2023
Baseline Features and Reasons for Nonparticipation in the Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM) Study, a Colorectal Cancer Screening Trial
Robertson D, Dominitz J, Beed A, Boardman K, Del Curto B, Guarino P, Imperiale T, LaCasse A, Larson M, Gupta S, Lieberman D, Planeta B, Shaukat A, Sultan S, Menees S, Saini S, Schoenfeld P, Goebel S, von Rosenvinge E, Baffy G, Halasz I, Pedrosa M, Kahng L, Cassim R, Greer K, Kinnard M, Bhatt D, Dunbar K, Harford W, Mengshol J, Olson J, Patel S, Antaki F, Fisher D, Sullivan B, Lenza C, Prajapati D, Wong H, Beyth R, Lieb J, Manlolo J, Ona F, Cole R, Khalaf N, Kahi C, Kohli D, Rai T, Sharma P, Anastasiou J, Hagedorn C, Fernando R, Jackson C, Jamal M, Lee R, Merchant F, May F, Pisegna J, Omer E, Parajuli D, Said A, Nguyen T, Tombazzi C, Feldman P, Jacob L, Koppelman R, Lehenbauer K, Desai D, Madhoun M, Tierney W, Ho M, Hockman H, Lopez C, Carter Paulson E, Tobi M, Pinillos H, Young M, Ho N, Mascarenhas R, Promrat K, Mutha P, Pandak W, Shah T, Schubert M, Pancotto F, Gawron A, Underwood A, Ho S, Magno-Pagatzaurtundua P, Toro D, Beymer C, Kaz A, Elwing J, Gill J, Goldsmith S, Yao M, Protiva P, Pohl H, Kyriakides T, Kleiner E, Sullivan K, O'Leary J, Chiu W, Huang H, Russo J, Johnson G, Antonelli P, Burns A, Peduzzi P, Ciarleglio M, O'Connor T, Wallace R, Williams A, Tommessilli L, Taylor S, Pitts S, Mancini L, O'Brien P, O'Neil S, Perry M, McBride V, Carr W, Joncas C, O'Donnell E, Sather M, Warren S, Conner T, Honstein E, Sutton T, Putnam T, Branham K, Argyres D, Peterson D, Kennedy A, Carrick T, Apodaca C, Eden G, Martinez T, Tripp C, Nicholson M, Schwartz A, Felix M, Ward A, Marquez L, Lovato K, Cochran N, Tapia S, VanRaden M, Badgett C, Taylor Z, Pontzer J, Dorman B, Chavez M, Georg S, Templton T, Calais L, Haakensen C, Curtis B, Prehoda M, Colling C, Older D, Apodaca G, Sova J, Klee M, Wolfram-Aduan A, Ulatowski M, Hamilton B, Bopp (Formerly England) K, Ford G, Lace N, McDonnell W, Piehl G, Patel-Ejarque N, Berry M, Strubeck E, Chesnut L, Burridge L, Bean J, Kowal L, Voorhees (Formerly Rose) A, Ridley A, Croteau H, Bessett K, Fletcher C, Barbaresso M, Drummond A, Belanger K, McRobert E, Myers A, Trumble E, Rose P, Biswas A, Enache E, Shankin M, Strunk D, Simpson A, Harrison M, Prasad M, Robinson P, Flores A, Jananeh S, Tanukonda S, Ahmadi-Izadi G, Madihi S, Raufman J, Grady D, Britton A, Goldstein C, Thomas M, Lee V, Belizaire M, Costa C, Davis S, Decker M, Marrama A, Gilroy-Fanaras D, Gass J, Reece S, Tobin D, Carroll R, Ferreira M, Irvin D, Morken V, Covelli M, Medina T, Schiebel F, Shreves A, Shriver D, Frederick Y, Postle (formerly Matheny) C, Shaw J, Pastor D, Armstrong A, Kumaran V, Pinto A, Marshall V, McLarty S, Carlton J, Murphy K, McLemore K, Mortensen E, LePage J, Willis C, Berman K, Dunn T, Espinoza J, Schleski E, Shrader S, Gropp K, Kanaan Z, Miller L, Anees M, Judd S, Berchou V, Balogh D, Jones E, Covert K, Davis Y, Marbury C, Rambus M, Olgren E, Gellad Z, Sullivan B, Day T, Teehan S, Peters L, Hernandez-Chavez R, Murphy E, Cherry J, Graham E, Johnson J, Wooten W, Trujillo J, Harris M, Alizadeh M, Lo M, Sultan S, Brown L, Koster L, LeLaurin J, Irwin A, Kay N, Mckillip S, Lowe M, Yeralan S, Leehey D, McBurney C, Jain A, Park T, Broadwater L, El-Serag H, Shaib Y, Taylor E, Nair P, Broussard E, Gibson E, Hawkins R, Natividad T, Courtade D, Palmer M, Martinez S, Panagiotis K, Morrow C, Ballard C, Barker B, Garner M, McCalley S, Schwartzkopf A, Wright A, Titi M, Higbee A, Pratiksha S, Jones A, Shipe T, McKee J, Vennalaganti R, Terrey K, Maruf L, Brown D, Crouse E, Marchant-Miros K, Ussery B, Ducker L, Estell J, Porchia S, Kim M, Kim C, Chan B, Hayton A, Christiansen H, Peterson M, Ding G, Simpson V, Read S, Mamani G, Salazar J, Kato J, Bowie M, Carnevale R, Halim M, Sahagian A, Ibarra A, Travis Z, Garcia J, Gill A, Starzyk J, Sumarli S, Johnson V, Peresuh S, Quimby T, Cordova R, Herold L, Hawley A, Goo T, Kidao J, Lee R, Freidel C, Gutierrez E, Noorisharghi N, Ivie G, Jawish T, Partin S, Yoo G, Fabilane C, Noori N, Lang E, Senen S, Partin S, Fathi M, Chauvin R, Feiger J, Reataza M, Morgan T, Asghar A, Jacobs J, Kashefi M, May F, Ohning G, Padua D, Smutko V, Oh D, Kosoyan H, Dreskin B, Luu K, Alas A, Bharath P, Dixit V, Sanford** D, Vu J, Kadi S, Nwajuaku T, Smith J, Kincaid J, Mir M, Lanceta J, Rice J, Agarwal P, Augustine A, Prickel H, Vue J, Guerrero K, Levenson S, Aguilera-Fish A, Chestnut L, Jobse B, Lombardo C, Silver T, Ahmed N, Bockhold K, Koppelman R, Carneiro F, Garcia-Morales R, Spector D, Gomez J, Lehenbauer K, Reinink A, Anway R, Evans-Lindquist M, Eggers T, Green M, Pretti A, Meyeraan T, Condon D, Cavanagh M, DeFalco C, Cutting J, Joseph K, Dean S, Mitchell S, Phillips V, Krueger C, Zink D, Goldberg K, Patel N, Martinez Gonzalez M, Davis-Underwood H, O'Sullivan A, Suppes T, Bratcher K, Stern D, Wu R, Damisa J, Warsi R, Nguyen T, Pinillos H, Flowers E, Kuramoto A, Thurmond C, Orozco L, Farrell G, Jaynes R, Saenz P, Perez C, Collins J, Lin E, Onstad L, Pitts A, Osborn K, Kenworthy-Heinige T, Casey A, Gold D, Olivo C, Joos S, Subramanian S, Forro V, Cannady A, Usih J, Raitt M, Flynn M, Shittu Y, Jawaid M, Anderson R, Poole D, Butler C, Snead L, Christine H, Swanson G, Heumann D, Pandak W, Spataro J, Bajaj J, Solomon C, Smith Gilles H, Zafass A, Tilak S, Fuchs M, Davis M, Blackman L, Lemler J, Munsey R, Deebo J, McCarthy J, Noel M, Hurley R, Zurowski W, Sharpe A, Wilson K, Peets R, Lorenso B, Burrison S, Johnson D, Angelovic A, Erickson N, Hanson H, Bailey T, Genung K, Dulin H, Neuharth R, Clegg D, Velarde K, Dever J, Murphy M, Beck D, Wasil M, Vazquez J, O'Neil E, Ganji G, Ducom J, Lee M, Hovespians R, Margolis J, Simmons B, Sweeney (formerly St. Martin) J, Henry R, Martin-Ortiz J, Santiago-Rivera L, Gonzalez - Aviles G, Pedrosa C, Bird-Caceres J, Padilla B, Baez-Corujo F, Martinez- Ortiz Y, Vazquez E, Grigg-Gutierrez N, Laboy-Olivieri C, Urbina-Velez R, Andrews S, Rosa-Cruz S, Tirado-Montijo R, Otero-Aponte K, Martinez-Martino M, Freire A, Soto-Ramos A, Santana-Perez M, Araujo J, Vanderwarker C, Alexander J, Nevins E, LaGuire J, Guerrero L, Piehl G, Jenkins M, Chen T, Jang J, Tanus A, McKelvy P, Sayuk G, Chandiramani P, Vargo (Formerly Shoults) L, Vargo K, Lawrence S, Blythe K, Goldsmith S, Campbell R, Craddock M, Amodeo D, Reinhard R, Durant B, Wells B, Zoble A, Papademetriou M, Roche N, Adler P, Krishna A, Glaze D, Wijegunawardana D, Yeroushalmi S, Laine L, Mautner R, Bugaj J, Anderson J, Croteau H, Kingman L, Burridge L. Baseline Features and Reasons for Nonparticipation in the Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM) Study, a Colorectal Cancer Screening Trial. JAMA Network Open 2023, 6: e2321730. PMID: 37432690, PMCID: PMC10336619, DOI: 10.1001/jamanetworkopen.2023.21730.Peer-Reviewed Original ResearchConceptsFecal immunochemical testImmunochemical testEligible individualsAnnual fecal immunochemical testColorectal Cancer Screening TrialScreening testVeterans Affairs Medical CenterAverage CRC riskCancer Screening TrialCancer mortality outcomesCross-sectional studySpecific screening testCase report formsColorectal Cancer StudyStudy participant characteristicsCross-sectional analysisStool testingCRC riskMortality outcomesColorectal cancerClinical trialsCONFIRM studyMedical CenterScreening preferencesHispanic ethnicity
2016
Calcium and 1,25-dihydroxyvitamin D3 modulate genes of immune and inflammatory pathways in the human colon: a human crossover trial 1–3
Protiva P, Pendyala S, Nelson C, Augenlicht LH, Lipkin M, Holt PR. Calcium and 1,25-dihydroxyvitamin D3 modulate genes of immune and inflammatory pathways in the human colon: a human crossover trial 1–3. American Journal Of Clinical Nutrition 2016, 103: 1224-1231. PMID: 27009752, PMCID: PMC4841933, DOI: 10.3945/ajcn.114.105304.Peer-Reviewed Original ResearchConceptsWestern-style dietCalcium supplementationInflammatory pathwaysImmune responseHuman colorectumAdequate vitamin D statusHigh dietary calcium intakeLower colorectal cancer riskClinical trial evidenceDietary calcium intakePrimary study endpointVitamin D statusColorectal cancer riskUrinary calcium concentrationD statusCalcium intakeUrinary calciumStudy endpointCrossover trialTrial evidenceBiopsy specimensColorectal mucosaTrial protocolColonic mucosaAdaptive immunity
2015
Quantification of Adequate Bowel Preparation for Screening or Surveillance Colonoscopy in Men
Clark BT, Protiva P, Nagar A, Imaeda A, Ciarleglio MM, Deng Y, Laine L. Quantification of Adequate Bowel Preparation for Screening or Surveillance Colonoscopy in Men. Gastroenterology 2015, 150: 396-405. PMID: 26439436, PMCID: PMC4728019, DOI: 10.1053/j.gastro.2015.09.041.Peer-Reviewed Original ResearchConceptsAdequate bowel preparationBBPS scoreSurveillance colonoscopyBowel preparationColon segmentsBBPS scoresSecond examinationWest Haven Veterans Affairs Medical CenterVeterans Affairs Medical CenterFirst examinationGuideline-recommended intervalsProspective observational studyDetection of adenomasIdentification of polypsColonoscopic evaluationPrimary outcomeSurveillance intervalsBlinded endoscopistsColonoscopy examinationObservational studyPrEP scaleMedical CenterInitial examinationStudy subjectsAdequate preparationUnder-reporting and Poor Adherence to Monitoring Guidelines for Severe Cases of Isoniazid Hepatotoxicity
Hayashi P, Fontana R, Chalasani N, Stolz A, Talwalkar J, Navarro V, Lee W, Davern T, Kleiner D, Gu J, Hoofnagle J, Investigators D, Chalasani N, Vuppalanchi R, Molleston J, Lumeng L, Corne A, Plummer A, Bonkovsky H, Protiva P, Freston J, Rosson R, Levine R, Maliakkal B, Appleton P, Smialek M, Fontana R, Conjeevaram H, Moseley R, Gordon S, Welch S, Worley J, Kridler J, Trivedi S, Kochlar S, Watkins P, Hayashi P, Russo M, Guess H, Beaver K, Smith A, Lewis J, Pusek S, Russell T, Mehltretter L, Davern T, Bonacini M, Partovi K, Fajardo K, Tai S, Lee W, Rockey D, Larson A, Grant L, Landgraf K, Stoltz A, Kaplowitz N, Milstein S, Talwalker J, Johnson S, Navarro V, Reddy R, Vega M, Wirjosemito A, Evans K, Rochon J, McHutchison J, Tilllmann H, Maggio M, Yang H, Galan K, Cosslin E, Sunas L, Collini M, Rose T, Crowder M, Scharenbroich C, Rostami H, Jiezhun S, Monroe T, Hammett A, Rosado N, Serrano J, Seeff L, Hoofnagle J, Toke D, Witt D, Higgins H, Kleiner D, Avigan M, Senior J. Under-reporting and Poor Adherence to Monitoring Guidelines for Severe Cases of Isoniazid Hepatotoxicity. Clinical Gastroenterology And Hepatology 2015, 13: 1676-1682.e1. PMID: 25724701, PMCID: PMC4653068, DOI: 10.1016/j.cgh.2015.02.024.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAdverse Drug Reaction Reporting SystemsAgedAntitubercular AgentsChemical and Drug Induced Liver InjuryChildChild, PreschoolDrug-Related Side Effects and Adverse ReactionsFemaleGuideline AdherenceHealth Services ResearchHumansIsoniazidMaleMiddle AgedProspective StudiesRetrospective StudiesUnited StatesYoung AdultConceptsLiver transplantationATS guidelinesIsoniazid hepatotoxicityLeading causeATS criteriaMeeting criteriaAmerican Thoracic Society guidelinesUnderwent liver transplantationThoracic Society guidelinesSeverity Index scoreCases of hepatotoxicityLatent tuberculosisMedian ageLiver injurySociety guidelinesPoor adherenceSevere outcomesInclusion criteriaSevere casesSevere injuriesIndex scoreHepatotoxicityAbstractTextMonitoring guidelinesPatients
2011
Aberrant crypt foci as predictors of colorectal neoplasia on repeat colonoscopy
Anderson JC, Swede H, Rustagi T, Protiva P, Pleau D, Brenner BM, Rajan TV, Heinen CD, Levine JB, Rosenberg DW. Aberrant crypt foci as predictors of colorectal neoplasia on repeat colonoscopy. Cancer Causes & Control 2011, 23: 355-361. PMID: 22187142, DOI: 10.1007/s10552-011-9884-7.Peer-Reviewed Original ResearchConceptsACF countRepeat colonoscopyColorectal neoplasiaFamily historyPrevious adenomaSurveillance colonoscopyColorectal cancerClinical surveillance guidelinesFuture advanced neoplasiaAdvanced colorectal neoplasiaAberrant crypt fociSections of colonACF frequencyConclusionsIncreased numberDistal colorectumPrior adenomasBaseline examinationSmoking historyAdvanced neoplasiaACF numberSub analysisSurveillance guidelinesSurveillance examsCrypt fociMAIN OUTCOMERisk Factors for Sessile Serrated Adenomas
Anderson JC, Rangasamy P, Rustagi T, Myers M, Sanders M, Vaziri H, Wu G, Birk JW, Protiva P. Risk Factors for Sessile Serrated Adenomas. Journal Of Clinical Gastroenterology 2011, 45: 694-699. PMID: 21325950, DOI: 10.1097/mcg.0b013e318207f3cf.Peer-Reviewed Original ResearchConceptsColorectal cancerTubular adenomaDiabetes mellitusRisk factorsPack-year exposureUse of aspirinSessile serrated adenomasCRC screeningFamily historyPatientsSerrated adenomasAdenomasMultivariate analysisMolecular abnormalitiesSmokersMellitusSmokingLesionsGroupNonsmokersSet of controlsStatinsObesityAspirinImportant pathwayAcute Hepatitis E Infection Accounts for Some Cases of Suspected Drug-Induced Liver Injury
Davern TJ, Chalasani N, Fontana RJ, Hayashi PH, Protiva P, Kleiner DE, Engle RE, Nguyen H, Emerson SU, Purcell RH, Tillmann HL, Gu J, Serrano J, Hoofnagle JH, Network D. Acute Hepatitis E Infection Accounts for Some Cases of Suspected Drug-Induced Liver Injury. Gastroenterology 2011, 141: 1665-1672.e9. PMID: 21855518, PMCID: PMC3654540, DOI: 10.1053/j.gastro.2011.07.051.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAcute Lung InjuryAdultAgedAged, 80 and overChemical and Drug Induced Liver InjuryDiagnosis, DifferentialFemaleHepatitis AntibodiesHepatitis EHepatitis E virusHumansImmunoglobulin GImmunoglobulin MMaleMiddle AgedPrevalenceProspective StudiesRetrospective StudiesUnited StatesConceptsDrug-induced liver injuryDrug-Induced Liver Injury NetworkAnti-HEV IgMAnti-HEV IgGLiver injuryHEV infectionAcute hepatitis E infectionHepatitis E virus infectionDrug-induced liver diseaseAcute hepatitis EAnti-HEV IgM.Acute viral hepatitisE virus infectionHepatitis E infectionViral hepatitis AAcute liver injuryHuman immunodeficiency virusE infectionHEV RNAClinical reassessmentHepatitis EViral hepatitisHepatitis AClinical featuresLiver diseaseAltered Folate Availability Modifies the Molecular Environment of the Human Colorectum: Implications for Colorectal Carcinogenesis
Protiva P, Mason JB, Liu Z, Hopkins ME, Nelson C, Marshall JR, Lambrecht RW, Pendyala S, Kopelovich L, Kim M, Kleinstein SH, Laird PW, Lipkin M, Holt PR. Altered Folate Availability Modifies the Molecular Environment of the Human Colorectum: Implications for Colorectal Carcinogenesis. Cancer Prevention Research 2011, 4: 530-543. PMID: 21321062, PMCID: PMC3742550, DOI: 10.1158/1940-6207.capr-10-0143.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiological AvailabilityCell Transformation, NeoplasticColonColorectal NeoplasmsDietary SupplementsDNA BreaksDNA MethylationFemaleFolic AcidFolic Acid DeficiencyGene ExpressionGene Expression ProfilingHumansMaleMiddle AgedOligonucleotide Array Sequence AnalysisPromoter Regions, GeneticRectumReverse Transcriptase Polymerase Chain ReactionTumor Suppressor Protein p53ConceptsFolate supplementationFolate deliveryFolate depletionImmune responseColorectal carcinogenesisDNA strand breaksHuman colonColorectal cancer riskFolic acidSupplemental folic acidLow-folate dietLow folate statusImmune response pathwaysImmune-related pathwaysFirst studyRectosigmoid biopsiesRisk volunteersPrimary endpointGene array analysisPromoter-specific DNA methylationRepletion protocolFolate dietFolate levelsSecond studyFolate status
2009
Chemoprevention of Colorectal Neoplasia by Estrogen: Potential Role of Vitamin D Activity
Protiva P, Cross HS, Hopkins ME, Kállay E, Bises G, Dreyhaupt E, Augenlicht L, Lipkin M, Lesser M, Livote E, Holt PR. Chemoprevention of Colorectal Neoplasia by Estrogen: Potential Role of Vitamin D Activity. Cancer Prevention Research 2009, 2: 43-51. PMID: 19139017, DOI: 10.1158/1940-6207.capr-08-0103.Peer-Reviewed Original ResearchMeSH Keywords25-Hydroxyvitamin D3 1-alpha-HydroxylaseChemopreventionColorectal NeoplasmsEstradiolEstrogen Replacement TherapyEstrogensFemaleGene ExpressionGene Expression ProfilingHumansMiddle AgedReceptors, CalcitriolReverse Transcriptase Polymerase Chain ReactionSteroid HydroxylasesVitamin DVitamin D3 24-HydroxylaseConceptsHormone replacement therapyVitamin D activityReplacement therapyPostmenopausal hormone replacement therapyVitamin D receptor pathwayPrimary end pointRectal mucosal biopsiesVitamin D actionExpression of VDRColon cancer incidenceE-cadherinRegulation of VDREstrogen interventionEstrogen-responsive genesPostmenopausal womenPremenopausal levelsVDR pathwayMucosal biopsiesRectal biopsySerum estradiolVitamin DColorectal neoplasiaD activityRectal mucosaCancer incidence
2008
Reliability of the Roussel Uclaf Causality Assessment Method for assessing causality in drug‐induced liver injury
Rochon J, Protiva P, Seeff LB, Fontana RJ, Liangpunsakul S, Watkins PB, Davern T, McHutchison JG, Network D. Reliability of the Roussel Uclaf Causality Assessment Method for assessing causality in drug‐induced liver injury. Hepatology 2008, 48: 1175-1183. PMID: 18798340, PMCID: PMC3618289, DOI: 10.1002/hep.22442.Peer-Reviewed Original ResearchConceptsRoussel Uclaf Causality Assessment MethodDrug-induced liver injuryCausality Assessment MethodLiver injuryDrug-induced liver injury casesDrug-Induced Liver Injury NetworkLiver injury casesCases of hepatotoxicityInterrater reliabilityStrength of associationDeviation ageCase of drugsTest-retest reliabilityTest-retest differencesCausality assessmentInjury casesInjuryFive-category scaleSame reviewersSame assessorPhenytoinReviewersIsoniazidAmoxicillinResearch settings