2022
Three Times Weekly Dosing of Daprodustat versus Conventional Epoetin for Treatment of Anemia in Hemodialysis Patients
Coyne DW, Singh AK, Lopes RD, Bailey CK, DiMino TL, Huang C, Connaire J, Rastogi A, Kim SG, Orias M, Shah S, Patel V, Cobitz AR, Wanner C. Three Times Weekly Dosing of Daprodustat versus Conventional Epoetin for Treatment of Anemia in Hemodialysis Patients. Clinical Journal Of The American Society Of Nephrology 2022, 17: 1325-1336. PMID: 35918106, PMCID: PMC9625096, DOI: 10.2215/cjn.00550122.Peer-Reviewed Original ResearchMeSH KeywordsAnemiaDouble-Blind MethodEpoetin AlfaErythropoietinHematinicsHemoglobinsHumansIronProlyl-Hydroxylase InhibitorsRecombinant ProteinsRenal DialysisRenal Insufficiency, ChronicTreatment OutcomeConceptsErythropoiesis-stimulating agentsTimes weekly dosingTRIAL REGISTRY NAMESecondary end pointsTreatment of anemiaEpoetin groupDaprodustat groupEnd pointWeekly dosingREGISTRY NAMEHemoglobin valuesMean changeHypoxia-inducible factor prolyl hydroxylase inhibitorCLINICAL TRIAL REGISTRY NAMEPrincipal secondary end pointTreatment-emergent adverse eventsIntravenous iron doseIntravenous iron usePrimary end pointChronic kidney diseaseMean hemoglobin valuesEvaluation periodProlyl hydroxylase inhibitorBaseline hemoglobinPrevalent hemodialysis
2014
Estimated GFR or Albuminuria: Which One Is Really Associated With Resistant Hypertension?
Romero CA, Peixoto AJ, Orias M. Estimated GFR or Albuminuria: Which One Is Really Associated With Resistant Hypertension? Seminars In Nephrology 2014, 34: 492-497. PMID: 25416657, DOI: 10.1016/j.semnephrol.2014.08.002.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAlbuminuriaCoronary VasospasmDrug ResistanceEndothelium, VascularGlomerular Filtration RateHumansHypertensionRenal Insufficiency, ChronicConceptsLow estimated glomerular filtration rateEstimated glomerular filtration rateResistant hypertensionGlomerular filtration rateFiltration rateHigh cardiovascular risk groupTarget organ damageComplications of hypertensionCardiovascular risk groupsHigher sympathetic activityEndothelial dysfunctionFluid overloadSympathetic activityOrgan damageKidney diseaseRisk groupsHigh prevalenceHypertensionMicroalbuminuriaPrevalenceDifferent phenotypesPhenotypeAlbuminuriaComplicationsGFR
2013
Does Kidney Disease Cause Hypertension?
Peixoto AJ, Orias M, Desir GV. Does Kidney Disease Cause Hypertension? Current Hypertension Reports 2013, 15: 89-94. PMID: 23344662, DOI: 10.1007/s11906-013-0327-6.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsGlomerular Filtration RateHumansHypertensionHypertension, RenalKidneyRenal Insufficiency, ChronicConceptsChronic kidney diseaseKidney diseaseRenal functionStructural kidney diseaseGlomerular filtration ratePlasmin-mediated activationExtracellular fluid volumeProteinuric glomerular diseasesPolycystic kidney diseaseChronic hypertensionHypertension increasesEpithelial sodium channelSodium retentionFiltration rateGlomerular diseaseHypertensionCurrent evidenceDiseaseSodium channelsFluid volumeDetectable changeSevere reductionMost casesProteinuriaPatients