2022
Bedtime dosing of antihypertensive medications: systematic review and consensus statement: International Society of Hypertension position paper endorsed by World Hypertension League and European Society of Hypertension
Stergiou G, Brunström M, MacDonald T, Kyriakoulis KG, Bursztyn M, Khan N, Bakris G, Kollias A, Menti A, Muntner P, Orias M, Poulter N, Shimbo D, Williams B, Adeoye AM, Damasceno A, Korostovtseva L, Li Y, Muxfeldt E, Zhang Y, Mancia G, Kreutz R, Tomaszewski M. Bedtime dosing of antihypertensive medications: systematic review and consensus statement: International Society of Hypertension position paper endorsed by World Hypertension League and European Society of Hypertension. Journal Of Hypertension 2022, 40: 1847-1858. PMID: 35983870, DOI: 10.1097/hjh.0000000000003240.Peer-Reviewed Original ResearchConceptsAntihypertensive drugsAntihypertensive medicationsBedtime dosingOutcome trialsDrug dosingClinical practiceEfficient medical interventionsHypertension position paperMorning BP surgeNight-time hypertensionAntihypertensive drug therapyAntihypertensive drug treatmentSingle morning doseBlood pressure profileEffective treatment strategiesWorld Hypertension LeagueInternational SocietyAntihypertensive treatmentBedtime administrationBP controlBP surgeMorning doseMorning dosingCardiovascular eventsAdverse prognosis
2021
Is Isolated Diastolic Hypertension an Important Phenotype?
Romero CA, Tabares AH, Orias M. Is Isolated Diastolic Hypertension an Important Phenotype? Current Cardiology Reports 2021, 23: 177. PMID: 34657205, PMCID: PMC8753786, DOI: 10.1007/s11886-021-01609-w.Peer-Reviewed Original ResearchConceptsNarrow pulse pressureDiastolic hypertensionCardiovascular riskPulse pressureLong-term cardiovascular riskRecent FindingsRecent guidelinesHypertension subgroupIDH definitionsIDH prevalenceHypertensive patientsYounger patientsRisk stratificationEpidemiological characteristicsTherapeutic decisionsPharmacological interventionsHypertension phenotypesCutoff levelHypertensionImportant subgroupPatientsPathophysiologyRiskSubgroupsIDHLong term
2020
Hypertension and kidney disease progression.
Rigo D, Orias M. Hypertension and kidney disease progression. Clinical Nephrology 2020, 93: 103-107. PMID: 31549630, DOI: 10.5414/cnp92s118.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsApolipoprotein L1Blood PressureDisease ProgressionHumansHypertensionHypertension, RenalKidneyNephritisSclerosisConceptsChronic kidney diseaseKidney disease progressionDisease progressionCases of CKDHypertension-attributed nephropathyRisk of progressionAfrican American patientsGene risk variantsClinical suspicionHypertensive nephropathyKidney diseaseUnknown etiologyCommon findingProgressionHypertensionNephropathyPatientsRisk variantsGenetic backgroundEtiologyDiseaseDiagnosisSuspicion
2016
High Blood Pressure 2016: Why Prevention and Control Are Urgent and Important. The World Hypertension League, International Society of Hypertension, World Stroke Organization, International Diabetes Foundation, International Council of Cardiovascular Prevention and Rehabilitation, International Society of Nephrology
Campbell NR, Khalsa T, Executive: W, Lackland DT, Niebylski ML, Nilsson PM, Redburn KA, Orias M, Zhang X, Executive: I, Burrell L, Horiuchi M, Poulter NR, Prabhakaran D, Ramirez AJ, Schiffrin EL, Touyz RM, Wang J, Weber MA, Organization W, Federation I, Prevention and Rehabilitation I, Society of Nephrology I. High Blood Pressure 2016: Why Prevention and Control Are Urgent and Important. The World Hypertension League, International Society of Hypertension, World Stroke Organization, International Diabetes Foundation, International Council of Cardiovascular Prevention and Rehabilitation, International Society of Nephrology. Journal Of Clinical Hypertension 2016, 18: 714-717. PMID: 27316336, PMCID: PMC8031792, DOI: 10.1111/jch.12840.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2010
Hypothesis: It Is Time to Reconsider Phenotypes in Hypertension
Orias M, Tabares AH, Peixoto AJ. Hypothesis: It Is Time to Reconsider Phenotypes in Hypertension. Journal Of Clinical Hypertension 2010, 12: 350-356. PMID: 20546376, PMCID: PMC8673086, DOI: 10.1111/j.1751-7176.2010.00266.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAge FactorsBlood PressureFemaleHemodynamicsHumansHypertensionMaleMyocardial ContractionPhenotypeYoung Adult
2007
Association of ACE genotype and predominantly diastolic hypertension: a preliminary study
Jiménez PM, Conde C, Casanegra A, Romero C, Hugo Tabares A, Orías M. Association of ACE genotype and predominantly diastolic hypertension: a preliminary study. Journal Of The Renin-Angiotensin-Aldosterone System 2007, 8: 42-44. PMID: 17487825, DOI: 10.3317/jraas.2007.006.Peer-Reviewed Original ResearchConceptsPDH patientsDiastolic hypertensionBlood pressureGenotype distributionACE I/D polymorphismAngiotensin-converting enzyme polymorphismACE genotype DDAngiotensin II activityNormotensive control individualsCardiovascular risk factorsHigher plasma ACE levelsSystolic blood pressurePlasma ACE levelsChi-square testMmHg systolicEssential hypertensionPeripheral resistanceNormotensive controlsACE genotypeACE levelsRisk factorsDD genotypeD polymorphismHypertensionPatients
2000
Reproducibility of ambulatory blood pressure monitoring in hemodialysis patients
Peixoto A, Santos S, Mendes R, Crowley S, Maldonado R, Orias M, Mansoor G, White W. Reproducibility of ambulatory blood pressure monitoring in hemodialysis patients. American Journal Of Kidney Diseases 2000, 36: 983-990. PMID: 11054355, DOI: 10.1053/ajkd.2000.19100.Peer-Reviewed Original ResearchConceptsAmbulatory blood pressure monitoringInterdialytic ambulatory blood pressure monitoringBlood pressure monitoringPost-HD valuesHD patientsPressure monitoringReproducibility of ABPMDrug regimenHemodialysis patientsHemodialysis practiceHD sessionNocturnal declineInterdialytic periodPatientsBP determinationRegimenPeriodSleepCoefficient of variation
1998
Blood pressure regulation by potassium channels.
Orias M. Blood pressure regulation by potassium channels. Medicina 1998, 58: 429-32. PMID: 9816709.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPotassium channelsK-ATP channel openerVascular smooth muscle contractionBlood pressure regulationVessel smooth muscleSmooth muscle contractionIntracellular calcium levelsEssential hypertensionHypoxic vasodilatationChannel openersExcessive activationSmooth muscleCalcium levelsPressure regulationMuscle contractionMembrane potentialHypertensionVasodilatationDiazoxidePathogenesisMinoxidil