1997
B Lymphocytes as Autoantigen‐presenting Cells in the Amplification of Autoimmunitya
ROTH R, GEE R, MAMULA M. B Lymphocytes as Autoantigen‐presenting Cells in the Amplification of Autoimmunitya. Annals Of The New York Academy Of Sciences 1997, 815: 88-100. PMID: 9186642, DOI: 10.1111/j.1749-6632.1997.tb52047.x.Peer-Reviewed Original ResearchConceptsB cell-deficient miceCell-deficient miceNaive T cellsT cellsSelf antigensIL-4IL-5B cellsB7-2 costimulatory moleculesAutoantigen-presenting cellsAutoreactive T cellsT cell toleranceAntigen-presenting cellsCytokine mRNA responsesB cell subsetsNaive lymphAutoimmune responseCell subsetsCostimulatory moleculesAntigen presentationCytokine mRNAIFN-gammaB lymphocytesCell toleranceMRNA response
1992
Breaking T cell tolerance with foreign and self co-immunogens. A study of autoimmune B and T cell epitopes of cytochrome c.
Mamula M, Lin R, Janeway C, Hardin J. Breaking T cell tolerance with foreign and self co-immunogens. A study of autoimmune B and T cell epitopes of cytochrome c. The Journal Of Immunology 1992, 149: 789-95. PMID: 1321851, DOI: 10.4049/jimmunol.149.3.789.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAutoantigensAutoimmunityB-LymphocytesCross ReactionsCytochrome c GroupGene Rearrangement, beta-Chain T-Cell Antigen ReceptorHumansImmune ToleranceLymphocyte ActivationMiceMice, Inbred StrainsRatsReceptors, Antigen, T-Cell, alpha-betaSequence AlignmentSpecies SpecificityT-LymphocytesConceptsT cell responsesT cell toleranceB cellsCell responsesCell toleranceSelf-AgAutoimmune T cell responsesAutoreactive T cell responsesAutoreactive T cell clonesTCR genesAutoimmune B cellsCellular immune responsesImmune B cellsAutoreactive B cellsT cell clonesT cell epitopesAmino acids 54Autoimmune diseasesT cellsImmune responseCell epitopesForeign pathogensModel autoantigenImmunizationCell clones