2021
Gene expression signatures of target tissues in type 1 diabetes, lupus erythematosus, multiple sclerosis, and rheumatoid arthritis
Szymczak F, Colli M, Mamula M, Evans-Molina C, Eizirik D. Gene expression signatures of target tissues in type 1 diabetes, lupus erythematosus, multiple sclerosis, and rheumatoid arthritis. Science Advances 2021, 7: eabd7600. PMID: 33523973, PMCID: PMC7787485, DOI: 10.1126/sciadv.abd7600.Peer-Reviewed Original ResearchConceptsType 1 diabetesLupus erythematosusTarget tissuesRheumatoid arthritisMultiple sclerosisAutoimmune diseasesImmune systemSystemic lupus erythematosusTarget tissue levelRepurposing of drugsDisease-specific signaturesGene expression signaturesImmune assaultSimilar molecular signaturesClinical useTissue levelsDiseaseHigh expressionExpression signaturesDifferent diseasesErythematosusArthritisSclerosisDiabetesTherapy
2014
Isoaspartyl modification of ZAP70 signaling molecule alters T cell responses (555.9)
Yang M, Clarke S, Mamula M. Isoaspartyl modification of ZAP70 signaling molecule alters T cell responses (555.9). The FASEB Journal 2014, 28 DOI: 10.1096/fasebj.28.1_supplement.555.9.Peer-Reviewed Original ResearchSystemic lupus erythematosusT cell responsesCell responsesT cell immune responsesCell immune responsesAutoreactive immune cellsT cell defectsMajor target organT-cell immunodeficiencyT cell hyperproliferationPIMT-deficient miceProtein L-isoaspartyl methyltransferaseLupus pathologyAutoimmune miceLupus erythematosusImmune toleranceImmune cellsDeficient miceCell immunodeficiencyImmune responseTarget organsT cell signalingImmune systemAutoimmune BCell hyperproliferation
2001
From T to B and back again: positive feedback in systemic autoimmune disease
Shlomchik M, Craft J, Mamula M. From T to B and back again: positive feedback in systemic autoimmune disease. Nature Reviews Immunology 2001, 1: 147-153. PMID: 11905822, DOI: 10.1038/35100573.Peer-Reviewed Original ResearchConceptsSystemic autoimmune diseaseAutoimmune diseasesPrototypical systemic autoimmune diseaseSystemic lupus erythematosusPerpetuation of autoimmunityLoss of toleranceAutoantigen targetsLupus erythematosusAutoimmune stateB cellsImmune systemNuclear autoantigensDiseaseErythematosusAutoimmunityAutoantigensPost-translational protein modifications in antigen recognition and autoimmunity
Doyle H, Mamula M. Post-translational protein modifications in antigen recognition and autoimmunity. Trends In Immunology 2001, 22: 443-449. PMID: 11473834, DOI: 10.1016/s1471-4906(01)01976-7.Peer-Reviewed Original ResearchLupus autoantigens: Their origins, forms, and presentation
Doyle H, Yan J, Liang B, Mamula M. Lupus autoantigens: Their origins, forms, and presentation. Immunologic Research 2001, 24: 131-147. PMID: 11594452, DOI: 10.1385/ir:24:2:131.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusMaintenance of autoimmunityT cell compartmentCentral lymphoid organsT cell developmentAutoimmune processLupus erythematosusAntigenic sinAutoreactive cellsAutoimmune diseasesLymphoid organsPresenting cellsB lymphocytesImmune systemAutoimmunityCell compartmentNumber of mechanismsCell developmentInductionErythematosusCellsLupusForeign proteinsLymphocytesCostimulation
2000
Molecular mimicry and the role of B lymphocytes in the processing of autoantigens
Liang B, Mamula* M. Molecular mimicry and the role of B lymphocytes in the processing of autoantigens. Cellular And Molecular Life Sciences 2000, 57: 561-568. PMID: 11130456, PMCID: PMC11147036, DOI: 10.1007/pl00000718.Peer-Reviewed Original ResearchConceptsSelf proteinsB lymphocytesAutoimmune T cell responsesT cell responsesT lymphocyte repertoireAutoreactive cellsSelf antigensAutoimmune diseasesElicit autoimmunityT lymphocytesSelf toleranceSelf peptidesImmune systemMolecular mimicryCell responsesLymphocyte repertoireLymphocytesNormal inhabitantPathogenic agentsInappropriate levelsForeign peptidesMolecular mimicsAutoimmunityAutoantigens
1999
Isoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins*
Mamula M, Gee R, Elliott J, Sette A, Southwood S, Jones P, Blier P. Isoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins*. Journal Of Biological Chemistry 1999, 274: 22321-22327. PMID: 10428801, DOI: 10.1074/jbc.274.32.22321.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAspartic AcidAutoantibodiesAutoimmunityBinding, CompetitiveB-LymphocytesCytochrome c GroupHistocompatibility Antigens Class IIImmune ToleranceIsomerismLymphocyte ActivationMiceMice, Inbred MRL lprMolecular Sequence DataNuclear Magnetic Resonance, BiomolecularPeptide FragmentsProtein BindingProtein Processing, Post-TranslationalRibonucleoproteins, Small NuclearT-LymphocytesConceptsSystemic lupus erythematosusAutoimmune responseT cell autoimmune responsesHuman systemic lupus erythematosusInitiation of autoimmunityT cell compartmentT cell responsesImmunization of miceFunctioning immune systemLupus erythematosusSelf antigensAutoimmune diseasesImmunologic stimuliC-peptidePeptide autoantigensImmune systemCell responsesForeign pathogensImmunizationCytochrome c peptideMiceCell compartmentPresent studyPeptidesResponseT Cell Autoimmunity in Lupus
Mamula M. T Cell Autoimmunity in Lupus. Contemporary Immunology 1999, 202-219. DOI: 10.1007/978-1-59259-703-1_13.Peer-Reviewed Original ResearchSelf antigensLupus autoimmunityImmune systemSpecific immunologic defectsT cell autoimmunityActivation of lymphocytesComponents of immunityCell autoimmunityAutoimmune syndromeImmunologic defectsAutoimmune diseasesPathologic outcomesProne miceUnmanipulated miceForeign antigensT lymphocytesConventional immunizationAutoimmunitySelf tissuesUncommon occurrenceForeign pathogensObvious malfunctionAntigenAberrant responsesExperimental model
1998
Epitope spreading: the role of self peptides and autoantigen processing by B lymphocytes
Mamula M, Mamula M. Epitope spreading: the role of self peptides and autoantigen processing by B lymphocytes. Immunological Reviews 1998, 164: 231-233. PMID: 9795779, DOI: 10.1111/j.1600-065x.1998.tb01223.x.Peer-Reviewed Original ResearchConceptsImmune responseB lymphocytesAutoantigen-presenting cellsProductive immune responseDiverse immune responsesAutoantigen processingAutoimmune diseasesSelf antigensImmune attackSelf constituentsAntigen leadSelf peptidesViral infectionInfectious agentsImmune systemSelf tissuesAntigenPotential roleAutoimmunityLymphocytesEpitopesConcept of epitopeCellsAgentsInfection
1993
The inability to process a self-peptide allows autoreactive T cells to escape tolerance.
Mamula M. The inability to process a self-peptide allows autoreactive T cells to escape tolerance. Journal Of Experimental Medicine 1993, 177: 567-571. PMID: 8381158, PMCID: PMC2190887, DOI: 10.1084/jem.177.2.567.Peer-Reviewed Original Research