2001
Efficacy of intracoronary or intravenous VEGF165 in a pig model of chronic myocardial ischemia
Sato K, Wu T, Laham R, Johnson R, Douglas P, Li J, Sellke F, Bunting S, Simons M, Post M. Efficacy of intracoronary or intravenous VEGF165 in a pig model of chronic myocardial ischemia. Journal Of The American College Of Cardiology 2001, 37: 616-623. PMID: 11216988, DOI: 10.1016/s0735-1097(00)01144-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCoronary CirculationDose-Response Relationship, DrugEndothelial Growth FactorsEndothelium, VascularInfusions, Intra-ArterialInfusions, IntravenousLymphokinesMaleMicrocirculationMyocardial ContractionMyocardial IschemiaSwineVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsChronic myocardial ischemiaMyocardial ischemiaL-NAMEIntracoronary groupBlood flowNitro-L-arginine methyl ester hydrochlorideNitric oxide synthase inhibitionEndothelial growth factor treatmentLeft circumflex coronary arteryDose-limiting hypotensionOxide synthase inhibitionCircumflex coronary arteryVascular endothelial growth factor treatmentMyocardial blood flowRegional myocardial functionGrowth factor treatmentVEGF-induced angiogenesisIntravenous groupConcomitant administrationMicrovascular functionIntracoronary infusionCollateral indexDifferent regimensCoronary arteryIntravenous infusion
1996
Angiogenesis induced by acidic fibroblast growth factor as an alternative method of revascularization for chronic myocardial ischemia
Sellke F, Li J, Stamler A, Lopez J, Thomas K, Simons M. Angiogenesis induced by acidic fibroblast growth factor as an alternative method of revascularization for chronic myocardial ischemia. Surgery 1996, 120: 182-188. PMID: 8751581, DOI: 10.1016/s0039-6060(96)80286-8.Peer-Reviewed Original ResearchConceptsCollateral-dependent LCx regionAcidic fibroblast growth factorFibroblast growth factorLCx regionBlood flowSodium nitroprussideProximal left circumflex coronary arterySevere coronary artery diseaseLeft circumflex coronary arteryGrowth factorCoronary arterial microvesselsCoronary microvascular reactivityProximal (<b>d</b>) LCX arteryEndothelium-dependent mechanismEndothelium-dependent relaxationCircumflex coronary arteryCollateral-dependent myocardiumCoronary artery diseaseTreatment of patientsGuanylate cyclase activators sodium nitroprussideChronic myocardial ischemiaAdenylate cyclase activator forskolinPeriadventitial administrationCyclase activator forskolinMicrovascular reactivity
1995
β-Adrenergic Modulation of the Collateral-Dependent Coronary Microcirculation
Sellke F, Wang S, Friedman M, Bin Dai H, Harada K, Lopez J, Simons M. β-Adrenergic Modulation of the Collateral-Dependent Coronary Microcirculation. Journal Of Surgical Research 1995, 59: 185-190. PMID: 7630126, DOI: 10.1006/jsre.1995.1152.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factorCollateral-dependent LCx regionLCx regionCoronary microcirculationBlood flowProximal left circumflex coronary arteryLeft circumflex coronary arteryCollateral-dependent areaCollateral-dependent perfusionCoronary arterial microvesselsCoronary microvascular responsesLCX blood flowProximal (<b>d</b>) LCX arteryCircumflex coronary arteryCollateral-dependent myocardiumRapid atrial pacingEndothelial growth factorΒ-Adrenergic ModulationAdenylate cyclase activator forskolinRelaxations of microvesselsCyclase activator forskolinChronic treatmentLeft anteriorMicrovascular relaxationAtrial pacing