2015
Under-reporting and Poor Adherence to Monitoring Guidelines for Severe Cases of Isoniazid Hepatotoxicity
Hayashi P, Fontana R, Chalasani N, Stolz A, Talwalkar J, Navarro V, Lee W, Davern T, Kleiner D, Gu J, Hoofnagle J, Investigators D, Chalasani N, Vuppalanchi R, Molleston J, Lumeng L, Corne A, Plummer A, Bonkovsky H, Protiva P, Freston J, Rosson R, Levine R, Maliakkal B, Appleton P, Smialek M, Fontana R, Conjeevaram H, Moseley R, Gordon S, Welch S, Worley J, Kridler J, Trivedi S, Kochlar S, Watkins P, Hayashi P, Russo M, Guess H, Beaver K, Smith A, Lewis J, Pusek S, Russell T, Mehltretter L, Davern T, Bonacini M, Partovi K, Fajardo K, Tai S, Lee W, Rockey D, Larson A, Grant L, Landgraf K, Stoltz A, Kaplowitz N, Milstein S, Talwalker J, Johnson S, Navarro V, Reddy R, Vega M, Wirjosemito A, Evans K, Rochon J, McHutchison J, Tilllmann H, Maggio M, Yang H, Galan K, Cosslin E, Sunas L, Collini M, Rose T, Crowder M, Scharenbroich C, Rostami H, Jiezhun S, Monroe T, Hammett A, Rosado N, Serrano J, Seeff L, Hoofnagle J, Toke D, Witt D, Higgins H, Kleiner D, Avigan M, Senior J. Under-reporting and Poor Adherence to Monitoring Guidelines for Severe Cases of Isoniazid Hepatotoxicity. Clinical Gastroenterology And Hepatology 2015, 13: 1676-1682.e1. PMID: 25724701, PMCID: PMC4653068, DOI: 10.1016/j.cgh.2015.02.024.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAdverse Drug Reaction Reporting SystemsAgedAntitubercular AgentsChemical and Drug Induced Liver InjuryChildChild, PreschoolDrug-Related Side Effects and Adverse ReactionsFemaleGuideline AdherenceHealth Services ResearchHumansIsoniazidMaleMiddle AgedProspective StudiesRetrospective StudiesUnited StatesYoung AdultConceptsLiver transplantationATS guidelinesIsoniazid hepatotoxicityLeading causeATS criteriaMeeting criteriaAmerican Thoracic Society guidelinesUnderwent liver transplantationThoracic Society guidelinesSeverity Index scoreCases of hepatotoxicityLatent tuberculosisMedian ageLiver injurySociety guidelinesPoor adherenceSevere outcomesInclusion criteriaSevere casesSevere injuriesIndex scoreHepatotoxicityAbstractTextMonitoring guidelinesPatients
2011
Acute Hepatitis E Infection Accounts for Some Cases of Suspected Drug-Induced Liver Injury
Davern TJ, Chalasani N, Fontana RJ, Hayashi PH, Protiva P, Kleiner DE, Engle RE, Nguyen H, Emerson SU, Purcell RH, Tillmann HL, Gu J, Serrano J, Hoofnagle JH, Network D. Acute Hepatitis E Infection Accounts for Some Cases of Suspected Drug-Induced Liver Injury. Gastroenterology 2011, 141: 1665-1672.e9. PMID: 21855518, PMCID: PMC3654540, DOI: 10.1053/j.gastro.2011.07.051.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAcute Lung InjuryAdultAgedAged, 80 and overChemical and Drug Induced Liver InjuryDiagnosis, DifferentialFemaleHepatitis AntibodiesHepatitis EHepatitis E virusHumansImmunoglobulin GImmunoglobulin MMaleMiddle AgedPrevalenceProspective StudiesRetrospective StudiesUnited StatesConceptsDrug-induced liver injuryDrug-Induced Liver Injury NetworkAnti-HEV IgMAnti-HEV IgGLiver injuryHEV infectionAcute hepatitis E infectionHepatitis E virus infectionDrug-induced liver diseaseAcute hepatitis EAnti-HEV IgM.Acute viral hepatitisE virus infectionHepatitis E infectionViral hepatitis AAcute liver injuryHuman immunodeficiency virusE infectionHEV RNAClinical reassessmentHepatitis EViral hepatitisHepatitis AClinical featuresLiver disease
2009
S1590 Immuno-Allergic (I-a) Manifestations of Drug-Induced Liver Injury (DILI) in the USA. Results from the Prospective Study of the DILI Network
Bonkovsky H, Agrawal S, Fontana R, Chalasani N, Watkins P, Davern T, Serrano J, Protiva P, Boling J, Rochon J, Kleiner D. S1590 Immuno-Allergic (I-a) Manifestations of Drug-Induced Liver Injury (DILI) in the USA. Results from the Prospective Study of the DILI Network. Gastroenterology 2009, 136: a-820. DOI: 10.1016/s0016-5085(09)63780-x.Peer-Reviewed Original Research
2008
Reliability of the Roussel Uclaf Causality Assessment Method for assessing causality in drug‐induced liver injury
Rochon J, Protiva P, Seeff LB, Fontana RJ, Liangpunsakul S, Watkins PB, Davern T, McHutchison JG, Network D. Reliability of the Roussel Uclaf Causality Assessment Method for assessing causality in drug‐induced liver injury. Hepatology 2008, 48: 1175-1183. PMID: 18798340, PMCID: PMC3618289, DOI: 10.1002/hep.22442.Peer-Reviewed Original ResearchConceptsRoussel Uclaf Causality Assessment MethodDrug-induced liver injuryCausality Assessment MethodLiver injuryDrug-induced liver injury casesDrug-Induced Liver Injury NetworkLiver injury casesCases of hepatotoxicityInterrater reliabilityStrength of associationDeviation ageCase of drugsTest-retest reliabilityTest-retest differencesCausality assessmentInjury casesInjuryFive-category scaleSame reviewersSame assessorPhenytoinReviewersIsoniazidAmoxicillinResearch settings