2024
Lung infections due to emerging fungal pathogens
Roman F, Pischel L, Azar M. Lung infections due to emerging fungal pathogens. Current Opinion In Pulmonary Medicine 2024, 30: 258-265. PMID: 38411158, DOI: 10.1097/mcp.0000000000001059.Peer-Reviewed Original ResearchConceptsEndemic mycosesManagement of pulmonary infectionsFungal pathogensPathogenic fungiAntifungal prophylaxisBlastomyces speciesFungal infectionsFungal organismsAspergillus moldsEnvironmental changesImmunocompromised hostsPulmonary infectionTherapeutic challengeLung infectionMycosesClinical evidenceClinical managementIncreased incidencePulmonary diseaseEnlarged poolDisease burdenInfectionLomentosporaScedosporiumDiagnostic capabilities
2023
A Diagnostic Approach to Fungal Pneumonia An Infectious Diseases Perspective
Azar M. A Diagnostic Approach to Fungal Pneumonia An Infectious Diseases Perspective. CHEST Journal 2023, 165: 559-572. PMID: 37813181, DOI: 10.1016/j.chest.2023.10.005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsFungal pneumoniaAppropriate diagnostic testingClinical syndromeDiagnostic testingLower respiratory tract infectionsNon-resolving pneumoniaRespiratory tract infectionsInfectious diseases perspectiveTract infectionsRadiographic patternsCommon causeEpidemiologic exposuresCorrect diagnosisRisk populationsPneumoniaDiagnostic approachHost factorsDisease perspectiveConstellation of factorsPatientsSyndromeInfectionEpidemiologyIncidenceDiagnosis
2022
Real-world assessment of the clinical utility of whole body 18F-FDG PET/CT in the diagnosis of infection.
Medvedeva N, Radcliffe C, Malinis M, Chen M, Azar M. Real-world assessment of the clinical utility of whole body 18F-FDG PET/CT in the diagnosis of infection. PLOS ONE 2022, 17: e0277403. PMID: 36374789, PMCID: PMC9662742, DOI: 10.1371/journal.pone.0277403.Peer-Reviewed Original ResearchConceptsPET/CTClinical impactFDG PET/CTRetrospective chart reviewEmission tomography/Evaluation of infectionDiagnosis of infectionVariety of syndromesInfectious indicationsChart reviewCommon indicationTomography useUnknown etiologyEndovascular infectionTomography/Antimicrobial managementClinical indicationsReal-world assessmentInclusion criteriaClinical utilityPatientsTreatment managementUnknown originInfectionCTMucocutaneous Leishmaniasis in a Pregnant Immigrant
Briggs N, Wei BM, Ahuja C, Baker C, Palacios C, Lee E, O’Grady N, Singanamala S, Singh K, Bandaranayake TD, Cohen JM, Damsky W, Davis MW, Mejia R, Nelson CA, Topal JE, Azar MM. Mucocutaneous Leishmaniasis in a Pregnant Immigrant. Open Forum Infectious Diseases 2022, 9: ofac360. PMID: 35928503, PMCID: PMC9345408, DOI: 10.1093/ofid/ofac360.Peer-Reviewed Original ResearchLaboratory Diagnosis for SARS-CoV-2 Infection
Christensen BB, Azar MM, Turbett SE. Laboratory Diagnosis for SARS-CoV-2 Infection. Infectious Disease Clinics Of North America 2022, 36: 327-347. PMID: 35636903, PMCID: PMC9141924, DOI: 10.1016/j.idc.2022.02.002.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionClinical syndromeMolecular testingPatient's clinical syndromeReverse transcriptase-polymerase chain reactionOptimal diagnostic testCOVID-19 infectionSymptom onsetAcute infectionAntigen testingSerologic testingAcute diagnosisPolymerase chain reactionLaboratory diagnosisDiagnostic testsInfectionChain reactionDiagnosisSyndromeTesting
2021
Transplant Adenovirus Infection: Clinical Syndromes, Diagnosis, and Management
Malinis M, Azar M. Transplant Adenovirus Infection: Clinical Syndromes, Diagnosis, and Management. 2021, 781-805. DOI: 10.1007/978-3-030-25869-6_33.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSolid organ transplant recipientsInadequate clinical responseReduction of immunosuppressionCornerstone of treatmentOrgan transplant recipientsSolid organ transplantationManifestations of diseaseDirect antigen detectionGraft dysfunctionGraft lossImmunosuppression reductionTransplant recipientsClinical responseAntiviral therapySignificant morbidityAsymptomatic sheddingTherapeutic optionsViral cultureClinical syndromeAdenoviral diseaseOrgan transplantationHematopoietic stem cellsAntigen detectionAdenovirus infectionInfectionEmerging Diagnostics for Transplant Infectious Diseases
Azar M, Gaston D, Malinis M. Emerging Diagnostics for Transplant Infectious Diseases. 2021, 1535-1576. DOI: 10.1007/978-3-030-25869-6_69.Peer-Reviewed Original ResearchTransplant infectious diseasesInfectious diseasesPolymerase chain reaction panelHematopoietic stem cell transplantationCommunity-acquired infectionsStem cell transplantationMultidrug-resistant organismsTest performance characteristicsTransplant patientsUncommon pathogenCell transplantationSerious infectionsPatient outcomesClinical impactDiagnostic modalitiesSolid organsMolecular testingClinical specimensPatientsDiseaseDiagnostic advantageInfectionResistance detectionDiagnostic methodsDiagnostic capabilities
2020
Endemic Fungi Presenting as Community-Acquired Pneumonia: A Review
Azar MM, Malo J, Hage CA. Endemic Fungi Presenting as Community-Acquired Pneumonia: A Review. Seminars In Respiratory And Critical Care Medicine 2020, 41: 522-537. PMID: 32629490, DOI: 10.1055/s-0040-1702194.Peer-Reviewed Original ResearchConceptsCommunity-acquired pneumoniaCommon bacterial causeAreas of endemicityDimorphic fungal infectionsRespiratory manifestationsClinical presentationPulmonary histoplasmosisTreatment strategiesDiagnostic modalitiesBacterial causeEndemic areasFungal infectionsPneumoniaHistoplasma capsulatumHistoplasmosisCoccidioides posadasiiBlastomycosisCoccidioidomycosisEpidemiologyDimorphic fungusPresentingReviewPathogenesisInfectionDiagnosisMolecular Testing for Acute Respiratory Tract Infections: Clinical and Diagnostic Recommendations From the IDSA’s Diagnostics Committee
Hanson KE, Azar MM, Banerjee R, Chou A, Colgrove RC, Ginocchio CC, Hayden MK, Holodiny M, Jain S, Koo S, Levy J, Timbrook TT, Caliendo AM. Molecular Testing for Acute Respiratory Tract Infections: Clinical and Diagnostic Recommendations From the IDSA’s Diagnostics Committee. Clinical Infectious Diseases 2020, 71: 2744-2751. PMID: 32369578, PMCID: PMC7454374, DOI: 10.1093/cid/ciaa508.Peer-Reviewed Original ResearchConceptsRespiratory tract infectionsAcute respiratory tract infectionsTract infectionsDiagnostics CommitteeSpecific nucleic acid amplification testsBacterial respiratory tract infectionsNucleic acid amplification testsRoutine clinical practiceDiagnostic reference standardNew molecular testsGlobal health responseClinical signsRespiratory medicineAmplification testsClinical practiceMolecular testingClinical judgmentAvailable assaysHealth responseDiagnostic recommendationsNovel coronavirus pandemicMolecular testsReference standardInfectionMolecular diagnosticsTransplant Adenovirus Infection: Clinical Syndromes, Diagnosis, and Management
Malinis M, Azar M. Transplant Adenovirus Infection: Clinical Syndromes, Diagnosis, and Management. 2020, 1-25. DOI: 10.1007/978-3-030-01751-4_33-1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSolid organ transplant recipientsInadequate clinical responseReduction of immunosuppressionCornerstone of treatmentOrgan transplant recipientsSolid organ transplantationManifestations of diseaseDirect antigen detectionGraft dysfunctionGraft lossImmunosuppression reductionTransplant recipientsClinical responseAntiviral therapySignificant morbidityAsymptomatic sheddingTherapeutic optionsViral cultureClinical syndromeAdenoviral diseaseOrgan transplantationHematopoietic stem cellsAntigen detectionAdenovirus infectionInfectionEmerging Diagnostics for Transplant Infectious Diseases
Azar M, Gaston D, Malinis M. Emerging Diagnostics for Transplant Infectious Diseases. 2020, 1-44. DOI: 10.1007/978-3-030-01751-4_69-1.Peer-Reviewed Original ResearchTransplant infectious diseasesInfectious diseasesPolymerase chain reaction panelHematopoietic stem cell transplantationCommunity-acquired infectionsStem cell transplantationMultidrug-resistant organismsTest performance characteristicsTransplant patientsUncommon pathogenCell transplantationSerious infectionsPatient outcomesClinical impactDiagnostic modalitiesSolid organsMolecular testingClinical specimensPatientsDiseaseDiagnostic advantageInfectionResistance detectionDiagnostic methodsDiagnostic capabilitiesEmerging Microbiology Diagnostics for Transplant Infections: On the Cusp of a Paradigm Shift.
Azar MM, Gaston DC, Kotton CN, Malinis MF. Emerging Microbiology Diagnostics for Transplant Infections: On the Cusp of a Paradigm Shift. Transplantation 2020, 104: 1358-1384. PMID: 31972701, DOI: 10.1097/tp.0000000000003123.BooksConceptsHematopoietic stem cell transplantationInfected transplant recipientsInfectious disease specialistsStem cell transplantationBlood culture specimensArray of pathogensTransplant recipientsTransplant cliniciansClinical outcomesDisease specialistsCell transplantationTransplant infectionsMagnetic resonance-based methodsMicrobiology diagnosticsSolid organsCulture specimensMolecular testingMolecular panelResistance determinantsInfectionOutcomesDiagnostic microbiologyResonance-based methodsPatientsTransplantation
2019
Fungal Immunoepidemiology
Azar M. Fungal Immunoepidemiology. 2019, 179-191. DOI: 10.1007/978-3-030-25553-4_11.Peer-Reviewed Original ResearchFungal infectionsImmune responseImmune defenseHost immune responsePublic health impactImportant fungal infectionsSpecific innateImmunocompetent populationAntifungal vaccinesInvasive mycosesInfectionImmunoepidemiologyFungal recognitionCritical pathwaysHealth impactsDisease susceptibilityAdaptive responseResponseCoccidiomycosisMorbidityPredisposesImmunodeficiencyVaccinePopulationInnate
2017
Donor-Derived Transmission of Candida auris During Lung Transplantation
Azar MM, Turbett SE, Fishman JA, Pierce VM. Donor-Derived Transmission of Candida auris During Lung Transplantation. Clinical Infectious Diseases 2017, 65: 1040-1042. PMID: 28520901, DOI: 10.1093/cid/cix460.Peer-Reviewed Case Reports and Technical NotesConceptsStringent infection control measuresCandida aurisImportant public health implicationsDonor-derived transmissionLung transplant recipientsInfection control measuresPrevention of transmissionPublic health implicationsLung transplantationTransplant recipientsHigh mortalityC. aurisResistant pathogensHealth implicationsTransplantationAurisControl measuresInfectionMortalityRecipientsPrevention
2015
Toscana Virus Encephalitis in a Traveler Returning to the United States
Howell BA, Azar MM, Landry ML, Shaw AC. Toscana Virus Encephalitis in a Traveler Returning to the United States. Journal Of Clinical Microbiology 2015, 53: 1445-1447. PMID: 25673791, PMCID: PMC4365192, DOI: 10.1128/jcm.03498-14.Peer-Reviewed Case Reports and Technical Notes