2006
B Cells Drive Early T Cell Autoimmunity In Vivo prior to Dendritic Cell-Mediated Autoantigen Presentation
Yan J, Harvey BP, Gee RJ, Shlomchik MJ, Mamula MJ. B Cells Drive Early T Cell Autoimmunity In Vivo prior to Dendritic Cell-Mediated Autoantigen Presentation. The Journal Of Immunology 2006, 177: 4481-4487. PMID: 16982884, DOI: 10.4049/jimmunol.177.7.4481.Peer-Reviewed Original ResearchConceptsAutoreactive T cellsDendritic cellsT cellsB cellsAutoantigen-specific B cellsAutoimmune T cell responsesSelf-reactive T cellsAutoantigen-presenting cellsExposure of autoantigensT cell autoimmunityT cell responsesTransgenic mouse modelAutoantigen presentationCell autoimmunityIg transgenic mouse modelProfessional APCsSelf-AgMouse modelEffective APCsCell responsesVivo studiesAutoimmunityLupusAPCCells
1999
B7 costimulation in the development of lupus: autoimmunity arises either in the absence of B7.1/B7.2 or in the presence of anti-b7.1/B7.2 blocking antibodies.
Liang B, Gee RJ, Kashgarian MJ, Sharpe AH, Mamula MJ. B7 costimulation in the development of lupus: autoimmunity arises either in the absence of B7.1/B7.2 or in the presence of anti-b7.1/B7.2 blocking antibodies. The Journal Of Immunology 1999, 163: 2322-9. PMID: 10438978, DOI: 10.4049/jimmunol.163.4.2322.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearAntibodies, BlockingAntibodies, MonoclonalAntigens, CDAutoantibodiesB7-1 AntigenB7-2 AntigenDNAGlomerulonephritisKidneyLupus Erythematosus, SystemicLymphocyte ActivationMembrane GlycoproteinsMiceMice, Inbred BALB CMice, Inbred C57BLMice, Inbred MRL lprMice, KnockoutRibonucleoproteins, Small NuclearConceptsMRL-lpr/lpr miceAnti-dsDNA autoantibodiesSystemic lupus erythematosusLpr miceAutoantibody expressionLupus erythematosusB7 costimulationAb treatmentMRL-lpr/lpr murine modelAnti-small nuclear ribonucleoproteinAge-matched wild-type miceHuman systemic lupus erythematosusMurine systemic lupus erythematosusDevelopment of lupusB7 costimulatory signalsWild-type miceB7.1/B7.2Autoantibody titersSevere glomerulonephritisSurface of APCsAutoantibody profileUntreated miceCostimulatory moleculesKidney pathologyT lymphocytesIsoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins*
Mamula M, Gee R, Elliott J, Sette A, Southwood S, Jones P, Blier P. Isoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins*. Journal Of Biological Chemistry 1999, 274: 22321-22327. PMID: 10428801, DOI: 10.1074/jbc.274.32.22321.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAspartic AcidAutoantibodiesAutoimmunityBinding, CompetitiveB-LymphocytesCytochrome c GroupHistocompatibility Antigens Class IIImmune ToleranceIsomerismLymphocyte ActivationMiceMice, Inbred MRL lprMolecular Sequence DataNuclear Magnetic Resonance, BiomolecularPeptide FragmentsProtein BindingProtein Processing, Post-TranslationalRibonucleoproteins, Small NuclearT-LymphocytesConceptsSystemic lupus erythematosusAutoimmune responseT cell autoimmune responsesHuman systemic lupus erythematosusInitiation of autoimmunityT cell compartmentT cell responsesImmunization of miceFunctioning immune systemLupus erythematosusSelf antigensAutoimmune diseasesImmunologic stimuliC-peptidePeptide autoantigensImmune systemCell responsesForeign pathogensImmunizationCytochrome c peptideMiceCell compartmentPresent studyPeptidesResponseT cell autoimmunity in Ig transgenic mice.
Shinde S, Gee R, Santulli-Marotto S, Bockenstedt L, Clarke S, Mamula M. T cell autoimmunity in Ig transgenic mice. The Journal Of Immunology 1999, 162: 7519-24. PMID: 10358207, DOI: 10.4049/jimmunol.162.12.7519.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationAutoantigensB-LymphocytesCD4-Positive T-LymphocytesFlow CytometryGenes, ImmunoglobulinHistocompatibility Antigens Class IILupus Erythematosus, SystemicMiceMice, Inbred C57BLMice, Inbred MRL lprMice, TransgenicPeptidesReceptors, Antigen, B-CellRibonucleoproteins, Small NuclearT-LymphocytesConceptsAutoreactive T cellsCD4 T cellsT cellsTransgenic miceB lymphocytesMRL-lpr/lpr miceLpr/lpr miceT cell autoimmunityAutoreactive B lymphocytesSystemic lupus erythematosusWild-type C57BL/6Wild-type miceC57BL/6 transgenic miceTransgenic B lymphocytesIg transgenic miceB cell APCCell autoimmunityLupus erythematosusLpr miceT lymphocytesMurine modelImmature phenotypeLymphocytesVivo activationMice
1995
Self-peptides in the initiation of lupus autoimmunity.
Bockenstedt LK, Gee RJ, Mamula MJ. Self-peptides in the initiation of lupus autoimmunity. The Journal Of Immunology 1995, 154: 3516-24. PMID: 7534800, DOI: 10.4049/jimmunol.154.7.3516.Peer-Reviewed Original ResearchConceptsSm small nuclear ribonucleoproteinsT cellsAutoreactive T cell proliferationDiverse autoimmune responseSystemic lupus erythematosusT cell responsesTypes of autoimmunityT cell proliferationD proteinsLupus autoimmunityLupus erythematosusLupus autoantigensAutoimmune responseAb responsesNormal miceForeign AgsSmall nuclear ribonucleoproteinImmune systemCell responsesHigh titersImmunofluorescence patternMolecular mimicsAmino acids 26Mouse lymphocytes