2024
Short versus 1-Year Dual Antiplatelet Therapy after Percutaneous Coronary Intervention: An Updated Systematic Review and Meta-Analysis
Joseph M, Krishna M, Ezenna C, Pereira V, Ismayl M, Nanna M, Bangalore S, Goldsweig A. Short versus 1-Year Dual Antiplatelet Therapy after Percutaneous Coronary Intervention: An Updated Systematic Review and Meta-Analysis. The American Journal Of Cardiology 2024 PMID: 39577682, DOI: 10.1016/j.amjcard.2024.10.038.Peer-Reviewed Original ResearchPost-percutaneous coronary interventionAcute coronary syndromeDrug-eluting stentsPercutaneous coronary interventionCoronary interventionAcute coronary syndrome cohortCochrane Central databasesShortening DAPT durationMonths post-percutaneous coronary interventionClopidogrel subgroupRandomized controlled trialsNo significant differenceCoronary syndromeMonotherapyTicagrelor monotherapyDAPT durationShorter DAPTBleedingStent thrombosisP2Y12iMyocardial infarctionControlled trialsSubgroup interactionsDAPTMeta-analysisMachine learning prediction of one-year mortality after percutaneous coronary intervention in acute coronary syndrome patients
Hosseini K, Behnoush A, Khalaji A, Etemadi A, Soleimani H, Pasebani Y, Jenab Y, Masoudkabir F, Tajdini M, Mehrani M, Nanna M. Machine learning prediction of one-year mortality after percutaneous coronary intervention in acute coronary syndrome patients. International Journal Of Cardiology 2024, 409: 132191. PMID: 38777044, DOI: 10.1016/j.ijcard.2024.132191.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionLogistic regressionPost-PCI mortalityPrediction of one-year mortalityCoronary interventionPrediction of 1-year mortalityBody mass indexAcute coronary syndrome patientsOne-year mortalityIndividual-level assessmentsReceiver operating characteristic curveAcute coronary syndromeCoronary syndrome patientsTehran Heart CenterRates of comorbiditiesMass indexHigher ageSyndrome patientsCoronary syndromeHeart CenterFollow-upLipid profileU-shaped correlationPatientsCharacteristic curveDuration of Dual Antiplatelet Therapy After Percutaneous Coronary Intervention in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Network Meta-analysis
Park D, Hu J, Campbell G, Goldwag K, Kelsey M, Altin S, Gallegos-Kattán C, Nanna M. Duration of Dual Antiplatelet Therapy After Percutaneous Coronary Intervention in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Network Meta-analysis. Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 3: 101859. PMID: 39131993, PMCID: PMC11307649, DOI: 10.1016/j.jscai.2024.101859.Peer-Reviewed Original ResearchMonths of DAPTDuration of dual antiplatelet therapyNet adverse clinical eventsType 2 diabetes mellitusDual antiplatelet therapyAcute coronary syndromeRandomized controlled trialsSensitivity analysis of trialsPercutaneous coronary interventionCoronary interventionNo significant differenceAntiplatelet therapyAnalysis of trialsCoronary syndromeControlled trialsMeta-analysis of patientsStent thrombosisMeta-analysisDAPT durationClinicians greater flexibilityStudy-level meta-analysisOptimal duration of dual antiplatelet therapyHigher risk of adverse eventsPostpercutaneous coronary interventionRisk of adverse eventsShorter Dual Antiplatelet Therapy for Older Adults After Percutaneous Coronary Intervention
Park D, Hu J, Jamil Y, Kelsey M, Jones W, Frampton J, Kochar A, Aronow W, Damluji A, Nanna M. Shorter Dual Antiplatelet Therapy for Older Adults After Percutaneous Coronary Intervention. JAMA Network Open 2024, 7: e244000. PMID: 38546647, PMCID: PMC10979312, DOI: 10.1001/jamanetworkopen.2024.4000.Peer-Reviewed Original ResearchConceptsOlder adultsMonths of DAPTDuration of dual antiplatelet therapySystematic reviewRandomized clinical trialsPercutaneous coronary interventionMeta-analysisPreferred Reporting ItemsAssess data qualityRisk of bleedingDuration of DAPTDual antiplatelet therapyWeb of ScienceMain OutcomesReporting ItemsData extractionAbstracted dataSecondary outcomesRisk ratioAntiplatelet therapyPrimary outcomeCochrane LibraryCoronary interventionReference groupNetwork meta-analysis
2023
The association of timing of coronary artery bypass grafting for non-ST-elevation myocardial infarction and clinical outcomes in the contemporary United States
Park D, Singireddy S, Mangalesh S, Fishman E, Ambrosini A, Jamil Y, Vij A, Sikand N, Ahmad Y, Frampton J, Nanna M. The association of timing of coronary artery bypass grafting for non-ST-elevation myocardial infarction and clinical outcomes in the contemporary United States. Coronary Artery Disease 2023, 35: 261-269. PMID: 38164979, PMCID: PMC11042982, DOI: 10.1097/mca.0000000000001314.Peer-Reviewed Original ResearchLength of stayCoronary artery bypassElevation myocardial infarctionNSTEMI hospitalizationsHospital mortalityArtery bypassCABG surgeryMyocardial infarctionHigher oddsLonger LOSBurden of complicationsHospital-associated costsNon-home dischargeAcute kidney injuryHigh-risk featuresPercutaneous coronary interventionAssociation of timingOutcomes of interestNSTEMI populationGastrointestinal hemorrhageHospital outcomesKidney injuryPerioperative complicationsCoronary interventionBlood transfusionTCT-641 Intravascular Imaging-Guided Versus Angiography-Guided Percutaneous Coronary Intervention: A Meta-Analysis of Randomized Trials
Sreenivasan J, Reddy R, Jamil Y, Malik A, Chamie D, Howard J, Nanna M, Mintz G, Maehara A, Ali Z, Moses J, Chen S, Chieffo A, Colombo A, Leon M, Lansky A, Ahmad Y. TCT-641 Intravascular Imaging-Guided Versus Angiography-Guided Percutaneous Coronary Intervention: A Meta-Analysis of Randomized Trials. Journal Of The American College Of Cardiology 2023, 82: b258. DOI: 10.1016/j.jacc.2023.09.652.Peer-Reviewed Original ResearchComplex Percutaneous Coronary Intervention Outcomes in Older Adults
Hanna J, Wang S, Kochar A, Park D, Damluji A, Henry G, Ahmad Y, Curtis J, Nanna M. Complex Percutaneous Coronary Intervention Outcomes in Older Adults. Journal Of The American Heart Association 2023, 12: e029057. PMID: 37776222, PMCID: PMC10727245, DOI: 10.1161/jaha.122.029057.Peer-Reviewed Original ResearchConceptsNoncomplex percutaneous coronary interventionsComplex percutaneous coronary interventionStable ischemic heart diseasePercutaneous coronary interventionIschemic heart diseaseTarget lesion revascularizationEvent-free survivalHeart diseaseOlder adultsCause deathLesion revascularizationClinical characteristicsElective percutaneous coronary interventionPercutaneous coronary intervention outcomesWorse event-free survivalMedical therapy useCox regression modelLarge health systemNoncardiac comorbiditiesRevascularization riskCoronary interventionTherapy useClinical outcomesDisease featuresLower riskTrends and Inhospital Outcomes of Intravascular Imaging on Single-Vessel Coronary Chronic Total Occlusion Treated With Percutaneous Coronary Intervention
Park D, Hu J, Kanitsoraphan C, Al-Ogaili A, Murthi M, Vardar U, Ahmad Y, Nanna M, Vij A. Trends and Inhospital Outcomes of Intravascular Imaging on Single-Vessel Coronary Chronic Total Occlusion Treated With Percutaneous Coronary Intervention. The American Journal Of Cardiology 2023, 206: 79-85. PMID: 37683583, PMCID: PMC10901566, DOI: 10.1016/j.amjcard.2023.08.051.Peer-Reviewed Original ResearchPercutaneous coronary interventionChronic total occlusionInhospital mortalityIntravascular ultrasoundOptical coherence tomographyInhospital outcomesIntravascular imagingCoronary interventionTotal occlusionCTO-PCISingle-vessel chronic total occlusionSingle-vessel percutaneous coronary interventionCoronary chronic total occlusionsUse of IVUSLarge national analysisUse of OCTIVUS useOCT useCoherence tomographyLogistic regressionPatientsAbsolute numberCochran-ArmitageMortalityLess increaseInsight Into the Optimal Timing of Percutaneous Coronary Intervention and Transcatheter Aortic Valve Replacement
Park D, Simonato M, Ahmad Y, Banks A, Lowenstern A, Nanna M. Insight Into the Optimal Timing of Percutaneous Coronary Intervention and Transcatheter Aortic Valve Replacement. Current Problems In Cardiology 2023, 49: 102050. PMID: 37643698, PMCID: PMC10924682, DOI: 10.1016/j.cpcardiol.2023.102050.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementPercutaneous coronary artery interventionAcute kidney injuryAortic valve replacementKidney injuryValve replacementPercutaneous coronary interventionCoronary artery diseaseCoronary artery interventionPaucity of dataHospital mortalityNonhome dischargeCoronary interventionSecondary outcomesSelect patientsArtery diseaseArtery interventionClinical outcomesHigher oddsPCI timingPatientsReadmissionOptimal timingSame daySignificant differencesA Geriatric Approach to Percutaneous Coronary Interventions in Older Adults, Part II A JACC: Advances Expert Panel
Nanna M, Sutton N, Kochar A, Rymer J, Lowenstern A, Gackenbach G, Hummel S, Goyal P, Rich M, Kirkpatrick J, Krishnaswami A, Alexander K, Forman D, Bortnick A, Batchelor W, Damluji A. A Geriatric Approach to Percutaneous Coronary Interventions in Older Adults, Part II A JACC: Advances Expert Panel. JACC Advances 2023, 2: 100421. PMID: 37575202, PMCID: PMC10419335, DOI: 10.1016/j.jacadv.2023.100421.Peer-Reviewed Original ResearchPercutaneous coronary interventionCoronary interventionOlder adultsPreprocedural risk assessmentGoals of carePatient-centered outcomesInterventional cardiology practiceOlder adult populationHeart team membersGeriatric approachOlder patientsHeart teamGeriatric syndromesPharmacotherapeutic considerationsGeriatric specialistsCardiology practiceGeriatric principlesGeriatric risksAdult populationExpert panelAdultsRisk assessmentInterventionFacilitate uptakeCurrent knowledgeComparison of intravascular ultrasound, optical coherence tomography, and conventional angiography‐guided percutaneous coronary interventions: A systematic review, network meta‐analysis, and meta‐regression
Park D, An S, Jolly N, Attanasio S, Yadav N, Gutierrez J, Nanna M, Rao S, Vij A. Comparison of intravascular ultrasound, optical coherence tomography, and conventional angiography‐guided percutaneous coronary interventions: A systematic review, network meta‐analysis, and meta‐regression. Catheterization And Cardiovascular Interventions 2023, 102: 440-450. PMID: 37483068, PMCID: PMC10908343, DOI: 10.1002/ccd.30784.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsPercutaneous coronary interventionOptical coherence tomographyCoronary angiographyIntravascular ultrasoundCoronary interventionCardiac deathClinical outcomesClinical efficacyConventional angiography-guided PCIAngiography-guided percutaneous coronary interventionCoherence tomographyUse of IVUSSuperiority of OCTAdverse cardiovascular eventsRandomized clinical trialsConventional coronary angiographyImaging modalitiesComparative clinical efficacyBest imaging modalityIntracoronary imaging modalityLesion revascularizationPCI guidanceCardiovascular eventsCause mortalityAssessment and Management of Older Adults Undergoing PCI, Part 1 A JACC: Advances Expert Panel
Nanna M, Sutton N, Kochar A, Rymer J, Lowenstern A, Gackenbach G, Hummel S, Goyal P, Rich M, Kirkpatrick J, Krishnaswami A, Alexander K, Forman D, Bortnick A, Batchelor W, Damluji A, Councils A. Assessment and Management of Older Adults Undergoing PCI, Part 1 A JACC: Advances Expert Panel. JACC Advances 2023, 2: 100389. PMID: 37584013, PMCID: PMC10426754, DOI: 10.1016/j.jacadv.2023.100389.Peer-Reviewed Original ResearchHigh-risk percutaneous coronary interventionOlder adultsProportion of patientsPercutaneous coronary interventionHigh-risk groupCardiac catheterization laboratoryConventional risk assessment toolsRisk assessment toolCardiovascular riskCoronary interventionGeriatric syndromesGeriatric domainsCardiovascular SocietyProcedural riskCatheterization laboratoryHemodynamic riskPopulation agesDisproportionate riskExpert panelStructured risk assessmentPatientsRiskAdultsAssessment toolMorbidityDelirium in older adults after percutaneous coronary intervention: Prevalence, risks, and clinical phenotypes
Park D, Jamil Y, Hu J, Lowenstern A, Frampton J, Abdullah A, Damluji A, Ahmad Y, Soufer R, Nanna M. Delirium in older adults after percutaneous coronary intervention: Prevalence, risks, and clinical phenotypes. Cardiovascular Revascularization Medicine 2023, 57: 60-67. PMID: 37414611, PMCID: PMC10730763, DOI: 10.1016/j.carrev.2023.06.010.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionHospital mortalityHigher oddsOlder adultsHospital deliriumCoronary interventionAdverse health-related outcomesInpatient percutaneous coronary interventionNon-home dischargePeri-procedural settingAcute kidney injuryImpact of deliriumPost-procedural complicationsNational Inpatient SampleHealth-related outcomesDelirium preventionHospital complicationsMore comorbiditiesGastrointestinal hemorrhageKidney injuryAdverse eventsSecondary outcomesBlood transfusionPrimary outcomeIntracranial hemorrhageTrends and impact of intravascular ultrasound and optical coherence tomography on percutaneous coronary intervention for myocardial infarction
Park D, Vemmou E, An S, Nikolakopoulos I, Regan C, Cambi B, Frampton J, Vij A, Brilakis E, Nanna M. Trends and impact of intravascular ultrasound and optical coherence tomography on percutaneous coronary intervention for myocardial infarction. IJC Heart & Vasculature 2023, 45: 101186. PMID: 36852085, PMCID: PMC9957744, DOI: 10.1016/j.ijcha.2023.101186.Peer-Reviewed Original ResearchIntravascular imaging-guided percutaneous coronary interventionImaging-guided percutaneous coronary interventionPercutaneous coronary interventionOptical coherence tomographyMyocardial infarctionIntravascular ultrasoundCoronary interventionIntravascular imagingIVUS-guided percutaneous coronary interventionCoherence tomographyNumber of PCIsNational Inpatient SampleMultivariable logistic regressionCochran-Armitage trend testIVUS useHospital mortalityClinical outcomesOCT guidanceInpatient SampleImproved outcomesLower oddsLower mortalityLogistic regressionContinuous outcomesOutcomes
2022
Readmission and adverse outcomes after percutaneous coronary intervention in patients with dementia
Park D, Hu J, Alexander K, Nanna M. Readmission and adverse outcomes after percutaneous coronary intervention in patients with dementia. Journal Of The American Geriatrics Society 2022, 71: 1034-1046. PMID: 36409823, PMCID: PMC10089937, DOI: 10.1111/jgs.18120.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionInhospital adverse eventsKidney injuryAdverse eventsCoronary interventionAdverse outcomesHigher readmission riskMultivariable Cox modelingAcute kidney injuryThirty-day readmissionIschemic heart diseaseCox proportional hazardsLogistic regression modelingDiagnosis of dementiaInhospital mortalityNoncardiac proceduresIndex hospitalizationReadmission ratesCox modelingReadmission riskCardiac arrestHeart diseasePCI experienceHigher oddsReadmissionIn-hospital outcomes and readmission in older adults treated with percutaneous coronary intervention for stable ischemic heart disease
Park DY, Hanna JM, Kadian S, Kadian M, Jones WS, Damluji AA, Kochar A, Curtis JP, Nanna MG. In-hospital outcomes and readmission in older adults treated with percutaneous coronary intervention for stable ischemic heart disease. Journal Of Geriatric Cardiology 2022, 19: 631-642. PMID: 36284680, PMCID: PMC9548058, DOI: 10.11909/j.issn.1671-5411.2022.09.006.Peer-Reviewed Original ResearchStable ischemic heart diseasePercutaneous coronary interventionInpatient percutaneous coronary interventionIschemic heart diseaseHospital mortalityOlder adultsIndex hospitalizationCoronary interventionHospital chargesHeart diseaseNational Readmission DatabaseTotal hospital chargesHigh-risk cohortOlder adult patientsPeriprocedural morbidityCardiovascular causesGastrointestinal hemorrhageHospital lengthHospital outcomesAdult patientsSecondary outcomesLonger LOSPrimary outcomeIntracranial hemorrhageProcedural riskShortening the duration of dual antiplatelet therapy after percutaneous coronary intervention for acute coronary syndrome: A systematic review and meta-analysis
Park DY, Wang P, An S, Grimshaw AA, Frampton J, Ohman EM, Rao SV, Nanna MG. Shortening the duration of dual antiplatelet therapy after percutaneous coronary intervention for acute coronary syndrome: A systematic review and meta-analysis. American Heart Journal 2022, 251: 101-114. PMID: 35654162, PMCID: PMC10904033, DOI: 10.1016/j.ahj.2022.05.019.Peer-Reviewed Original ResearchConceptsMonths of DAPTHazard ratioIschemic eventsDuration of DAPTSelect patient characteristicsDual antiplatelet therapyAcute coronary syndromeCoronary artery lesionsPercutaneous coronary interventionConfidence intervalsAssociation of outcomesRandom-effects modelComprehensive literature searchMeta-regression analysisMajor bleedingAntiplatelet therapyCoronary syndromeArtery lesionsCoronary interventionControlled TrialsPatient characteristicsPrespecified outcomesGreater proportionSimilar efficacySystematic review
2019
A systematic review of randomized trials comparing double versus triple antithrombotic therapy in patients with atrial fibrillation undergoing percutaneous coronary intervention
Sullivan AE, Nanna MG, Rao SV, Cantrell S, Gibson CM, Verheugt FWA, Peterson ED, Lopes RD, Alexander JH, Granger CB, Yee MK, Kong DF. A systematic review of randomized trials comparing double versus triple antithrombotic therapy in patients with atrial fibrillation undergoing percutaneous coronary intervention. Catheterization And Cardiovascular Interventions 2019, 96: e102-e109. PMID: 31713326, PMCID: PMC7211549, DOI: 10.1002/ccd.28535.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAnticoagulantsAtrial FibrillationCoronary ThrombosisDual Anti-Platelet TherapyFemaleFibrinolytic AgentsHemorrhageHumansMalePercutaneous Coronary InterventionPlatelet Aggregation InhibitorsPurinergic P2Y Receptor AntagonistsRandomized Controlled Trials as TopicRisk FactorsTreatment OutcomeConceptsPercutaneous coronary interventionAcute coronary syndromeDouble therapyOral anticoagulationAtrial fibrillationTriple therapyAntithrombotic therapyCoronary syndromeCoronary interventionStent thrombosisMajor adverse cardiovascular eventsTriple antithrombotic therapyAdverse cardiovascular eventsDual antiplatelet therapyOptimal antithrombotic therapyGood safety profileRandom-effects modelIschemic outcomesAntiplatelet therapyCardiovascular eventsP2Y12 inhibitorsMedical managementRandomized trialsIntracranial hemorrhageSafety profileAge, knowledge, preferences, and risk tolerance for invasive cardiac care
Nanna MG, Peterson ED, Wu A, Harding T, Galanos AN, Wruck L, Alexander KP. Age, knowledge, preferences, and risk tolerance for invasive cardiac care. American Heart Journal 2019, 219: 99-108. PMID: 31733450, PMCID: PMC6944066, DOI: 10.1016/j.ahj.2019.09.008.Peer-Reviewed Original ResearchConceptsInvasive cardiac careAcute coronary syndromeInvasive cardiovascular proceduresCardiac careCardiovascular proceduresSingle academic medical centerCoronary artery bypassProspective cohort studyPercutaneous coronary interventionGroup of patientsConfidence intervalsSubstantial inter-individual variabilityAcademic medical centerArtery bypassCABG surgeryCoronary syndromeBaseline characteristicsCohort studyCoronary interventionYounger patientsCardiac catheterizationInvasive careInter-individual variabilityCare teamCardiovascular careSex-Based Differences in Presentation, Treatment, and Complications Among Older Adults Hospitalized for Acute Myocardial Infarction
Nanna MG, Hajduk AM, Krumholz HM, Murphy TE, Dreyer RP, Alexander KP, Geda M, Tsang S, Welty FK, Safdar B, Lakshminarayan DK, Chaudhry SI, Dodson JA. Sex-Based Differences in Presentation, Treatment, and Complications Among Older Adults Hospitalized for Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2019, 12: e005691. PMID: 31607145, PMCID: PMC6913190, DOI: 10.1161/circoutcomes.119.005691.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overComorbidityDisability EvaluationFemaleHealth Status DisparitiesHealthcare DisparitiesHumansLife StyleMaleMyocardial RevascularizationNon-ST Elevated Myocardial InfarctionPatient AdmissionPrevalenceProspective StudiesRisk AssessmentRisk FactorsSex FactorsSocial Determinants of HealthST Elevation Myocardial InfarctionTime FactorsTreatment OutcomeUnited StatesConceptsAcute myocardial infarctionSex-based differencesPercutaneous coronary interventionFunctional impairmentOlder adultsHospital complicationsCoronary interventionOlder patientsCoronary diseaseMyocardial infarctionAge-related functional impairmentsAge-associated functional impairmentsLower ratesPrior coronary diseaseObstructive coronary diseaseProspective observational studyNSTEMI subgroupSTEMI subgroupUnderwent revascularizationAcute myocardialChest painClinical presentationAMI subgroupRisk factorsHigh prevalence