α1A-Adrenergic receptor polymorphism
Xie H, Kim R, Stein C, Gainer J, Brown N, Wood A. α1A-Adrenergic receptor polymorphism. Pharmacogenetics And Genomics 1999, 9: 651-656. DOI: 10.1097/01213011-199910000-00012.Peer-Reviewed Original ResearchΑ1A-ARAfrican AmericansPrevalence of hypertensionPathogenesis of hypertensionVascular smooth muscleΑ1-adrenergic receptorsΑ1-adrenergic responsesCaucasian individualsEthnic differencesΑ1-AR subtypesVasoconstrictor sensitivityVascular reactivityBlood pressureEssential hypertensionHypertensive individualsVascular responsesVascular toneΑ1-ARReceptor polymorphismsSmooth muscleHypertensionSignificant intergenotypic differencesPotential roleRestriction fragment length polymorphismAllelic distribution