2018
Epidermal growth factor receptor peptide vaccination induces cross-reactive immunity to human EGFR, HER2, and HER3
Doyle HA, Koski RA, Bonafé N, Bruck RA, Tagliatela SM, Gee RJ, Mamula MJ. Epidermal growth factor receptor peptide vaccination induces cross-reactive immunity to human EGFR, HER2, and HER3. Cancer Immunology, Immunotherapy 2018, 67: 1559-1569. PMID: 30056598, PMCID: PMC7268894, DOI: 10.1007/s00262-018-2218-9.Peer-Reviewed Original ResearchConceptsAntibody-dependent cell-mediated cytotoxicityEpidermal growth factor receptorAnti-tumor immunityMonoclonal antibody treatmentAntibody treatmentImmune serumElicit anti-tumor immunityAnti-EGFR monoclonal antibodiesHuman epidermal growth factor receptorPeptide-based vaccinationCross-reactive immunityT cell responsesCell-mediated cytotoxicityAnti-tumor antibodiesNatural anti-tumor antibodiesMDA-MB-453Tumor cell killingErbB family membersGrowth factor receptorPeptide vaccinationStandard chemotherapyImmune toleranceCurrent treatmentDrug infusionRadiation therapy
2006
Isoaspartyl Post-translational Modification Triggers Anti-tumor T and B Lymphocyte Immunity*
Doyle HA, Zhou J, Wolff MJ, Harvey BP, Roman RM, Gee RJ, Koski RA, Mamula MJ. Isoaspartyl Post-translational Modification Triggers Anti-tumor T and B Lymphocyte Immunity*. Journal Of Biological Chemistry 2006, 281: 32676-32683. PMID: 16950786, DOI: 10.1074/jbc.m604847200.Peer-Reviewed Original ResearchConceptsTRP-2 peptideImmune toleranceT cellsNormal immune tolerancePeptide-pulsed targetsPeptide-immunized miceCytotoxic T lymphocytesB cell toleranceStrong immune responseTetramer analysisLymphocyte immunityMelanoma antigensT lymphocytesImmune responseCell toleranceImmune systemPost-translational protein modificationTyrosinase-related proteinCD8AntigenTumor proteinCellsImmunizationLymphocytesMice
2003
A Failure to Repair Self-Proteins Leads to T Cell Hyperproliferation and Autoantibody Production
Doyle HA, Gee RJ, Mamula MJ. A Failure to Repair Self-Proteins Leads to T Cell Hyperproliferation and Autoantibody Production. The Journal Of Immunology 2003, 171: 2840-2847. PMID: 12960305, DOI: 10.4049/jimmunol.171.6.2840.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantibodiesAutoantigensBone Marrow TransplantationCD28 AntigensCell DivisionImmunophenotypingIsoaspartic AcidLupus Erythematosus, SystemicLymph NodesLymphocyte ActivationLymphoid TissueMiceMice, Inbred C57BLMice, KnockoutMitogensPhosphorylationProtein D-Aspartate-L-Isoaspartate MethyltransferaseReceptors, Antigen, T-CellSignal TransductionT-LymphocytesConceptsProtein carboxyl methyltransferasePhosphorylation of membersSpontaneous posttranslational modificationAg receptor stimulationCarboxyl methyltransferasePosttranslational modificationsBiological functionsT cell hyperproliferationCell homeostasisCell stressImmune toleranceT cellsT cell homeostasisSystemic lupus erythematosusPeripheral immune toleranceWild-type miceCell hyperproliferationAnti-DNA autoantibodiesHomeostasisLupus erythematosusAutoantibody productionAutoimmune pathologyKidney pathologyT lymphocytesEffector functions
1999
B7 costimulation in the development of lupus: autoimmunity arises either in the absence of B7.1/B7.2 or in the presence of anti-b7.1/B7.2 blocking antibodies.
Liang B, Gee RJ, Kashgarian MJ, Sharpe AH, Mamula MJ. B7 costimulation in the development of lupus: autoimmunity arises either in the absence of B7.1/B7.2 or in the presence of anti-b7.1/B7.2 blocking antibodies. The Journal Of Immunology 1999, 163: 2322-9. PMID: 10438978, DOI: 10.4049/jimmunol.163.4.2322.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearAntibodies, BlockingAntibodies, MonoclonalAntigens, CDAutoantibodiesB7-1 AntigenB7-2 AntigenDNAGlomerulonephritisKidneyLupus Erythematosus, SystemicLymphocyte ActivationMembrane GlycoproteinsMiceMice, Inbred BALB CMice, Inbred C57BLMice, Inbred MRL lprMice, KnockoutRibonucleoproteins, Small NuclearConceptsMRL-lpr/lpr miceAnti-dsDNA autoantibodiesSystemic lupus erythematosusLpr miceAutoantibody expressionLupus erythematosusB7 costimulationAb treatmentMRL-lpr/lpr murine modelAnti-small nuclear ribonucleoproteinAge-matched wild-type miceHuman systemic lupus erythematosusMurine systemic lupus erythematosusDevelopment of lupusB7 costimulatory signalsWild-type miceB7.1/B7.2Autoantibody titersSevere glomerulonephritisSurface of APCsAutoantibody profileUntreated miceCostimulatory moleculesKidney pathologyT lymphocytesT cell autoimmunity in Ig transgenic mice.
Shinde S, Gee R, Santulli-Marotto S, Bockenstedt L, Clarke S, Mamula M. T cell autoimmunity in Ig transgenic mice. The Journal Of Immunology 1999, 162: 7519-24. PMID: 10358207, DOI: 10.4049/jimmunol.162.12.7519.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationAutoantigensB-LymphocytesCD4-Positive T-LymphocytesFlow CytometryGenes, ImmunoglobulinHistocompatibility Antigens Class IILupus Erythematosus, SystemicMiceMice, Inbred C57BLMice, Inbred MRL lprMice, TransgenicPeptidesReceptors, Antigen, B-CellRibonucleoproteins, Small NuclearT-LymphocytesConceptsAutoreactive T cellsCD4 T cellsT cellsTransgenic miceB lymphocytesMRL-lpr/lpr miceLpr/lpr miceT cell autoimmunityAutoreactive B lymphocytesSystemic lupus erythematosusWild-type C57BL/6Wild-type miceC57BL/6 transgenic miceTransgenic B lymphocytesIg transgenic miceB cell APCCell autoimmunityLupus erythematosusLpr miceT lymphocytesMurine modelImmature phenotypeLymphocytesVivo activationMice