2012
Uremic pruritus in hemodialysis patients: treatment with desloratidine versus gabapentin
Marquez D, Ramonda C, Lauxmann JE, Romero CA, Vukelic VL, Martinatto C, Barrón B, Novoa PA, Peixoto AJ, Orías M. Uremic pruritus in hemodialysis patients: treatment with desloratidine versus gabapentin. Brazilian Journal Of Nephrology 2012, 34: 148-152. PMID: 22850916, DOI: 10.1590/s0101-28002012000200007.Peer-Reviewed Original ResearchConceptsUremic pruritusPruritus scoreOne-week washout periodOne-week runAlternate regimenChronic hemodialysisPrimary endpointExcessive sedationVAS scoresDialysis patientsHemodialysis patientsWashout periodMarginal efficacyClinical trialsPruritusSignificant reliefEffective treatmentNineteen subjectsSide effectsGabapentinPatientsMore weeksDesloratadineStatistical significanceTreatment
2009
Aliskiren and the Kidney: Beyond Hypertension
Trimarchi H, Orías M. Aliskiren and the Kidney: Beyond Hypertension. Nephrology Research & Reviews 2009, 1: 1-4. DOI: 10.4081/nr.2009.e1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPlasma renin activityRenin activityReceptor blockersGlomerular diseaseRenin angiotensin aldosterone systemAldosterone receptor blockersEndstage kidney diseaseAngiotensin aldosterone systemAngiotensin receptor blockersRenal disease progressionSecondary glomerular diseasesUse of angiotensinRenin-angiotensin systemUrinary protein excretionNew therapeutic optionsDiabetic nephropathyProtein excretionKidney diseaseTherapeutic optionsDisease progressionComplete blockadeUrinary proteinSide effectsEnzyme inhibitorsImportant cause