2012
Frs2 via fibroblast growth factor receptor 1 is required for platelet-derived growth factor receptor β-mediated regulation of vascular smooth muscle marker gene expression.
Chen P, Simons M, Friesel R. Frs2 via fibroblast growth factor receptor 1 is required for platelet-derived growth factor receptor β-mediated regulation of vascular smooth muscle marker gene expression. Journal Of Biological Chemistry 2012, 287: 1609. PMCID: PMC3256868, DOI: 10.1074/jbc.a111.809399.Peer-Reviewed Original Research
2008
Arterial branching morphogenesis
Simons M. Arterial branching morphogenesis. The FASEB Journal 2008, 22: 520.1-520.1. DOI: 10.1096/fasebj.22.1_supplement.520.1.Peer-Reviewed Original ResearchVariety of signalsArterial morphogenesisArterial differentiationBranching morphogenesisEmbryonic developmentZebrafish modelPDGF stimulationOrgan growthAdult tissuesGene expressionIntracellular signalingMorphogenesisCell typesMolecular defectsTree sizeKey eventsEndothelial cellsRegulationAbnormal activationKey roleObvious importanceActivationSynectinRac1Signaling
2000
Inhibition of ubiquitin-proteasome pathway–mediated IκBα degradation by a naturally occurring antibacterial peptide
Gao Y, Lecker S, Post M, Hietaranta A, Li J, Volk R, Li M, Sato K, Saluja A, Steer M, Goldberg A, Simons M. Inhibition of ubiquitin-proteasome pathway–mediated IκBα degradation by a naturally occurring antibacterial peptide. Journal Of Clinical Investigation 2000, 106: 439-448. PMID: 10930447, PMCID: PMC314329, DOI: 10.1172/jci9826.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Infective AgentsAntimicrobial Cationic PeptidesCells, CulturedCysteine EndopeptidasesDNA-Binding ProteinsGene ExpressionHumansI-kappa B ProteinsMaleMiceMice, Inbred ICRMice, TransgenicMultienzyme ComplexesMyocardial InfarctionNF-kappa BNF-KappaB Inhibitor alphaPancreatitisPeptidesProteasome Endopeptidase ComplexSwineUbiquitinsConceptsDependent gene expressionGene expressionNF-kappa BUbiquitin-proteasome pathwayB alpha phosphorylationValosin-containing proteinB alpha degradationNF-kappa B inhibitor ICellular functionsTranscription factorsAlpha phosphorylationBiological processesInhibitor IAlpha 7 subunitSelective regulationProteasome activityB alphaAntibacterial peptidesOverall proteasome activityAlpha degradationNF-kappaBCell culturesIκBα degradationExpressionPeptides
1999
Myocyte-dependent Regulation of Endothelial Cell Syndecan-4 Expression ROLE OF TNF-α*
Zhang Y, Pasparakis M, Kollias G, Simons M. Myocyte-dependent Regulation of Endothelial Cell Syndecan-4 Expression ROLE OF TNF-α*. Journal Of Biological Chemistry 1999, 274: 14786-14790. PMID: 10329676, DOI: 10.1074/jbc.274.21.14786.Peer-Reviewed Original ResearchConceptsSyndecan-4 expressionECV cellsProtein kinase C alphaCardiac myocytesGene familySyndecan-4 mRNATNF-alphaPosttranscriptional mechanismsGene expressionPrimary cardiac myocytesUnique memberC alphaHuman endothelial cellsSyndecan-4Western analysisMouse cardiac myocytesSyndecan-4 levelsNormal myoblastsDependent mannerNF-kappaBExpressionH9c2 cellsHypoxic conditionsTumor necrosisEndothelial cells
1997
Macrophage-dependent regulation of syndecan gene expression.
Li J, Brown L, Laham R, Volk R, Simons M. Macrophage-dependent regulation of syndecan gene expression. Circulation Research 1997, 81: 785-96. PMID: 9351452, DOI: 10.1161/01.res.81.5.785.Peer-Reviewed Original ResearchConceptsBlood-derived macrophagesSyndecan expressionSyndecan geneMyocardial infarctionGene expressionRegulation of expressionSyndecan-1Op/op miceGranulocyte-macrophage colony-stimulating factorMacrophage colony-stimulating factorRat infarct modelColony-stimulating factorHeparin-binding growth factorsSyndecan-4 mRNASyndecan-1 mRNABiological processesMacrophage influxCellular responsesMacrophage contentSyndecan-4Right ventricleTissue injuryOp miceExtracellular matrixPrompt increase
1991
Assessement of restenosis vs primary lesions in patients with peripheral vascular disease using in situ hybridization and gene expression of two nonmuscle myosin isoforms
Leclerc G, Weir L, Simons M, Kearney M, Rosenfield K, Isner J. Assessement of restenosis vs primary lesions in patients with peripheral vascular disease using in situ hybridization and gene expression of two nonmuscle myosin isoforms. Journal Of The American College Of Cardiology 1991, 17: a105. DOI: 10.1016/0735-1097(91)91387-t.Peer-Reviewed Original Research