2000
Naltrexone-Induced Nausea in Patients Treated for Alcohol Dependence: Clinical Predictors and Evidence for Opioid-Mediated Effects
O'Malley S, Krishnan-Sarin S, Farren C, O'Connor P. Naltrexone-Induced Nausea in Patients Treated for Alcohol Dependence: Clinical Predictors and Evidence for Opioid-Mediated Effects. Journal Of Clinical Psychopharmacology 2000, 20: 69-76. PMID: 10653211, DOI: 10.1097/00004714-200002000-00012.Peer-Reviewed Original ResearchConceptsRisk of nauseaEndogenous opioid systemIntensity of drinkingSevere nauseaOpioid systemAlcohol useLight drinkersMost alcoholic patientsWeeks of naltrexoneOpen-label trialLong-term alcohol usePoor medication compliancePretreatment patient characteristicsLogistic regression analysisAlcohol-dependent subjectsDays of abstinenceDuration of abstinenceSignificant nauseaPatient characteristicsClinical predictorsEndogenous opioidsMedication complianceAlcoholic patientsNaltrexone doseRisk factors
1993
The impact of gender on clinical characteristics and outcome in alcohol withdrawal
O'Connor P, Horwitz R, Gottlieb L, Kraus M, Segal S. The impact of gender on clinical characteristics and outcome in alcohol withdrawal. Journal Of Substance Use And Addiction Treatment 1993, 10: 59-61. PMID: 8450575, DOI: 10.1016/0740-5472(93)90099-n.Peer-Reviewed Original ResearchConceptsSimilar treatment outcomesAlcohol withdrawalClinical featuresTreatment outcomesMean daily alcohol intakeHigh treatment failure rateTreatment failure rateDaily alcohol intakeTerms of baselineOutpatient withdrawalClinical characteristicsAlcohol intakeAlcohol abuseSociodemographic featuresPatientsWomenMenWithdrawalImpact of genderShort durationOutcomesTreatmentFailure rateGenderAlcoholism