2015
Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin
KIM K, KIM S, YU S, PARK S, CHOI H, YU H, JI J, SEO Y, AHN S. Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin. Molecular Medicine Reports 2015, 12: 1898-1904. PMID: 25892525, PMCID: PMC4464330, DOI: 10.3892/mmr.2015.3633.Peer-Reviewed Original ResearchConceptsEfflux of doxorubicinMCF-7/MDR cellsHuman breast cancer cellsBreast cancer cellsMultidrug resistanceMDR cellsCancer cellsReverses multidrug resistanceDose-dependent mannerMDR cancer therapyResistance of doxorubicinHuman multidrug resistanceNet cellular uptakeMDR-1Chemotherapeutic agentsMRP-1Cytometric analysisProtein levelsCancer therapyDoxorubicinExpression levelsAnticancer propertiesSalinomycinPresent studyEfflux
2011
Silibinin Inhibits Cell Growth and Induces Apoptosis through Cell-cycle Arrest in PC-3 Prostate Cancer Cells
Kim S, Kim K, Yu S, Jeon H, Jin Y, Lee C, Ahn S. Silibinin Inhibits Cell Growth and Induces Apoptosis through Cell-cycle Arrest in PC-3 Prostate Cancer Cells. Journal Of Life Science 2011, 21: 1573-1578. DOI: 10.5352/jls.2011.21.11.1573.Peer-Reviewed Original ResearchCell cycle check point proteinsCell cycle arrestDose-dependent mannerCheck point proteinsPC-3Cycle arrestProstate cancer cell line PC-3Cancer cell line PC-3Cyclin-dependent kinases 2/4/6PC-3 prostate cancer cellsCell line PC-3Milk thistleProstate cancer cells PC-3Prostate cancer cellsPC-3 cellsPI double stainingCancer cell linesCell growthInhibits cell growthChemopreventive effectsPoly (ADP-ribose) polymerase cleavageAnticancer effectsFlow cytometryRadical scavenger activityCaspase-3 activation