2007
THE ANTI‐ANGIOGENIC ACTIVITY OF rPAI‐123 INHIBITS ANGIOGENIC VASA VASORUM AND ATHERSCLEROTIC PLAQUE GROWTH
Mulligan‐Kehoe M, Drinane M, Mollmark J, Simons M. THE ANTI‐ANGIOGENIC ACTIVITY OF rPAI‐123 INHIBITS ANGIOGENIC VASA VASORUM AND ATHERSCLEROTIC PLAQUE GROWTH. The FASEB Journal 2007, 21: a16-a17. DOI: 10.1096/fasebj.21.5.a16-d.Peer-Reviewed Original ResearchHigh-fat dietAnti-angiogenic activityVasa vasorumPlaque growthSaline treatmentPlaque areaPlaque progressionLumen areaRole of angiogenesisVasa vasorum densitySignificant anti-angiogenic activityAtherogenic micePlaque regressionHFD groupNeovascularized areaChow dietPAI-1 proteinFat dietAortic rootControl animalsVessel circumferenceVasorumVessel areaMiceReconstructed vessels
2006
Granzyme B‐dependent Matrix Degradation Generates Anti‐Angiostatic Activity in Scleroderma Patients
Mulligan‐Kehoe M, Drinane M, Hummers L, Hall A, Rosen A, Wigley F, Simons M. Granzyme B‐dependent Matrix Degradation Generates Anti‐Angiostatic Activity in Scleroderma Patients. The FASEB Journal 2006, 20: a1099-a1099. DOI: 10.1096/fasebj.20.5.a1099-a.Peer-Reviewed Original ResearchSSc patientsRA patientsScleroderma patientsGranzyme BSystemic connective tissue diseasesExtensive vascular componentConnective tissue diseasePAI-1 levelsNormal control patientsAngiostatin K1-3Impaired wound healingAnti-angiogenic factorsAnti-angiogenic activityNormal endothelial cellsAberrant microvasculatureControl patientsRheumatoid arthritisTissue diseaseVascular abnormalitiesUncertain etiologyVascular componentPatientsEndothelial cellsEndothelial cell migrationWound healing