2018
The reversal effect of physical exercise on aging-related increases in APPL2 content in skeletal muscle
Canciglieri P, Kuga G, Muñoz V, Gaspar R, da Rocha A, Breda L, Anaruma C, Minuzzi L, da Silva A, Cintra D, de Moura L, Ropelle E, Pauli J. The reversal effect of physical exercise on aging-related increases in APPL2 content in skeletal muscle. Life Sciences 2018, 210: 209-213. PMID: 30189216, DOI: 10.1016/j.lfs.2018.09.006.Peer-Reviewed Original ResearchConceptsExercise training protocolFischer 344 ratsPhysical exerciseOld ratsShort-term exercise trainingNon-pharmacological therapeutic interventionsSkeletal muscleTraining protocolPossible therapeutic effectsAdiponectin receptor 1Old Fischer 344 ratsAge-related increaseGlucose intoleranceExercise trainingGlucose toleranceAdiponectin signalingTherapeutic effectTherapeutic interventionsAge-related deficitsReceptor 1RatsAkt phosphorylationReversal effectExerciseIsoform 1Acute physical exercise increases the adaptor protein APPL1 in the hypothalamus of obese mice
Gaspar R, Muñoz V, Formigari G, Kuga G, Nakandakari S, Botezelli J, da Silva A, Cintra D, de Moura L, Ropelle E, Pauli J. Acute physical exercise increases the adaptor protein APPL1 in the hypothalamus of obese mice. Cytokine 2018, 110: 87-93. PMID: 29705396, DOI: 10.1016/j.cyto.2018.04.013.Peer-Reviewed Original ResearchConceptsAcute physical exerciseObese micePhysical exerciseFood intakeArcuate proopiomelanocortin neuronsSerum adiponectin levelsProtein-3 levelsEffects of leptinCentral nervous systemRole of APPL1Proopiomelanocortin neuronsAdiponectin levelsAcute exerciseNervous systemHypothalamusPathophysiological processesAdiponectinAdaptor protein APPL1MiceProtein kinase BLeucine zipper motif 1Kinase BExerciseIntakeProtein content
2017
Overexpression of Mitogen-activated protein kinase phosphatase-3 (MKP-3) reduces FoxO1 phosphorylation in mice hypothalamus
de Almeida Rodrigues B, Kuga G, Muñoz V, Gaspar R, Tavares M, Botezelli J, da Silva A, Cintra D, de Moura L, Simabuco F, Ropelle E, Pauli J. Overexpression of Mitogen-activated protein kinase phosphatase-3 (MKP-3) reduces FoxO1 phosphorylation in mice hypothalamus. Neuroscience Letters 2017, 659: 14-17. PMID: 28866049, DOI: 10.1016/j.neulet.2017.08.067.Peer-Reviewed Original ResearchMeSH KeywordsAdenoviridaeAnimalsDual Specificity Phosphatase 6Forkhead Box Protein O1Genetic VectorsHypothalamusInsulinMicePhosphorylationProto-Oncogene Proteins c-aktConceptsFoxO1 phosphorylationMKP-3 overexpressionDephosphorylation of FOXO1Potential therapeutic targetInjection of adenovirusOrexigenic neuropeptidesHypothalamic disorderHypothalamic third ventricleSwiss miceInsulin intracellularHypothalamic activationThird ventricleTherapeutic targetFoxO1 dephosphorylationAkt phosphorylationInsulin signalingImportant transcription factorDUSP6 geneHypothalamusSignificant reductionFOXO1MiceInsulin stimulationPresent studyInsulin signalPhysical exercise reduces pyruvate carboxylase (PCB) and contributes to hyperglycemia reduction in obese mice
Muñoz V, Gaspar R, Crisol B, Formigari G, Sant’Ana M, Botezelli J, Gaspar R, da Silva A, Cintra D, de Moura L, Ropelle E, Pauli J. Physical exercise reduces pyruvate carboxylase (PCB) and contributes to hyperglycemia reduction in obese mice. The Journal Of Physiological Sciences 2017, 68: 493-501. PMID: 28710665, PMCID: PMC10717866, DOI: 10.1007/s12576-017-0559-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood GlucoseHyperglycemiaLiverMaleMiceMice, ObeseObesityPhosphorylationPhysical Conditioning, AnimalProto-Oncogene Proteins c-aktPyruvate CarboxylaseConceptsDiet-induced obesityObesity-inducing dietInsulin tolerance testObese micePhysical exerciseDIO miceExercise trainingControl miceHepatic tissueStandard rodent chowDevelopment of hyperglycemiaExercise training protocolType 2 diabetesTreadmill running protocolPhysical exercise sessionGlucose homeostasis controlEXE miceHyperglycemia reductionObese conditionsRodent chowTolerance testSerum glucoseSwiss miceExercise sessionsEpididymal fat