2020
Acute physical exercise increases PI3K‐p110α protein content in the hypothalamus of obese mice
Gaspar R, Nakandakari S, Muñoz V, Vieira R, da Silva A, Cintra D, de Moura L, Ropelle E, Pauli J. Acute physical exercise increases PI3K‐p110α protein content in the hypothalamus of obese mice. Journal Of Anatomy 2020, 238: 743-750. PMID: 33094520, PMCID: PMC7855078, DOI: 10.1111/joa.13342.Peer-Reviewed Original ResearchConceptsObese miceAcute exerciseFood intakePhysical exerciseCumulative food intakeBlood-brain barrierAcute physical exerciseEnergy homeostasis controlSuppressor of cytokineMain adipokinesHypothalamic nucleiPeripheral organsObese animalsLeptin signalingHypothalamusInsulin actionCentral signalingLeptinProtein levelsActivation of phosphoinositideMiceInsulin pathwayExerciseIntakeHomeostasis control
2018
Exercise decreases CLK2 in the liver of obese mice and prevents hepatic fat accumulation
Muñoz V, Gaspar R, Kuga G, Nakandakari S, Baptista I, Mekary R, da Silva A, de Moura L, Ropelle E, Cintra D, Pauli J. Exercise decreases CLK2 in the liver of obese mice and prevents hepatic fat accumulation. Journal Of Cellular Biochemistry 2018, 119: 5885-5892. PMID: 29575149, DOI: 10.1002/jcb.26780.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseObesity conditionsPrevention of NAFLDPhysical exerciseImpaired fat oxidationFatty liver diseaseMetabolic syndrome riskChronic physical exerciseHepatic fat accumulationAcid oxidationFatty acid oxidationObese groupLiver diseaseObese miceSwiss miceSyndrome riskFat accumulationObese animalsHepatic metabolismFat oxidationHepatic ketogenesisBeneficial effectsElevated levelsPotent strategyMice