Glutathione-Redox Balance Regulates c-rel–Driven IL-12 Production in Macrophages: Possible Implications in Antituberculosis Immunotherapy
Alam K, Ghousunnissa S, Nair S, Valluri VL, Mukhopadhyay S. Glutathione-Redox Balance Regulates c-rel–Driven IL-12 Production in Macrophages: Possible Implications in Antituberculosis Immunotherapy. The Journal Of Immunology 2010, 184: 2918-2929. PMID: 20164428, DOI: 10.4049/jimmunol.0900439.Peer-Reviewed Original ResearchConceptsIL-12 productionImmune responseGlutathione redox balanceEnhanced Th1 responseProtective Th1 typeTNF-alpha levelsCellular immune responsesIFN-gamma productionIL-12 inductionBacillus Calmette-GuérinIL-12 cytokinesActive tuberculosisTh1 responseTh1 typeGlutathione ethyl esterNAC treatmentP70 productionCalmette-GuérinIntracellular reduced glutathioneP65 NF-kappaB.Pathophysiological disordersNF-kappaB.IkappaBalpha phosphorylationGSH donorMacrophages