2023
1558-P: The Mitochondrial Calcium Uniporter Regulates Hepatic Mitochondrial Oxidation and Intracellular Redox In Vivo
LAMOIA T, HUBBARD B, GUERRA M, GOODMAN R, NATHANSON M, SHULMAN G. 1558-P: The Mitochondrial Calcium Uniporter Regulates Hepatic Mitochondrial Oxidation and Intracellular Redox In Vivo. Diabetes 2023, 72 DOI: 10.2337/db23-1558-p.Peer-Reviewed Original ResearchNonalcoholic fatty liver diseaseHepatic mitochondrial oxidationMitochondrial calcium uniporterHepatocellular redox stateFatty liver diseaseEctopic lipid accumulationType 2 diabetesHepatic lipid contentNovel therapeutic targetMitochondrial oxidationHepatic triacylglycerol contentMitochondrial calcium influxMitochondrial redox ratioMitochondrial calciumKnockout mouse modelFortress BiotechMitochondrial fat oxidationNonalcoholic steatohepatitisLiver diseaseWT miceKO miceMetabolic dysfunctionCalcium uniporterCalcium influxMouse model
2020
Inositol 1,4,5 trisphosphate receptors in secretory epithelial cells of the gastrointestinal tract
Lemos F, Guerra M, de Fátima Leite M. Inositol 1,4,5 trisphosphate receptors in secretory epithelial cells of the gastrointestinal tract. Current Opinion In Physiology 2020, 17: 169-174. DOI: 10.1016/j.cophys.2020.08.003.Peer-Reviewed Original ResearchEpithelial cellsFatty liver diseaseIntracellular calcium signalingLiver diseaseAcute pancreatitisSecretory epithelial cellsPathophysiological roleGastrointestinal tractElectrolyte secretionSolid tumorsIntracellular Ca2Main intracellular Ca2Number of diseasesDiseaseCell proliferationCalcium signalingEnergy metabolismReceptorsMolecular mechanismsSubcellular localizationTrisphosphate receptorPhysiological functionsCellsInositol 1Ca2Ca2+ Signaling in the Liver
Guerra M, Leite M, Nathanson M. Ca2+ Signaling in the Liver. 2020, 496-508. DOI: 10.1002/9781119436812.ch40.ChaptersBile duct epitheliumDuct epitheliumNon-alcoholic fatty liver diseaseBile acid-independent bile flowBile acid-dependent flowFatty liver diseaseLiver diseaseBile flowElectrolyte secretionLipid metabolismGrowth factorLiverCell populationsRat liverVariety of mechanismsEpitheliumCa2Recent studiesCell cycleHepatocytesLesser extentPathogenesisDiseaseNeurotransmittersHormone