2013
Identification of posttranslational modified autoantigens in Type 1 diabetes. (P4152)
Yang M, Connolly S, Wen L, Herold K, Mamula M. Identification of posttranslational modified autoantigens in Type 1 diabetes. (P4152). The Journal Of Immunology 2013, 190: 172.3-172.3. DOI: 10.4049/jimmunol.190.supp.172.3.Peer-Reviewed Original ResearchNOD miceType 1 diabetesDiabetes-prone NOD miceEarly-onset diabetic patientsPre-diabetic NOD miceDiabetic NOD miceT cell autoimmunityPathogenesis of T1DPancreatic islet proteinsCell autoimmunityDiabetic patientsImmune toleranceRheumatoid arthritisMultiple sclerosisAutoimmune diseasesMurine modelTarget organsTherapeutic targetSelf proteinsPancreatic isletsIslet proteinsMiceOxidative stressPeripheral erythrocytesDiabetes
2008
Isoaspartyl Posttranslational Modification In Drug‐Induced Lupus
Yang M, Mamula M. Isoaspartyl Posttranslational Modification In Drug‐Induced Lupus. The FASEB Journal 2008, 22: 668.20-668.20. DOI: 10.1096/fasebj.22.1_supplement.668.20.Peer-Reviewed Original ResearchLupus-inducing drugsDrug-induced lupusT cell hyperproliferationMRL miceCell hyperproliferationOnset of autoantibodiesLupus-prone miceProtein L-isoaspartyl methyltransferaseT cell functionDose-dependent mannerERK 1/2 pathwayAutoimmune responseMultiple sclerosisRheumatoid arthritisLymphocyte functionMurine modelSelf proteinsLupusCell functionMiceDrugsHydralazineIntracellular levelsSpontaneous eventsHyperproliferation
2000
Molecular mimicry and the role of B lymphocytes in the processing of autoantigens
Liang B, Mamula* M. Molecular mimicry and the role of B lymphocytes in the processing of autoantigens. Cellular And Molecular Life Sciences 2000, 57: 561-568. PMID: 11130456, PMCID: PMC11147036, DOI: 10.1007/pl00000718.Peer-Reviewed Original ResearchConceptsSelf proteinsB lymphocytesAutoimmune T cell responsesT cell responsesT lymphocyte repertoireAutoreactive cellsSelf antigensAutoimmune diseasesElicit autoimmunityT lymphocytesSelf toleranceSelf peptidesImmune systemMolecular mimicryCell responsesLymphocyte repertoireLymphocytesNormal inhabitantPathogenic agentsInappropriate levelsForeign peptidesMolecular mimicsAutoimmunityAutoantigens