2001
Post-translational protein modifications in antigen recognition and autoimmunity
Doyle H, Mamula M. Post-translational protein modifications in antigen recognition and autoimmunity. Trends In Immunology 2001, 22: 443-449. PMID: 11473834, DOI: 10.1016/s1471-4906(01)01976-7.Peer-Reviewed Original Research
2000
Molecular mimicry and the role of B lymphocytes in the processing of autoantigens
Liang B, Mamula* M. Molecular mimicry and the role of B lymphocytes in the processing of autoantigens. Cellular And Molecular Life Sciences 2000, 57: 561-568. PMID: 11130456, PMCID: PMC11147036, DOI: 10.1007/pl00000718.Peer-Reviewed Original ResearchConceptsSelf proteinsB lymphocytesAutoimmune T cell responsesT cell responsesT lymphocyte repertoireAutoreactive cellsSelf antigensAutoimmune diseasesElicit autoimmunityT lymphocytesSelf toleranceSelf peptidesImmune systemMolecular mimicryCell responsesLymphocyte repertoireLymphocytesNormal inhabitantPathogenic agentsInappropriate levelsForeign peptidesMolecular mimicsAutoimmunityAutoantigens
1999
Isoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins*
Mamula M, Gee R, Elliott J, Sette A, Southwood S, Jones P, Blier P. Isoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins*. Journal Of Biological Chemistry 1999, 274: 22321-22327. PMID: 10428801, DOI: 10.1074/jbc.274.32.22321.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAspartic AcidAutoantibodiesAutoimmunityBinding, CompetitiveB-LymphocytesCytochrome c GroupHistocompatibility Antigens Class IIImmune ToleranceIsomerismLymphocyte ActivationMiceMice, Inbred MRL lprMolecular Sequence DataNuclear Magnetic Resonance, BiomolecularPeptide FragmentsProtein BindingProtein Processing, Post-TranslationalRibonucleoproteins, Small NuclearT-LymphocytesConceptsSystemic lupus erythematosusAutoimmune responseT cell autoimmune responsesHuman systemic lupus erythematosusInitiation of autoimmunityT cell compartmentT cell responsesImmunization of miceFunctioning immune systemLupus erythematosusSelf antigensAutoimmune diseasesImmunologic stimuliC-peptidePeptide autoantigensImmune systemCell responsesForeign pathogensImmunizationCytochrome c peptideMiceCell compartmentPresent studyPeptidesResponseT Cell Autoimmunity in Lupus
Mamula M. T Cell Autoimmunity in Lupus. Contemporary Immunology 1999, 202-219. DOI: 10.1007/978-1-59259-703-1_13.Peer-Reviewed Original ResearchSelf antigensLupus autoimmunityImmune systemSpecific immunologic defectsT cell autoimmunityActivation of lymphocytesComponents of immunityCell autoimmunityAutoimmune syndromeImmunologic defectsAutoimmune diseasesPathologic outcomesProne miceUnmanipulated miceForeign antigensT lymphocytesConventional immunizationAutoimmunitySelf tissuesUncommon occurrenceForeign pathogensObvious malfunctionAntigenAberrant responsesExperimental model
1998
Epitope spreading: the role of self peptides and autoantigen processing by B lymphocytes
Mamula M, Mamula M. Epitope spreading: the role of self peptides and autoantigen processing by B lymphocytes. Immunological Reviews 1998, 164: 231-233. PMID: 9795779, DOI: 10.1111/j.1600-065x.1998.tb01223.x.Peer-Reviewed Original ResearchConceptsImmune responseB lymphocytesAutoantigen-presenting cellsProductive immune responseDiverse immune responsesAutoantigen processingAutoimmune diseasesSelf antigensImmune attackSelf constituentsAntigen leadSelf peptidesViral infectionInfectious agentsImmune systemSelf tissuesAntigenPotential roleAutoimmunityLymphocytesEpitopesConcept of epitopeCellsAgentsInfection
1997
B Lymphocytes as Autoantigen‐presenting Cells in the Amplification of Autoimmunitya
ROTH R, GEE R, MAMULA M. B Lymphocytes as Autoantigen‐presenting Cells in the Amplification of Autoimmunitya. Annals Of The New York Academy Of Sciences 1997, 815: 88-100. PMID: 9186642, DOI: 10.1111/j.1749-6632.1997.tb52047.x.Peer-Reviewed Original ResearchConceptsB cell-deficient miceCell-deficient miceNaive T cellsT cellsSelf antigensIL-4IL-5B cellsB7-2 costimulatory moleculesAutoantigen-presenting cellsAutoreactive T cellsT cell toleranceAntigen-presenting cellsCytokine mRNA responsesB cell subsetsNaive lymphAutoimmune responseCell subsetsCostimulatory moleculesAntigen presentationCytokine mRNAIFN-gammaB lymphocytesCell toleranceMRNA response