2012
Dietary Methyl Donor Depletion Protects Against Intestinal Tumorigenesis in ApcMin/+ Mice
Kadaveru K, Protiva P, Greenspan EJ, Kim YI, Rosenberg DW. Dietary Methyl Donor Depletion Protects Against Intestinal Tumorigenesis in ApcMin/+ Mice. Cancer Prevention Research 2012, 5: 911-920. PMID: 22677908, PMCID: PMC3397832, DOI: 10.1158/1940-6207.capr-11-0544.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkers, TumorCaloric RestrictionDietFolic AcidFolic Acid DeficiencyGene Expression ProfilingGenes, APCHumansIntestinal NeoplasmsMiceMice, Inbred C57BLOligonucleotide Array Sequence AnalysisReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSignal TransductionConceptsWeeks of ageIntestinal tumorigenesisCancer protectionNormal-appearing colonic mucosaMethyl donor statusSmall intestinal tumorsHigh-risk populationDietary folate supplementationVitamin B12 depletionColon cancer riskIntestinal tumor formationBody weight gainMD miceTumor numberTumor sizeMDS groupIntestinal tumorsColonic mucosaFolate supplementationProtective effectB12 depletionInflammatory signalingCancer riskDeficient dietFolate deficiency
2008
Growth inhibition of colon cancer cells by polyisoprenylated benzophenones is associated with induction of the endoplasmic reticulum response
Protiva P, Hopkins ME, Baggett S, Yang H, Lipkin M, Holt PR, Kennelly EJ, Bernard WI. Growth inhibition of colon cancer cells by polyisoprenylated benzophenones is associated with induction of the endoplasmic reticulum response. International Journal Of Cancer 2008, 123: 687-694. PMID: 18470880, DOI: 10.1002/ijc.23515.Peer-Reviewed Original ResearchMeSH KeywordsActivating Transcription Factor 4ApoptosisBenzophenonesCaspasesCell CycleCell Line, TumorCell SurvivalColonic NeoplasmsDNA-Binding ProteinsEndoplasmic ReticulumGarciniaGene Expression Regulation, NeoplasticHCT116 CellsHT29 CellsHumansInhibitory Concentration 50Linear ModelsMitochondrial MembranesNuclear ProteinsPrenylationProtein KinasesReactive Oxygen SpeciesRegulatory Factor X Transcription FactorsSignal TransductionTOR Serine-Threonine KinasesTranscription Factor CHOPTranscription FactorsUp-RegulationX-Box Binding Protein 1ConceptsEndoplasmic reticulum stress responseMitochondrial membrane potentialColon cancer cellsReticulum stress responseCaspase activationGene expressionStress responseSurvival pathwaysDDIT3/CHOPGuttiferone EEndoplasmic reticulum responseHuman colon cancer cellsParallel molecular pathwaysCell survival pathwaysCancer cellsCell linesMembrane potentialColon cancer cell linesHuman colon cancer cell linesREDD1 geneGene arrayMTOR survival pathwayCell cycleMolecular pathwaysCancer cell lines