2012
Clinical regressions and broad immune activation following combination therapy targeting human NKT cells in myeloma
Richter J, Neparidze N, Zhang L, Nair S, Monesmith T, Sundaram R, Miesowicz F, Dhodapkar KM, Dhodapkar MV. Clinical regressions and broad immune activation following combination therapy targeting human NKT cells in myeloma. Blood 2012, 121: 423-430. PMID: 23100308, PMCID: PMC3548165, DOI: 10.1182/blood-2012-06-435503.Peer-Reviewed Original ResearchConceptsHuman iNKT cellsINKT cellsCombination therapyAntitumor T-cell immunitySerum soluble IL2 receptorMonocyte-derived dendritic cellsNatural killer T cellsBroad immune activationLow-dose lenalidomideSoluble IL2 receptorCycles of therapyHuman NKT cellsT cell immunityKiller T cellsInnate immune cellsInduction of eosinophiliaActivation of monocytesPrevention of cancerCycles of combinationAsymptomatic myelomaClinical myelomaMeasurable diseaseClinical regressionClinical responseNKT cells
2009
The PPE18 of Mycobacterium tuberculosis Interacts with TLR2 and Activates IL-10 Induction in Macrophage
Nair S, Ramaswamy PA, Ghosh S, Joshi DC, Pathak N, Siddiqui I, Sharma P, Hasnain SE, Mande SC, Mukhopadhyay S. The PPE18 of Mycobacterium tuberculosis Interacts with TLR2 and Activates IL-10 Induction in Macrophage. The Journal Of Immunology 2009, 183: 6269-6281. PMID: 19880448, DOI: 10.4049/jimmunol.0901367.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, BacterialBacterial ProteinsCell LineCytokinesExtracellular Signal-Regulated MAP KinasesHumansInterleukin-10LipopolysaccharidesMacrophage ActivationMacrophagesMAP Kinase Kinase 4MonocytesMycobacterium tuberculosisP38 Mitogen-Activated Protein KinasesRecombinant ProteinsSignal TransductionToll-Like Receptor 2TuberculosisConceptsIL-10 inductionIL-10Proline-glutamic acidTh2-type responseIL-10 productionAnti-inflammatory responseMycobacterium tuberculosis strainsTHP-1 macrophagesPPE18 proteinInfected macrophagesTuberculosis strainsTLR2PPE18Synthetic lipopeptideMycobacterium tuberculosisMacrophagesMycobacterium tuberculosis interactsERK 1/2M. smegmatis strainPathophysiological functionsP38 MAPKType responseSilico docking analysisSustained activationPoor level