2001
Serial Motion Assessment by Reference Tracking (SMART): Application to Detection of Local Functional Impact of Chronic Myocardial Ischemia
Pearlman J, Gertz Z, Wu Y, Simons M, Post M. Serial Motion Assessment by Reference Tracking (SMART): Application to Detection of Local Functional Impact of Chronic Myocardial Ischemia. Journal Of Computer Assisted Tomography 2001, 25: 558-562. PMID: 11473185, DOI: 10.1097/00004728-200107000-00008.Peer-Reviewed Original ResearchPharmacokinetics and Pharmacodynamics of Recombinant FGF‐2 in a Phase I Trial in Coronary Artery Disease
Bush M, Samara E, Whitehouse MJ, Yoshizawa C, Novicki D, Pike M, Laham R, Simons M, Chronos N. Pharmacokinetics and Pharmacodynamics of Recombinant FGF‐2 in a Phase I Trial in Coronary Artery Disease. The Journal Of Clinical Pharmacology 2001, 41: 378-385. PMID: 11304894, DOI: 10.1177/00912700122010230.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overArea Under CurveCoronary DiseaseEnzyme-Linked Immunosorbent AssayFemaleFibroblast Growth Factor 2Follow-Up StudiesHemodynamicsHeparinHumansInfusions, IntravenousMaleMaximum Tolerated DoseMetabolic Clearance RateMiddle AgedRecombinant ProteinsRegression AnalysisTime FactorsConceptsRecombinant FGF-2Coronary artery diseasePhase I trialFibroblast growth factor-2Artery diseaseI trialSystemic exposureSevere coronary artery diseaseTerminal elimination t1/2Peak plasma concentrationConcentration-time curveMultiple animal modelsDose-response relationshipAcute hemodynamicsGrowth factor 2Chronic ischemiaElimination t1/2Intravenous infusionSingle doseLinear pharmacokineticsDistribution t1/2Plasma concentrationsIntravenous administrationBiphasic eliminationSlow clearance
1996
Local Extravascular Growth Factor Delivery in Myocardial Ischemia
Lopez J, Simons M. Local Extravascular Growth Factor Delivery in Myocardial Ischemia. Drug Delivery 1996, 3: 143-147. PMID: 26790909, DOI: 10.3109/10717549609029443.Peer-Reviewed Original ResearchBasic fibroblast growth factorVascular endothelial growth factorIschemic myocardiumGrowth factorCoronary collateral circulationNumber of microvesselsNon-ischemic myocardiumImplantable osmotic pumpMyocardial blood flowPerivascular drug deliveryEndothelial growth factorAngiogenic growth factorsFibroblast growth factorCollateral circulationChronic ischemiaMyocardial performanceMyocardial ischemiaVEGF administrationHeart sectionsBlood flowControl animalsMyocardial perfusionOsmotic pumpControl groupExogenous growth factor delivery