2013
Autoantigens: Novel forms and presentation to the immune system
Doyle HA, Yang ML, Raycroft MT, Gee RJ, Mamula MJ. Autoantigens: Novel forms and presentation to the immune system. Autoimmunity 2013, 47: 220-233. PMID: 24191689, DOI: 10.3109/08916934.2013.850495.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationAutoantigensAutoimmune DiseasesAutoimmunityHumansImmune SystemProtein Processing, Post-TranslationalConceptsLupus autoimmunityPresence of autoantibodiesChronic autoimmune diseaseVariety of abnormalitiesAutoantigen presentationAutoimmune diseasesClinical expressionRelated syndromesImmune systemTissue pathologyAutoimmunityNon-genetic factorsAltered pathwaysMicroenvironmental influencesDiseasePresentationCell surfaceAutoantibodiesLupusSyndromeAbnormalities
2007
Antigen presentation and transfer between B cells and macrophages
Harvey BP, Gee RJ, Haberman AM, Shlomchik MJ, Mamula MJ. Antigen presentation and transfer between B cells and macrophages. European Journal Of Immunology 2007, 37: 1739-1751. PMID: 17534863, DOI: 10.1002/eji.200636452.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsB cell receptorCD4 T cellsB cellsT cellsImmune responseOngoing immune responseTransfer of antigenDendritic cellsAntigen transferAntigen presentationMHC compatibilitySelf proteinsSpecific antigenCell receptorAntigenMacrophagesActivation stateImmunityNovel mechanismCellsPrior findingsReceptorsResponse
2006
B Cells Drive Early T Cell Autoimmunity In Vivo prior to Dendritic Cell-Mediated Autoantigen Presentation
Yan J, Harvey BP, Gee RJ, Shlomchik MJ, Mamula MJ. B Cells Drive Early T Cell Autoimmunity In Vivo prior to Dendritic Cell-Mediated Autoantigen Presentation. The Journal Of Immunology 2006, 177: 4481-4487. PMID: 16982884, DOI: 10.4049/jimmunol.177.7.4481.Peer-Reviewed Original ResearchConceptsAutoreactive T cellsDendritic cellsT cellsB cellsAutoantigen-specific B cellsAutoimmune T cell responsesSelf-reactive T cellsAutoantigen-presenting cellsExposure of autoantigensT cell autoimmunityT cell responsesTransgenic mouse modelAutoantigen presentationCell autoimmunityIg transgenic mouse modelProfessional APCsSelf-AgMouse modelEffective APCsCell responsesVivo studiesAutoimmunityLupusAPCCells
1999
T cell autoimmunity in Ig transgenic mice.
Shinde S, Gee R, Santulli-Marotto S, Bockenstedt L, Clarke S, Mamula M. T cell autoimmunity in Ig transgenic mice. The Journal Of Immunology 1999, 162: 7519-24. PMID: 10358207, DOI: 10.4049/jimmunol.162.12.7519.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationAutoantigensB-LymphocytesCD4-Positive T-LymphocytesFlow CytometryGenes, ImmunoglobulinHistocompatibility Antigens Class IILupus Erythematosus, SystemicMiceMice, Inbred C57BLMice, Inbred MRL lprMice, TransgenicPeptidesReceptors, Antigen, B-CellRibonucleoproteins, Small NuclearT-LymphocytesConceptsAutoreactive T cellsCD4 T cellsT cellsTransgenic miceB lymphocytesMRL-lpr/lpr miceLpr/lpr miceT cell autoimmunityAutoreactive B lymphocytesSystemic lupus erythematosusWild-type C57BL/6Wild-type miceC57BL/6 transgenic miceTransgenic B lymphocytesIg transgenic miceB cell APCCell autoimmunityLupus erythematosusLpr miceT lymphocytesMurine modelImmature phenotypeLymphocytesVivo activationMice