Acute physical exercise increases APPL1/PI3K signaling in the hypothalamus of lean mice
Gaspar R, Muñoz V, Kuga G, Nakandakari S, Crisol B, Lenhare L, Breda L, Botezelli J, Sant'Ana M, da Silva A, Cintra D, de Moura L, Ropelle E, Pauli J. Acute physical exercise increases APPL1/PI3K signaling in the hypothalamus of lean mice. European Journal Of Neuroscience 2019, 50: 3181-3190. PMID: 31206806, DOI: 10.1111/ejn.14490.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsEatingHypothalamusMaleMicePhosphatidylinositol 3-KinasePhysical Conditioning, AnimalRNA, MessengerSignal TransductionConceptsLean miceExercise sessionsPhysical exerciseAcute exercise sessionAcute physical exercisePhysical exercise sessionPI3K p110PI3K mRNAAdiponectin pathwayArcuate nucleusSwiss miceHypothalamusAdiponectinEnergy homeostasisMiceMRNA levelsPI3KFood consumptionLeucine zipper motif 1BXD miceExerciseK mRNAPresent studyPositive correlationKey proteins