2013
Autoantigens: Novel forms and presentation to the immune system
Doyle HA, Yang ML, Raycroft MT, Gee RJ, Mamula MJ. Autoantigens: Novel forms and presentation to the immune system. Autoimmunity 2013, 47: 220-233. PMID: 24191689, DOI: 10.3109/08916934.2013.850495.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationAutoantigensAutoimmune DiseasesAutoimmunityHumansImmune SystemProtein Processing, Post-TranslationalConceptsLupus autoimmunityPresence of autoantibodiesChronic autoimmune diseaseVariety of abnormalitiesAutoantigen presentationAutoimmune diseasesClinical expressionRelated syndromesImmune systemTissue pathologyAutoimmunityNon-genetic factorsAltered pathwaysMicroenvironmental influencesDiseasePresentationCell surfaceAutoantibodiesLupusSyndromeAbnormalities
2007
Altered immunogenicity of isoaspartate containing proteins
Doyle HA, Gee RJ, Mamula MJ. Altered immunogenicity of isoaspartate containing proteins. Autoimmunity 2007, 40: 131-137. PMID: 17453712, DOI: 10.1080/08916930601165180.Peer-Reviewed Original ResearchConceptsPost-translational modificationsIsoaspartyl residuesSuch post-translational modificationsContaining ProteinBiological processesLymphocyte developmentIsoaspartic acidCytochrome cProteinAspartic acidCathepsin DCathepsin digestionPigeon cytochrome cResiduesAntigen processingAltered immunogenicityCellsImmune systemNatural modificationBone marrowToleranceD. AdditionallyEnzymeSpontaneous conversionAcid
2006
Intracellular Protein Modification Associated with Altered T Cell Functions in Autoimmunity
Yang ML, Doyle HA, Gee RJ, Lowenson JD, Clarke S, Lawson BR, Aswad DW, Mamula MJ. Intracellular Protein Modification Associated with Altered T Cell Functions in Autoimmunity. The Journal Of Immunology 2006, 177: 4541-4549. PMID: 16982891, DOI: 10.4049/jimmunol.177.7.4541.Peer-Reviewed Original ResearchConceptsAutoimmune miceNZB/W miceAltered T cell functionT-cell proliferative defectsNZB/WMRL/lprT cell functionStrains of miceImmunologic responseW miceAntigenic stimulationT cellsT lymphocytesMRL miceMiceCell functionIntracellular levelsProliferative defectPhysiologic pHAgeNonenzymatic modificationAutoimmunityLymphocytesProtein processingKidneyIsoaspartyl Post-translational Modification Triggers Anti-tumor T and B Lymphocyte Immunity*
Doyle HA, Zhou J, Wolff MJ, Harvey BP, Roman RM, Gee RJ, Koski RA, Mamula MJ. Isoaspartyl Post-translational Modification Triggers Anti-tumor T and B Lymphocyte Immunity*. Journal Of Biological Chemistry 2006, 281: 32676-32683. PMID: 16950786, DOI: 10.1074/jbc.m604847200.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, NeoplasmB-LymphocytesCD8-Positive T-LymphocytesCell Line, TumorIn Vitro TechniquesIsoaspartic AcidMelanoma, ExperimentalMiceMice, Inbred C57BLMolecular StructureProtein Processing, Post-TranslationalT-LymphocytesVaccinationConceptsTRP-2 peptideImmune toleranceT cellsNormal immune tolerancePeptide-pulsed targetsPeptide-immunized miceCytotoxic T lymphocytesB cell toleranceStrong immune responseTetramer analysisLymphocyte immunityMelanoma antigensT lymphocytesImmune responseCell toleranceImmune systemPost-translational protein modificationTyrosinase-related proteinCD8AntigenTumor proteinCellsImmunizationLymphocytesMice
1999
Isoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins*
Mamula M, Gee R, Elliott J, Sette A, Southwood S, Jones P, Blier P. Isoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins*. Journal Of Biological Chemistry 1999, 274: 22321-22327. PMID: 10428801, DOI: 10.1074/jbc.274.32.22321.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAspartic AcidAutoantibodiesAutoimmunityBinding, CompetitiveB-LymphocytesCytochrome c GroupHistocompatibility Antigens Class IIImmune ToleranceIsomerismLymphocyte ActivationMiceMice, Inbred MRL lprMolecular Sequence DataNuclear Magnetic Resonance, BiomolecularPeptide FragmentsProtein BindingProtein Processing, Post-TranslationalRibonucleoproteins, Small NuclearT-LymphocytesConceptsSystemic lupus erythematosusAutoimmune responseT cell autoimmune responsesHuman systemic lupus erythematosusInitiation of autoimmunityT cell compartmentT cell responsesImmunization of miceFunctioning immune systemLupus erythematosusSelf antigensAutoimmune diseasesImmunologic stimuliC-peptidePeptide autoantigensImmune systemCell responsesForeign pathogensImmunizationCytochrome c peptideMiceCell compartmentPresent studyPeptidesResponse