2000
Synectin, syndecan‐4 cytoplasmic domain binding PDZ protein, inhibits cell migration
Gao Y, Li M, Chen W, Simons M. Synectin, syndecan‐4 cytoplasmic domain binding PDZ protein, inhibits cell migration. Journal Of Cellular Physiology 2000, 184: 373-379. PMID: 10911369, DOI: 10.1002/1097-4652(200009)184:3<373::aid-jcp12>3.0.co;2-i.Peer-Reviewed Original ResearchConceptsSyndecan-4Cytoplasmic domainSyndecan-4 cytoplasmic domainTwo-hybrid libraryDomain-mediated interactionsNovel binding partnerInhibits cell migrationGene familyPDZ proteinsBinding partnerDependent regulationSynectinImportant regulatorCell adhesionCell migrationCell growthGrowth rateGIPCMigrationRegulatorDomainProteinTransportersOverexpressionNeuropilins
1999
Cloning, Expression, andin VitroActivity of Human Endostatin
Dhanabal M, Volk R, Ramchandran R, Simons M, Sukhatme V. Cloning, Expression, andin VitroActivity of Human Endostatin. Biochemical And Biophysical Research Communications 1999, 258: 345-352. PMID: 10329390, DOI: 10.1006/bbrc.1999.0595.Peer-Reviewed Original Research
1998
Effects of coronary artery disease on expression and microvascular response to VEGF
Métais C, Li J, Li J, Simons M, Sellke F. Effects of coronary artery disease on expression and microvascular response to VEGF. American Journal Of Physiology 1998, 275: h1411-h1418. PMID: 9746492, DOI: 10.1152/ajpheart.1998.275.4.h1411.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine DiphosphateCell DivisionCoronary Artery BypassCoronary DiseaseEndothelial Growth FactorsEndothelium, VascularFemaleGene Expression RegulationGenisteinHeart AtriaHepatocyte Growth FactorHumansIn Vitro TechniquesKineticsLymphokinesMaleMicrocirculationMicroscopy, VideoMiddle AgedMuscle RelaxationMuscle, Smooth, VascularNitric Oxide SynthaseNitric Oxide Synthase Type IINitric Oxide Synthase Type IIINitroarginineProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesReceptors, Growth FactorReceptors, MitogenReceptors, Vascular Endothelial Growth FactorRNA, MessengerTranscription, GeneticVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth FactorsVasodilationConceptsCoronary artery diseaseInducible nitric oxide synthaseConstitutive nitric oxide synthaseVascular endothelial growth factorHepatocyte growth factorExpression of VEGFNitric oxide synthaseArtery diseaseNG-nitroMicrovascular responsesOxide synthaseExpression of cNOSL-arginineGrowth factorCoronary microvascular responsesSubstance P responseExogenous vascular endothelial growth factorEndothelial growth factorFlk-1 receptorFlt-1 receptorMild hypercholesterolemiaTyrosine kinase receptorsTyrosine kinase inhibitor genisteinEndothelium dysfunctionVascular responses
1997
c-Myb-dependent cell cycle progression and Ca2+ storage in cultured vascular smooth muscle cells.
Husain M, Bein K, Jiang L, Alper S, Simons M, Rosenberg R. c-Myb-dependent cell cycle progression and Ca2+ storage in cultured vascular smooth muscle cells. Circulation Research 1997, 80: 617-26. PMID: 9130442, DOI: 10.1161/01.res.80.5.617.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsCultured vascular smooth muscle cellsSmooth muscle cellsCell cycle progressionMuscle cellsCycle progressionCell populationsC-myb expressionC-MybReleasable Ca2G1/S interfaceCytoplasmic Ca2C-Myb activityGrowth factorCell clonesCell proliferationProgressionSignificant reductionStable cell clonesProto-oncogeneTransient inductionC-myb proto-oncogeneS-phase entryCa2Growth-arrested cellsEnhancement of Migration by Protein Kinase Cα and Inhibition of Proliferation and Cell Cycle Progression by Protein Kinase Cδ in Capillary Endothelial Cells*
Harrington E, Löffler J, Nelson P, Kent K, Simons M, Ware J. Enhancement of Migration by Protein Kinase Cα and Inhibition of Proliferation and Cell Cycle Progression by Protein Kinase Cδ in Capillary Endothelial Cells*. Journal Of Biological Chemistry 1997, 272: 7390-7397. PMID: 9054439, DOI: 10.1074/jbc.272.11.7390.Peer-Reviewed Original Research
1996
…and surreal antisense?
Simons M, Rosenberg R, Edelman E. …and surreal antisense? Nature Medicine 1996, 2: 131-132. PMID: 8574948, DOI: 10.1038/nm0296-131b.Peer-Reviewed Original Research
1995
c-myc in Vasculoproliferative Disease
Edelman E, Simons M, Sirois M, Rosenberg R. c-myc in Vasculoproliferative Disease. Circulation Research 1995, 76: 176-182. PMID: 7834827, DOI: 10.1161/01.res.76.2.176.Peer-Reviewed Original Research
1992
Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo
Simons M, Edelman E, DeKeyser J, Langer R, Rosenberg R. Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo. Nature 1992, 359: 67-70. PMID: 1522889, DOI: 10.1038/359067a0.Peer-Reviewed Original Research