2012
Pathogenesis in tuberculosis: transcriptomic approaches to unraveling virulence mechanisms and finding new drug targets
Mukhopadhyay S, Nair S, Ghosh S. Pathogenesis in tuberculosis: transcriptomic approaches to unraveling virulence mechanisms and finding new drug targets. FEMS Microbiology Reviews 2012, 36: 463-485. PMID: 22092372, DOI: 10.1111/j.1574-6976.2011.00302.x.Peer-Reviewed Original ResearchConceptsMajor health problemHost immune responseEmergence of strainsDrug targetsDendritic cellsEffective drug targetsInhibition of apoptosisImmune responseNew drug targetsHealth problemsLipid metabolismMultiple drugsTuberculosisComplex etiologyMycobacterium tuberculosisIntracellular life styleTranscriptome signaturesVirulence mechanismsGenome-wide expression profilingDrugsAntibiotic drugsExpression profilingProtein secretionLife stylePoor understanding
2009
The PPE18 of Mycobacterium tuberculosis Interacts with TLR2 and Activates IL-10 Induction in Macrophage
Nair S, Ramaswamy PA, Ghosh S, Joshi DC, Pathak N, Siddiqui I, Sharma P, Hasnain SE, Mande SC, Mukhopadhyay S. The PPE18 of Mycobacterium tuberculosis Interacts with TLR2 and Activates IL-10 Induction in Macrophage. The Journal Of Immunology 2009, 183: 6269-6281. PMID: 19880448, DOI: 10.4049/jimmunol.0901367.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, BacterialBacterial ProteinsCell LineCytokinesExtracellular Signal-Regulated MAP KinasesHumansInterleukin-10LipopolysaccharidesMacrophage ActivationMacrophagesMAP Kinase Kinase 4MonocytesMycobacterium tuberculosisP38 Mitogen-Activated Protein KinasesRecombinant ProteinsSignal TransductionToll-Like Receptor 2TuberculosisConceptsIL-10 inductionIL-10Proline-glutamic acidTh2-type responseIL-10 productionAnti-inflammatory responseMycobacterium tuberculosis strainsTHP-1 macrophagesPPE18 proteinInfected macrophagesTuberculosis strainsTLR2PPE18Synthetic lipopeptideMycobacterium tuberculosisMacrophagesMycobacterium tuberculosis interactsERK 1/2M. smegmatis strainPathophysiological functionsP38 MAPKType responseSilico docking analysisSustained activationPoor level
2008
The PPE Protein Rv1196 of Mycobacterium tuberculosis Exploits the TLR2 Signaling in Macrophages Eliciting an Anti-Inflammatory Response by Producing IL-10
Mukhopadhyay S, Nair S, Mande S, Hasnain S. The PPE Protein Rv1196 of Mycobacterium tuberculosis Exploits the TLR2 Signaling in Macrophages Eliciting an Anti-Inflammatory Response by Producing IL-10. International Journal Of Infectious Diseases 2008, 12: e477. DOI: 10.1016/j.ijid.2008.05.1351.Peer-Reviewed Original Research