2022
Three Times Weekly Dosing of Daprodustat versus Conventional Epoetin for Treatment of Anemia in Hemodialysis Patients
Coyne DW, Singh AK, Lopes RD, Bailey CK, DiMino TL, Huang C, Connaire J, Rastogi A, Kim SG, Orias M, Shah S, Patel V, Cobitz AR, Wanner C. Three Times Weekly Dosing of Daprodustat versus Conventional Epoetin for Treatment of Anemia in Hemodialysis Patients. Clinical Journal Of The American Society Of Nephrology 2022, 17: 1325-1336. PMID: 35918106, PMCID: PMC9625096, DOI: 10.2215/cjn.00550122.Peer-Reviewed Original ResearchConceptsErythropoiesis-stimulating agentsTimes weekly dosingTRIAL REGISTRY NAMESecondary end pointsTreatment of anemiaEpoetin groupDaprodustat groupEnd pointWeekly dosingREGISTRY NAMEHemoglobin valuesMean changeHypoxia-inducible factor prolyl hydroxylase inhibitorCLINICAL TRIAL REGISTRY NAMEPrincipal secondary end pointTreatment-emergent adverse eventsIntravenous iron doseIntravenous iron usePrimary end pointChronic kidney diseaseMean hemoglobin valuesEvaluation periodProlyl hydroxylase inhibitorBaseline hemoglobinPrevalent hemodialysis
2020
Global Dialysis Perspective: Argentina.
Orias M, Rosa Diez GJ. Global Dialysis Perspective: Argentina. Kidney360 2020, 1: 676-679. PMID: 35372938, PMCID: PMC8815540, DOI: 10.34067/kid.0001222019.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2012
Uremic pruritus in hemodialysis patients: treatment with desloratidine versus gabapentin
Marquez D, Ramonda C, Lauxmann JE, Romero CA, Vukelic VL, Martinatto C, Barrón B, Novoa PA, Peixoto AJ, Orías M. Uremic pruritus in hemodialysis patients: treatment with desloratidine versus gabapentin. Brazilian Journal Of Nephrology 2012, 34: 148-152. PMID: 22850916, DOI: 10.1590/s0101-28002012000200007.Peer-Reviewed Original ResearchConceptsUremic pruritusPruritus scoreOne-week washout periodOne-week runAlternate regimenChronic hemodialysisPrimary endpointExcessive sedationVAS scoresDialysis patientsHemodialysis patientsWashout periodMarginal efficacyClinical trialsPruritusSignificant reliefEffective treatmentNineteen subjectsSide effectsGabapentinPatientsMore weeksDesloratadineStatistical significanceTreatment
2011
Preemptive Kidney Transplantation: Experience in Two Centers
Rigo DH, Ziraldo L, Di Monte L, Jimenez MP, Giotto AP, Gutierrez L, Rodriguez I, Orias M, Novoa PA. Preemptive Kidney Transplantation: Experience in Two Centers. Transplantation Proceedings 2011, 43: 3355-3358. PMID: 22099795, DOI: 10.1016/j.transproceed.2011.09.083.Peer-Reviewed Original ResearchConceptsPreemptive kidney transplantEnd-stage renal diseaseDelayed graft functionSubclinical rejectionKidney transplantDeceased donorsInterstitial fibrosis/tubular atrophyDeceased donor groupChronic allograft nephropathyPreemptive kidney transplantationRenal replacement therapyDonor kidney transplantsLong-term dialysisQuality of lifeAllograft nephropathyGraft functionKidney transplantationPreemptive transplantationMonths posttransplantationSerum creatinineTransplantation centersRenal diseaseTubular atrophyCalcineurin inhibitorsPoor outcomeCan aluminum‐based binders be used safely?
Jimenez PM, Douthat W, Orías M. Can aluminum‐based binders be used safely? Seminars In Dialysis 2011, 24: 430-431. PMID: 21801208, DOI: 10.1111/j.1525-139x.2011.00889.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2000
Reproducibility of ambulatory blood pressure monitoring in hemodialysis patients
Peixoto A, Santos S, Mendes R, Crowley S, Maldonado R, Orias M, Mansoor G, White W. Reproducibility of ambulatory blood pressure monitoring in hemodialysis patients. American Journal Of Kidney Diseases 2000, 36: 983-990. PMID: 11054355, DOI: 10.1053/ajkd.2000.19100.Peer-Reviewed Original ResearchConceptsAmbulatory blood pressure monitoringInterdialytic ambulatory blood pressure monitoringBlood pressure monitoringPost-HD valuesHD patientsPressure monitoringReproducibility of ABPMDrug regimenHemodialysis patientsHemodialysis practiceHD sessionNocturnal declineInterdialytic periodPatientsBP determinationRegimenPeriodSleepCoefficient of variation
1999
Extreme Hyperphosphatemia and Acute Renal Failure after a Phosphorus-Containing Bowel Regimen
Orias M, Mahnensmith R, Perazella M. Extreme Hyperphosphatemia and Acute Renal Failure after a Phosphorus-Containing Bowel Regimen. American Journal Of Nephrology 1999, 19: 60-63. PMID: 10085452, DOI: 10.1159/000013427.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsAcute Kidney InjuryAdministration, OralAgedCatharticsHumansMalePhosphatesRenal DialysisConceptsAcute renal failureRenal failureOliguric acute renal failureBowel-cleansing preparationsBowel-cleansing regimenBowel regimenExtreme hyperphosphatemiaHypocalcemic tetanyGastrointestinal proceduresRenal excretionGastrointestinal transitPatientsIntoxicationRegimenFailureHyperphosphatemiaRegimensExcretionDiseaseTetany