviewed Original ResearchConceptsUnhealthy alcohol useAlcohol useSymptom-triggered approachAlcohol use disorderAlcohol withdrawalAppropriate treatmentRoutine screeningPatient motivationUse disordersBrief interventionHazardous drinkingBehavioral therapyHeavy drinkingPatientsRobust dataBehavioral changesDrinkingTwelve-step programsMedicationsTherapyBenzodiazepinesAbstinence