2021
Is Isolated Diastolic Hypertension an Important Phenotype?
Romero CA, Tabares AH, Orias M. Is Isolated Diastolic Hypertension an Important Phenotype? Current Cardiology Reports 2021, 23: 177. PMID: 34657205, PMCID: PMC8753786, DOI: 10.1007/s11886-021-01609-w.Peer-Reviewed Original ResearchConceptsNarrow pulse pressureDiastolic hypertensionCardiovascular riskPulse pressureLong-term cardiovascular riskRecent FindingsRecent guidelinesHypertension subgroupIDH definitionsIDH prevalenceHypertensive patientsYounger patientsRisk stratificationEpidemiological characteristicsTherapeutic decisionsPharmacological interventionsHypertension phenotypesCutoff levelHypertensionImportant subgroupPatientsPathophysiologyRiskSubgroupsIDHLong termErratum to “Second Consensus on Treatment of Patients Recently Diagnosed with Mild Hypertension and Low Cardiovascular Risk”. [YMCD 45/10 (October 2020) 100653]
Morales-Salinas A, Olsen M, Kones R, Kario K, Wang J, Beilin L, Weber M, Yano Y, Burrell L, Orias M, Dzudie A, Lavie C, Ventura H, Sundström J, de Simone G, Coca A, Rumana U, Marrugat J. Erratum to “Second Consensus on Treatment of Patients Recently Diagnosed with Mild Hypertension and Low Cardiovascular Risk”. [YMCD 45/10 (October 2020) 100653]. Current Problems In Cardiology 2021, 46: 100877. PMID: 34148707, DOI: 10.1016/j.cpcardiol.2021.100877.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2020
Second Consensus on Treatment of Patients Recently Diagnosed With Mild Hypertension and Low Cardiovascular Risk
Morales-Salinas A, Olsen MH, Kones R, Kario K, Wang J, Beilin L, Weber MA, Yano Y, Burrell L, Orias M, Cameroon DA, Lavie CJ, Ventura H, Sundström J, de Simone G, Coca A, Rumana U, Marrugat J. Second Consensus on Treatment of Patients Recently Diagnosed With Mild Hypertension and Low Cardiovascular Risk. Current Problems In Cardiology 2020, 45: 100653. PMID: 32828558, DOI: 10.1016/j.cpcardiol.2020.100653.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsHypertension and kidney disease progression.
Rigo D, Orias M. Hypertension and kidney disease progression. Clinical Nephrology 2020, 93: 103-107. PMID: 31549630, DOI: 10.5414/cnp92s118.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsChronic kidney diseaseKidney disease progressionDisease progressionCases of CKDHypertension-attributed nephropathyRisk of progressionAfrican American patientsGene risk variantsClinical suspicionHypertensive nephropathyKidney diseaseUnknown etiologyCommon findingProgressionHypertensionNephropathyPatientsRisk variantsGenetic backgroundEtiologyDiseaseDiagnosisSuspicion
2014
Electron Microscopy Contribution to Diagnosing Transplant Glomerulopathy: A Single-Center Experience
Rigo D, Barrón MB, Martinatto C, Mukdsi J, Orías M, Novoa P. Electron Microscopy Contribution to Diagnosing Transplant Glomerulopathy: A Single-Center Experience. Transplantation Proceedings 2014, 46: 2975-2980. PMID: 25420804, DOI: 10.1016/j.transproceed.2014.07.008.Peer-Reviewed Original ResearchConceptsInterstitial fibrosis/tubular atrophyDeceased donor renal transplantLower graft survivalPercent of patientsKidney transplant biopsiesSingle-center experienceIdentification of patientsGraft dysfunctionGraft survivalRenal transplantTransplant biopsiesTransplant glomerulopathyGraft pathologyTubular atrophyStudy criteriaHistologic changesPatientsAverage evolution timeEarly changesAccurate diagnosisLight microscopyTransplantation timeBiopsyDiagnosisTransplantation
2013
Does Kidney Disease Cause Hypertension?
Peixoto AJ, Orias M, Desir GV. Does Kidney Disease Cause Hypertension? Current Hypertension Reports 2013, 15: 89-94. PMID: 23344662, DOI: 10.1007/s11906-013-0327-6.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsChronic kidney diseaseKidney diseaseRenal functionStructural kidney diseaseGlomerular filtration ratePlasmin-mediated activationExtracellular fluid volumeProteinuric glomerular diseasesPolycystic kidney diseaseChronic hypertensionHypertension increasesEpithelial sodium channelSodium retentionFiltration rateGlomerular diseaseHypertensionCurrent evidenceDiseaseSodium channelsFluid volumeDetectable changeSevere reductionMost casesProteinuriaPatients
2012
Uremic pruritus in hemodialysis patients: treatment with desloratidine versus gabapentin
Marquez D, Ramonda C, Lauxmann JE, Romero CA, Vukelic VL, Martinatto C, Barrón B, Novoa PA, Peixoto AJ, Orías M. Uremic pruritus in hemodialysis patients: treatment with desloratidine versus gabapentin. Brazilian Journal Of Nephrology 2012, 34: 148-152. PMID: 22850916, DOI: 10.1590/s0101-28002012000200007.Peer-Reviewed Original ResearchConceptsUremic pruritusPruritus scoreOne-week washout periodOne-week runAlternate regimenChronic hemodialysisPrimary endpointExcessive sedationVAS scoresDialysis patientsHemodialysis patientsWashout periodMarginal efficacyClinical trialsPruritusSignificant reliefEffective treatmentNineteen subjectsSide effectsGabapentinPatientsMore weeksDesloratadineStatistical significanceTreatment
2010
Hypothesis: It Is Time to Reconsider Phenotypes in Hypertension
Orias M, Tabares AH, Peixoto AJ. Hypothesis: It Is Time to Reconsider Phenotypes in Hypertension. Journal Of Clinical Hypertension 2010, 12: 350-356. PMID: 20546376, PMCID: PMC8673086, DOI: 10.1111/j.1751-7176.2010.00266.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2009
Is there a role for direct renin inhibitors in chronic kidney disease?
Peixoto AJ, Orias M. Is there a role for direct renin inhibitors in chronic kidney disease? Current Opinion In Nephrology & Hypertension 2009, 18: 397-403. PMID: 19584722, DOI: 10.1097/mnh.0b013e32832e3183.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsChronic kidney diseaseBlood pressure controlKidney disease progressionRenin inhibitorsCardiovascular eventsKidney diseaseDisease progressionEffective blood pressure controlPressure controlHard renal endpointsEarly diabetic nephropathyNormal renal functionDirect renin inhibitorRandomized clinical trialsRenal endpointsStudy drugCardiovascular riskDiabetic nephropathyRenal functionRenal injuryImproved survivalClinical trialsAnimal modelsHuman studiesPatients
2007
Association of ACE genotype and predominantly diastolic hypertension: a preliminary study
Jiménez PM, Conde C, Casanegra A, Romero C, Hugo Tabares A, Orías M. Association of ACE genotype and predominantly diastolic hypertension: a preliminary study. Journal Of The Renin-Angiotensin-Aldosterone System 2007, 8: 42-44. PMID: 17487825, DOI: 10.3317/jraas.2007.006.Peer-Reviewed Original ResearchConceptsPDH patientsDiastolic hypertensionBlood pressureGenotype distributionACE I/D polymorphismAngiotensin-converting enzyme polymorphismACE genotype DDAngiotensin II activityNormotensive control individualsCardiovascular risk factorsHigher plasma ACE levelsSystolic blood pressurePlasma ACE levelsChi-square testMmHg systolicEssential hypertensionPeripheral resistanceNormotensive controlsACE genotypeACE levelsRisk factorsDD genotypeD polymorphismHypertensionPatients
2003
P-118: Association of the DD ACE polymorphism and predominantly diastolic hypertension
Orias M, Jimenez P, Conde C, Tabares A. P-118: Association of the DD ACE polymorphism and predominantly diastolic hypertension. American Journal Of Hypertension 2003, 16: 81a-82a. DOI: 10.1016/s0895-7061(03)00284-x.Peer-Reviewed Original ResearchAmbulatory blood pressure monitoringDiastolic hypertensionACE polymorphismHg diastolic blood pressureAngiotensin II activityNormotensive control individualsCardiovascular risk factorsDiastolic blood pressureBlood pressure monitoringPDH patientsHg systolicHypertensive patientsBlood pressureEssential hypertensionNormotensive controlsPeripheral resistanceACE genotypeRisk factorsDD genotypeHypertensionPressure monitoringPatientsControl individualsGenotype variantsSystolic ratio
2000
Reproducibility of ambulatory blood pressure monitoring in hemodialysis patients
Peixoto A, Santos S, Mendes R, Crowley S, Maldonado R, Orias M, Mansoor G, White W. Reproducibility of ambulatory blood pressure monitoring in hemodialysis patients. American Journal Of Kidney Diseases 2000, 36: 983-990. PMID: 11054355, DOI: 10.1053/ajkd.2000.19100.Peer-Reviewed Original ResearchConceptsAmbulatory blood pressure monitoringInterdialytic ambulatory blood pressure monitoringBlood pressure monitoringPost-HD valuesHD patientsPressure monitoringReproducibility of ABPMDrug regimenHemodialysis patientsHemodialysis practiceHD sessionNocturnal declineInterdialytic periodPatientsBP determinationRegimenPeriodSleepCoefficient of variationC037: Reproducibility of ambulatory blood pressure in hemodialysis patients
Peixoto A, Santos S, Mendes R, Crowley S, Orias M, Maldonado R, Mansoor G, White W. C037: Reproducibility of ambulatory blood pressure in hemodialysis patients. American Journal Of Hypertension 2000, 13: 223a-223a. DOI: 10.1016/s0895-7061(00)00757-3.Peer-Reviewed Original Research
1999
Extreme Hyperphosphatemia and Acute Renal Failure after a Phosphorus-Containing Bowel Regimen
Orias M, Mahnensmith R, Perazella M. Extreme Hyperphosphatemia and Acute Renal Failure after a Phosphorus-Containing Bowel Regimen. American Journal Of Nephrology 1999, 19: 60-63. PMID: 10085452, DOI: 10.1159/000013427.Peer-Reviewed Case Reports and Technical NotesConceptsAcute renal failureRenal failureOliguric acute renal failureBowel-cleansing preparationsBowel-cleansing regimenBowel regimenExtreme hyperphosphatemiaHypocalcemic tetanyGastrointestinal proceduresRenal excretionGastrointestinal transitPatientsIntoxicationRegimenFailureHyperphosphatemiaRegimensExcretionDiseaseTetany