2021
Late neurosyphilis and VZV meningoencephalitis coinfection
Carr K, Ogbuagu O. Late neurosyphilis and VZV meningoencephalitis coinfection. BMJ Case Reports 2021, 14: e240412. PMID: 34162599, PMCID: PMC8231027, DOI: 10.1136/bcr-2020-240412.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsCoinfectionHerpes ZosterHerpesvirus 3, HumanHumansMaleMeningoencephalitisMiddle AgedNeurosyphilisConceptsReactive Venereal Disease Research Laboratory testVenereal Disease Research Laboratory testCentral nervous system infectionDisease Research Laboratory testPrior cerebrovascular accidentSubtle neurologic symptomsNervous system infectionCerebrospinal fluid analysisIncidence of syphilisAcute meningoencephalitisDermatomal rashLate neurosyphilisLymphocytic pleocytosisHerpes zosterNeurologic symptomsSystem infectionCerebrovascular accidentMRI brainNeurological infectionsVirus PCRLumbar punctureUntreated infectionPossible associationImproved screeningFluid analysis
2019
Contemporary HCV pangenotypic DAA treatment protocols are exclusionary to real world HIV-HCV co-infected patients
Maughan A, Sadigh K, Angulo-Diaz V, Mandimika C, Villanueva M, Lim JK, Ogbuagu O. Contemporary HCV pangenotypic DAA treatment protocols are exclusionary to real world HIV-HCV co-infected patients. BMC Infectious Diseases 2019, 19: 378. PMID: 31053098, PMCID: PMC6500032, DOI: 10.1186/s12879-019-3974-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAminoisobutyric AcidsAnti-Retroviral AgentsAntiviral AgentsBenzimidazolesCarbamatesCoinfectionCyclopropanesDrug InteractionsFemaleHepacivirusHepatitis CHeterocyclic Compounds, 4 or More RingsHIV InfectionsHumansLactams, MacrocyclicLeucineLiver CirrhosisMaleMiddle AgedProlinePyrrolidinesQuinoxalinesSofosbuvirSulfonamidesTreatment OutcomeViral LoadConceptsHIV-HCVExclusion criteriaClinical trialsHIV-HCV co-infected patientsNew hepatitis C treatmentsHepatitis C virus infectionCo-infected patientsHIV patient populationC virus infectionGlecaprevir/pibrentasvirSofosbuvir/velpatasvirExcellent cure ratesHIV viral loadMajority of patientsHepatitis C treatmentInjection drug useReal-world populationART regimenHCV agentsCurrent regimensDecompensated cirrhosisViral loadPangenotypic activityCure ratePatient population