Angiotensin‐converting enzyme inhibition and smoking potentiate the kinin response to cardiopulmonary bypass
Pretorius M, McFarlane JA, Vaughan DE, Brown NJ, Murphey LJ. Angiotensin‐converting enzyme inhibition and smoking potentiate the kinin response to cardiopulmonary bypass. Clinical Pharmacology & Therapeutics 2004, 76: 379-387. PMID: 15470338, DOI: 10.1016/j.clpt.2004.06.004.Peer-Reviewed Original ResearchConceptsACE inhibitor groupMinutes of CPBCardiopulmonary bypassACE inhibitorsInhibitor groupKinin responseBradykinin concentrationsEffects of CPBCoronary artery bypass surgeryTissue-type plasminogen activator antigenPreoperative ACE inhibitorsArtery bypass surgeryPostoperative day 1Concentrations of bradykininEffect of smokingPlasminogen activator antigenKallikrein-kinin systemSignificant inverse correlationArterial pressureBypass surgeryFibrinolytic responseVenous bloodACE activityDay 1Enzyme inhibitors