2024
Eosinophilia is a favorable marker for pneumonia in chronic obstructive pulmonary disease
Gu K, Jung J, Kang M, Kim D, Choi H, Cho Y, Jang S, Lee C, Oh Y, Park J, Kim J. Eosinophilia is a favorable marker for pneumonia in chronic obstructive pulmonary disease. Tuberculosis And Respiratory Diseases 2024, 87: 465-472. PMID: 38710525, PMCID: PMC11468446, DOI: 10.4046/trd.2023.0174.Peer-Reviewed Original ResearchCommunity-acquired pneumoniaChronic obstructive pulmonary diseaseCost of medical careObstructive pulmonary diseaseMedical careDuration of antibiotic treatmentReduced C-reactive protein levelsPneumonia Severity Index scorePulmonary diseaseCommunity-acquired pneumonia patientsC-reactive protein levelsHealth-care consumptionCohort study dataSeverity index scoreSeverity of pneumoniaPost hoc analysisClinical characteristicsAntibiotic treatmentFewer episodesEosinophiliaMulti-centerPatientsPneumonia patientsPneumoniaEosinophilic patientsEpidermal Growth Factor Receptor Regulates Beclin-1 in Hyperoxia-Induced Lung Injury
Harris Z, Sun Y, Korde A, Hu B, Sharma L, Manning E, Joerns J, Clark B, Stanley G, Shin H, Placek L, Unutmaz D, Chun H, Sauler M, Rajagopalan G, Zhang X, Wang H, Kang M, Koff J. Epidermal Growth Factor Receptor Regulates Beclin-1 in Hyperoxia-Induced Lung Injury. 2024, a6841-a6841. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a6841.Peer-Reviewed Original ResearchAlveolar Type 2 Cells With Impaired Proteostasis Signal to Monocyte-derived Macrophages Via a MIF/DDT-CD74 Signaling Network to Promotes Pulmonary Fibrosis in IPF
Kim S, Nouws J, Cooley J, Ahangari F, Leng L, Elias J, Kaminski N, Lee P, Redente E, Kang M, Sun H, Herzog E, Bucala R, Prasse A, Sauler M. Alveolar Type 2 Cells With Impaired Proteostasis Signal to Monocyte-derived Macrophages Via a MIF/DDT-CD74 Signaling Network to Promotes Pulmonary Fibrosis in IPF. 2024, a3001-a3001. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a3001.Peer-Reviewed Original Research
2023
The serotype-specific prevalence of pneumococci in hospitalized pneumonia patients with COPD: a prospective, multi-center, cohort study
Kim J, Jung J, Kang M, Kim D, Choi H, Cho Y, Jang S, Lee C, Oh Y, Park J. The serotype-specific prevalence of pneumococci in hospitalized pneumonia patients with COPD: a prospective, multi-center, cohort study. The Korean Journal Of Internal Medicine 2023, 38: 714-724. PMID: 37586811, PMCID: PMC10493435, DOI: 10.3904/kjim.2023.152.Peer-Reviewed Original ResearchConceptsCommunity-acquired pneumoniaSerotype-specific prevalencePneumococcal pneumoniaCohort studyS. pneumoniaeChronic obstructive pulmonary disease patientsPneumococcal polysaccharide vaccine 23Obstructive pulmonary disease patientsPCV-13 vaccinationUrine antigen detectionPulmonary disease patientsCommon pneumococcal serotypesPost-vaccination eraPneumococcal vaccinationSerotype 22FCOPD patientsInfluenza vaccinationPCV-13Clinical characteristicsVaccination statusOverall incidencePneumonia patientsPPV-23Pneumococcal serotypesVaccination ratesVISTA (PD-1H) Is a Crucial Immune Regulator to Limit Pulmonary Fibrosis.
Kim S, Adams T, Hu Q, Shin H, Chae G, Lee S, Sharma L, Kwon H, Lee F, Park H, Huh W, Manning E, Kaminski N, Sauler M, Chen L, Song J, Kim T, Kang M. VISTA (PD-1H) Is a Crucial Immune Regulator to Limit Pulmonary Fibrosis. American Journal Of Respiratory Cell And Molecular Biology 2023, 69: 22-33. PMID: 36450109, PMCID: PMC10324045, DOI: 10.1165/rcmb.2022-0219oc.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisPulmonary fibrosisImmune regulatorsTherapeutic potentialHuman idiopathic pulmonary fibrosisCrucial immune regulatorsNovel immune regulatorPulmonary fibrosis micePulmonary fibrosis modelNovel therapeutic targetRole of VISTAWild-type littermatesMonocyte-derived macrophagesT lymphocyte lineageVISTA expressionIPF treatmentAntibody treatmentImmune landscapeFibrotic mediatorsLung fibrosisFibrosis miceInflammatory responseFibrosis modelMyeloid populationsTherapeutic targetMAVS Dependent Immune Responses in Cigarette Smoke Exposure and Influenza Viral Infection
Gupta G, Cai C, Kim J, Kim S, Shin H, Kaminski N, Sharma L, Dela Cruz C, Kang M. MAVS Dependent Immune Responses in Cigarette Smoke Exposure and Influenza Viral Infection. 2023, a6747-a6747. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6747.Peer-Reviewed Original ResearchNLRX1 knockdown attenuates pro-apoptotic signaling and cell death in pulmonary hyperoxic acute injury
Kim H, Kim M, Kim E, Leem J, Baek S, Lee Y, Kim K, Kang M, Song T, Sohn M. NLRX1 knockdown attenuates pro-apoptotic signaling and cell death in pulmonary hyperoxic acute injury. Scientific Reports 2023, 13: 3441. PMID: 36859435, PMCID: PMC9975446, DOI: 10.1038/s41598-023-28206-x.Peer-Reviewed Original ResearchConceptsHyperoxic acute lung injuryAcute lung injuryLung injuryWT miceAcute respiratory failurePro-inflammatory cytokinesCell deathRespiratory failureAcute injuryInflammatory cellsReduced mortalityRole of NLRX1Murine modelNLRX1 expressionPro-apoptotic signalingCell cytotoxicityHyperoxiaInjuryMiceProtein leakageHyperoxic conditionsNLRX1Apoptotic cell deathERK 1/2Reactive oxygen species
2021
Nucleotide‐binding domain and leucine‐rich‐repeat‐containing protein X1 deficiency induces nicotinamide adenine dinucleotide decline, mechanistic target of rapamycin activation, and cellular senescence and accelerates aging lung‐like changes
Shin HJ, Kim S, Park H, Shin M, Kang I, Kang M. Nucleotide‐binding domain and leucine‐rich‐repeat‐containing protein X1 deficiency induces nicotinamide adenine dinucleotide decline, mechanistic target of rapamycin activation, and cellular senescence and accelerates aging lung‐like changes. Aging Cell 2021, 20: e13410. PMID: 34087956, PMCID: PMC8282248, DOI: 10.1111/acel.13410.Peer-Reviewed Original ResearchConceptsCellular senescenceActivation of mTORNucleotide-binding domainCellular senescence responseReplicative cellular senescenceNLR family membersOrganismal agingCellular physiologyMitochondrial moleculesSenescence responseCellular locationProtein X1Crucial regulatorMechanistic targetMitochondrial functionMolecular hallmarksNLRX1 functionRapamycin (mTOR) activationMitochondrial dysfunctionSenescenceMTORPharmacological inhibitionNLRX1BiologyAging LungInterleukin-13으로 유도된 폐 병태생리에 대한 atorvastatin의 치료 효과
Mo Y, Bae B, Kim J, Kim R, Son K, Kang M, Lee C, Cho S, Kang H. Interleukin-13으로 유도된 폐 병태생리에 대한 atorvastatin의 치료 효과. Allergy Asthma & Respiratory Disease 2021, 9: 76-83. DOI: 10.4168/aard.2021.9.2.76.Peer-Reviewed Original Research
2020
Retrograde signaling by a mtDNA-encoded non-coding RNA preserves mitochondrial bioenergetics
Blumental-Perry A, Jobava R, Bederman I, Degar A, Kenche H, Guan B, Pandit K, Perry N, Molyneaux N, Wu J, Prendergas E, Ye Z, Zhang J, Nelson C, Ahangari F, Krokowski D, Guttentag S, Linden P, Townsend D, Miron A, Kang M, Kaminski N, Perry Y, Hatzoglou M. Retrograde signaling by a mtDNA-encoded non-coding RNA preserves mitochondrial bioenergetics. Communications Biology 2020, 3: 626. PMID: 33127975, PMCID: PMC7603330, DOI: 10.1038/s42003-020-01322-4.Peer-Reviewed Original ResearchConceptsMitochondrial genomeNuclear-encoded genesCell type-specific mannerNon-coding RNASteady-state transcriptionMitochondrial energy metabolismControl regionPositive regulationMitochondrial bioenergeticsMitochondria stressMitochondrial functionSpecific mannerAlveolar epithelial type II cellsEnergy metabolismType II cellsEpithelial type II cellsGenomePhysiological stressRNAII cellsCellsMouse lungTranscriptionGenesMitochondriaSmoking Alters Inflammation and Skeletal Stem and Progenitor Cell Activity During Fracture Healing in Different Murine Strains
Hao Z, Li J, Li B, Alder KD, Cahill SV, Munger AM, Lee I, Kwon H, Back J, Xu S, Kang M, Lee FY. Smoking Alters Inflammation and Skeletal Stem and Progenitor Cell Activity During Fracture Healing in Different Murine Strains. Journal Of Bone And Mineral Research 2020, 36: 186-198. PMID: 32866293, PMCID: PMC9057220, DOI: 10.1002/jbmr.4175.Peer-Reviewed Original ResearchConceptsCigarette smoke exposureCigarette smokingFracture healingSmoke exposureMurine modelMolecular alterationsBALB/cJ miceBiomechanical testingPro-inflammatory mediatorsCytokine/chemokine analysisImpaired fracture healingMultiplex cytokine/chemokine analysisInitial inflammatory responseFracture healing capacityBALB/cJProgenitor cell activitySmoking miceTransverse femoral osteotomyFemoral osteotomyImmune cellsChemokine analysisInflammatory responseFracture hematomaHigh riskMurine strainsRetrograde Signaling by Mitochondria-Encoded Mito-ncR-805 Preserves Mitochondrial Function of Alveolar Epithelial Type 2 Cells During Exposure to Cigarette Smoke
Blumental-Perry A, Jobava R, Guan B, Bederman I, Ye Z, Perry N, Molyneaux N, Wu J, Guttentag S, Townsend D, Miron A, Kang M, Shadel G, Kaminski N, Perry Y, Hatzoglou M. Retrograde Signaling by Mitochondria-Encoded Mito-ncR-805 Preserves Mitochondrial Function of Alveolar Epithelial Type 2 Cells During Exposure to Cigarette Smoke. 2020, a6384-a6384. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6384.Peer-Reviewed Original ResearchRecent Advances in Molecular Basis of Lung Aging and Its Associated Diseases
Kang M. Recent Advances in Molecular Basis of Lung Aging and Its Associated Diseases. Tuberculosis And Respiratory Diseases 2020, 83: 107-115. PMID: 32185913, PMCID: PMC7105435, DOI: 10.4046/trd.2020.0003.Peer-Reviewed Original ResearchAging-related lung disordersLung disordersChronic obstructive pulmonary diseaseMajor unmet medical needObstructive pulmonary diseaseChronic lung disordersIdiopathic pulmonary fibrosisMolecular basisMolecular featuresBiological functionsUnmet medical needMolecular mechanismsCrucial risk factorMolecular understandingMolecular biologyBiologyPulmonary diseaseLung agingPulmonary fibrosisRisk factorsAdvanced agePulmonary medicineAssociated diseaseMedical needProgressive decline
2011
Poly(I:C) And RIG-Like Helicase Regulation Of Pulmonary Melanoma Metastasis
Ma B, Cruz C, Kang M, Takyar S, Homer R, Lee C, Elias J. Poly(I:C) And RIG-Like Helicase Regulation Of Pulmonary Melanoma Metastasis. 2011, a1323-a1323. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a1323.Peer-Reviewed Original Research
2010
Transgenic modelling of cytokine polarization in the lung
Dela Cruz CS, Kang M, Cho W, Lee CG. Transgenic modelling of cytokine polarization in the lung. Immunology 2010, 132: 9-17. PMID: 21091906, PMCID: PMC3015070, DOI: 10.1111/j.1365-2567.2010.03376.x.Peer-Reviewed Original ResearchConceptsCytokine polarizationT helper type 17 cytokinesT helper type 2T helper type 1Type 1Type 17 cytokinesHelper type 2Type 2 cytokinesHelper type 1Human lung diseasesVariety of cytokinesCytokine milieuPulmonary inflammationEnvironmental allergensLung diseaseTissue phenotypeInjury modelT-betCommon siteCertain cytokinesEffector functionsTransgenic miceIndividual cytokinesPathophysiological consequencesType 2Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthma
Koh BH, Hwang SS, Kim JY, Lee W, Kang MJ, Lee CG, Park JW, Flavell RA, Lee GR. Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 10614-10619. PMID: 20483988, PMCID: PMC2890814, DOI: 10.1073/pnas.1005383107.Peer-Reviewed Original ResearchConceptsCD4 T cellsAllergic asthmaTh2 cytokine genesCytokine genesKO miceT cellsNaïve CD4 T cellsLung airway inflammationSerum IgE levelsBronchoalveolar lavage fluidRecruitment of eosinophilsWild-type miceAirway hyperresponsivenessOvalbumin challengeAirway inflammationIgE levelsLavage fluidTh2 cytokinesAirway wallMucus productionMouse modelAsthmaMarked reductionCre-loxP recombinationMiceCigarette Smoke Causes Lung Vascular Endothelial Cell Apoptosis And Activation Of Unfolded Protein Response And Autophagy
Lu Q, Newton J, Ortiz M, Kang M, Lee C, Elias J, Harrington E, Rounds S. Cigarette Smoke Causes Lung Vascular Endothelial Cell Apoptosis And Activation Of Unfolded Protein Response And Autophagy. 2010, a3449-a3449. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a3449.Peer-Reviewed Original ResearchCigarette Smoke Causes Lung Vascular Endothelial Cell Apoptosis And Alterations Of TGF-²1 Signaling
Lu Q, Newton J, Kang M, Lee C, Elias J, Harrington E, Rounds S. Cigarette Smoke Causes Lung Vascular Endothelial Cell Apoptosis And Alterations Of TGF-²1 Signaling. 2010, a3448-a3448. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a3448.Peer-Reviewed Original ResearchInnate Immune RIG-like Helicase (RLH) Pathway Activation Inhibits VEGF-Induced Vascular And Angiogenic Responses
Ma B, Lee C, Dela Cruz C, Kang M, Takyar S, Homer R, Elias J. Innate Immune RIG-like Helicase (RLH) Pathway Activation Inhibits VEGF-Induced Vascular And Angiogenic Responses. 2010, a1067-a1067. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1067.Peer-Reviewed Original Research
2009
Cigarette Smoke Enhances poly(I:C)-Induced Innate Immune and Remodeling Responses Via a RIG-1 like Helicase, Mitochondrial Antiviral Signaling Protein (MAVS)-Dependent Mechanism.
Kang M, Lee C, Lee J, Dela Cruz C, Chen Z, Enelow R, Elias J. Cigarette Smoke Enhances poly(I:C)-Induced Innate Immune and Remodeling Responses Via a RIG-1 like Helicase, Mitochondrial Antiviral Signaling Protein (MAVS)-Dependent Mechanism. 2009, a4264. DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a4264.Peer-Reviewed Original Research