2023
It is strongly recommended to not conduct, fund, or publish research studies that use spot urine samples with estimating equations to assess individuals’ sodium (salt) intake in association with health outcomes: a policy statement of the World Hypertension League, International Society of Hypertension and Resolve to Save Lives
Campbell N, Whelton P, Orias M, Cobb L, Jones E, Garg R, Willliams B, Khan N, Chia Y, Jafar T, Ide N. It is strongly recommended to not conduct, fund, or publish research studies that use spot urine samples with estimating equations to assess individuals’ sodium (salt) intake in association with health outcomes: a policy statement of the World Hypertension League, International Society of Hypertension and Resolve to Save Lives. Journal Of Hypertension 2023, 41: 683-686. PMID: 36723484, PMCID: PMC10090307, DOI: 10.1097/hjh.0000000000003385.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSpot urine samplesSodium intakeIndividual sodium intakeWorld Hypertension LeagueHealth outcomesUrine samplesHealth outcome associationsOutcome associationsInternational SocietyDietary sodiumHealth OrganizationIntakeHypertensionHealth impactsShort durationOutcomesAssociationSubstantial controversyLiterature reviewPolicy statements
2022
Implementación de la Iniciativa HEARTS en Argentina: primeros resultados
Rodriguez G, Rosende A, Prado C, Mariño R, Irazola V, DiPette D, Orias M, Arcila G, Laspiur S. Implementación de la Iniciativa HEARTS en Argentina: primeros resultados. BULL PAN AM HEALTH ORGAN 2022, 46: e181. PMID: 36160765, PMCID: PMC9491484, DOI: 10.26633/rpsp.2022.181.Peer-Reviewed Original ResearchCombination therapyHearts InitiativePrimary health care centersStandardized treatment protocolMain risk factorsHealth care centersCause of mortalityBlood pressure measurement devicesArterial hypertensionRisk factorsCare centerTherapy levelsCardiovascular diseaseHealth centersTreatment protocolHealth teamsBaseline valuesParadoxical decreasePressure measurement deviceClinical competencyPeriod of restrictionHypertensionGeneralized reductionCOVID-19Therapy
2021
Is Isolated Diastolic Hypertension an Important Phenotype?
Romero CA, Tabares AH, Orias M. Is Isolated Diastolic Hypertension an Important Phenotype? Current Cardiology Reports 2021, 23: 177. PMID: 34657205, PMCID: PMC8753786, DOI: 10.1007/s11886-021-01609-w.Peer-Reviewed Original ResearchConceptsNarrow pulse pressureDiastolic hypertensionCardiovascular riskPulse pressureLong-term cardiovascular riskRecent FindingsRecent guidelinesHypertension subgroupIDH definitionsIDH prevalenceHypertensive patientsYounger patientsRisk stratificationEpidemiological characteristicsTherapeutic decisionsPharmacological interventionsHypertension phenotypesCutoff levelHypertensionImportant subgroupPatientsPathophysiologyRiskSubgroupsIDHLong termErratum to “Second Consensus on Treatment of Patients Recently Diagnosed with Mild Hypertension and Low Cardiovascular Risk”. [YMCD 45/10 (October 2020) 100653]
Morales-Salinas A, Olsen M, Kones R, Kario K, Wang J, Beilin L, Weber M, Yano Y, Burrell L, Orias M, Dzudie A, Lavie C, Ventura H, Sundström J, de Simone G, Coca A, Rumana U, Marrugat J. Erratum to “Second Consensus on Treatment of Patients Recently Diagnosed with Mild Hypertension and Low Cardiovascular Risk”. [YMCD 45/10 (October 2020) 100653]. Current Problems In Cardiology 2021, 46: 100877. PMID: 34148707, DOI: 10.1016/j.cpcardiol.2021.100877.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsLlamado a la acción de San Pablo para la prevención y el control de la hipertensión arterial, 2020
Campbell NR, Schutte AE, Varghese CV, Ordunez P, Zhang XH, Khan T, Sharman JE, Whelton PK, Parati G, Weber MA, Orías M, Jaffe MG, Moran AE, Plavnik FL, Ram VS, Brainin M, Owolabi MO, Ramirez AJ, Barbosa E, Bortolotto LA, Lackland DT. Llamado a la acción de San Pablo para la prevención y el control de la hipertensión arterial, 2020. BULL PAN AM HEALTH ORGAN 2021, 45: 1. PMID: 33643404, PMCID: PMC7905751, DOI: 10.26633/rpsp.2021.26.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2020
Standardized treatment to improve hypertension control in primary health care: The HEARTS in the Americas Initiative
DiPette DJ, Goughnour K, Zuniga E, Skeete J, Ridley E, Angell S, Brettler J, Campbell NRC, Coca A, Connell K, Doon R, Jaffe M, Lopez‐Jaramillo P, Moran A, Orias M, Pineiro DJ, Rosende A, González YV, Ordunez P. Standardized treatment to improve hypertension control in primary health care: The HEARTS in the Americas Initiative. Journal Of Clinical Hypertension 2020, 22: 2285-2295. PMID: 33045133, PMCID: PMC8029673, DOI: 10.1111/jch.14072.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAntihypertensive medicationsCardiovascular diseaseTreatment protocolHypertension controlBurden of CVDCVD secondary preventionEffective antihypertensive medicationsMajor hypertension guidelinesRisk factor mitigationControl of hypertensionFixed-dose combinationPrimary health carePost-program implementationCommunity-based programsHypertension guidelinesSecondary preventionBlood pressureCVD burdenInitial treatmentPharmacologic protocolRisk factorsStandardized treatmentMedication formulariesSingle pillHypertensionSecond Consensus on Treatment of Patients Recently Diagnosed With Mild Hypertension and Low Cardiovascular Risk
Morales-Salinas A, Olsen MH, Kones R, Kario K, Wang J, Beilin L, Weber MA, Yano Y, Burrell L, Orias M, Cameroon DA, Lavie CJ, Ventura H, Sundström J, de Simone G, Coca A, Rumana U, Marrugat J. Second Consensus on Treatment of Patients Recently Diagnosed With Mild Hypertension and Low Cardiovascular Risk. Current Problems In Cardiology 2020, 45: 100653. PMID: 32828558, DOI: 10.1016/j.cpcardiol.2020.100653.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsHypertension and kidney disease progression.
Rigo D, Orias M. Hypertension and kidney disease progression. Clinical Nephrology 2020, 93: 103-107. PMID: 31549630, DOI: 10.5414/cnp92s118.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsChronic kidney diseaseKidney disease progressionDisease progressionCases of CKDHypertension-attributed nephropathyRisk of progressionAfrican American patientsGene risk variantsClinical suspicionHypertensive nephropathyKidney diseaseUnknown etiologyCommon findingProgressionHypertensionNephropathyPatientsRisk variantsGenetic backgroundEtiologyDiseaseDiagnosisSuspicion
2016
2016 Dietary Salt Fact Sheet and Call to Action: The World Hypertension League, International Society of Hypertension, and the International Council of Cardiovascular Prevention and Rehabilitation
Campbell NR, Lackland DT, Niebylski ML, Orias M, Redburn KA, Nilsson PM, Zhang X, Burrell L, Horiuchi M, Poulter NR, Prabhakaran D, Ramirez AJ, Schiffrin EL, Schutte AE, Touyz RM, Wang J, Weber MA, Prevention and Rehabilitation I. 2016 Dietary Salt Fact Sheet and Call to Action: The World Hypertension League, International Society of Hypertension, and the International Council of Cardiovascular Prevention and Rehabilitation. Journal Of Clinical Hypertension 2016, 18: 1082-1085. PMID: 27515460, PMCID: PMC8032122, DOI: 10.1111/jch.12894.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsHigh Blood Pressure 2016: Why Prevention and Control Are Urgent and Important. The World Hypertension League, International Society of Hypertension, World Stroke Organization, International Diabetes Foundation, International Council of Cardiovascular Prevention and Rehabilitation, International Society of Nephrology
Campbell NR, Khalsa T, Executive: W, Lackland DT, Niebylski ML, Nilsson PM, Redburn KA, Orias M, Zhang X, Executive: I, Burrell L, Horiuchi M, Poulter NR, Prabhakaran D, Ramirez AJ, Schiffrin EL, Touyz RM, Wang J, Weber MA, Organization W, Federation I, Prevention and Rehabilitation I, Society of Nephrology I. High Blood Pressure 2016: Why Prevention and Control Are Urgent and Important. The World Hypertension League, International Society of Hypertension, World Stroke Organization, International Diabetes Foundation, International Council of Cardiovascular Prevention and Rehabilitation, International Society of Nephrology. Journal Of Clinical Hypertension 2016, 18: 714-717. PMID: 27316336, PMCID: PMC8031792, DOI: 10.1111/jch.12840.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2014
Estimated GFR or Albuminuria: Which One Is Really Associated With Resistant Hypertension?
Romero CA, Peixoto AJ, Orias M. Estimated GFR or Albuminuria: Which One Is Really Associated With Resistant Hypertension? Seminars In Nephrology 2014, 34: 492-497. PMID: 25416657, DOI: 10.1016/j.semnephrol.2014.08.002.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsLow estimated glomerular filtration rateEstimated glomerular filtration rateResistant hypertensionGlomerular filtration rateFiltration rateHigh cardiovascular risk groupTarget organ damageComplications of hypertensionCardiovascular risk groupsHigher sympathetic activityEndothelial dysfunctionFluid overloadSympathetic activityOrgan damageKidney diseaseRisk groupsHigh prevalenceHypertensionMicroalbuminuriaPrevalenceDifferent phenotypesPhenotypeAlbuminuriaComplicationsGFR
2013
Hemodynamic circulatory patterns in young patients with predominantly diastolic hypertension
Romero CA, Alfie J, Galarza C, Waisman G, Peixoto AJ, Tabares AH, Orias M. Hemodynamic circulatory patterns in young patients with predominantly diastolic hypertension. International Journal Of Cardiology Cardiovascular Risk And Prevention 2013, 7: 157-162. PMID: 23403215, DOI: 10.1016/j.jash.2013.01.001.Peer-Reviewed Original ResearchConceptsSystemic vascular resistanceStroke volume indexDiastolic hypertensionCardiac indexHemodynamic patternsHeart rateTotal arterial compliance indexAmbulatory blood pressure monitoringHigher systemic vascular resistanceNormal systemic vascular resistanceArterial compliance indexLow cardiac indexHigher cardiac indexBlood pressure monitoringSVR groupVascular resistanceYounger patientsBlood pressureHypertensive individualsHypertension patientsPathophysiologic mechanismsMean agePulse pressureHypertensionPressure monitoringDoes Kidney Disease Cause Hypertension?
Peixoto AJ, Orias M, Desir GV. Does Kidney Disease Cause Hypertension? Current Hypertension Reports 2013, 15: 89-94. PMID: 23344662, DOI: 10.1007/s11906-013-0327-6.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsChronic kidney diseaseKidney diseaseRenal functionStructural kidney diseaseGlomerular filtration ratePlasmin-mediated activationExtracellular fluid volumeProteinuric glomerular diseasesPolycystic kidney diseaseChronic hypertensionHypertension increasesEpithelial sodium channelSodium retentionFiltration rateGlomerular diseaseHypertensionCurrent evidenceDiseaseSodium channelsFluid volumeDetectable changeSevere reductionMost casesProteinuriaPatients
2010
Hypothesis: It Is Time to Reconsider Phenotypes in Hypertension
Orias M, Tabares AH, Peixoto AJ. Hypothesis: It Is Time to Reconsider Phenotypes in Hypertension. Journal Of Clinical Hypertension 2010, 12: 350-356. PMID: 20546376, PMCID: PMC8673086, DOI: 10.1111/j.1751-7176.2010.00266.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2007
Association of ACE genotype and predominantly diastolic hypertension: a preliminary study
Jiménez PM, Conde C, Casanegra A, Romero C, Hugo Tabares A, Orías M. Association of ACE genotype and predominantly diastolic hypertension: a preliminary study. Journal Of The Renin-Angiotensin-Aldosterone System 2007, 8: 42-44. PMID: 17487825, DOI: 10.3317/jraas.2007.006.Peer-Reviewed Original ResearchConceptsPDH patientsDiastolic hypertensionBlood pressureGenotype distributionACE I/D polymorphismAngiotensin-converting enzyme polymorphismACE genotype DDAngiotensin II activityNormotensive control individualsCardiovascular risk factorsHigher plasma ACE levelsSystolic blood pressurePlasma ACE levelsChi-square testMmHg systolicEssential hypertensionPeripheral resistanceNormotensive controlsACE genotypeACE levelsRisk factorsDD genotypeD polymorphismHypertensionPatients
2003
P-118: Association of the DD ACE polymorphism and predominantly diastolic hypertension
Orias M, Jimenez P, Conde C, Tabares A. P-118: Association of the DD ACE polymorphism and predominantly diastolic hypertension. American Journal Of Hypertension 2003, 16: 81a-82a. DOI: 10.1016/s0895-7061(03)00284-x.Peer-Reviewed Original ResearchAmbulatory blood pressure monitoringDiastolic hypertensionACE polymorphismHg diastolic blood pressureAngiotensin II activityNormotensive control individualsCardiovascular risk factorsDiastolic blood pressureBlood pressure monitoringPDH patientsHg systolicHypertensive patientsBlood pressureEssential hypertensionNormotensive controlsPeripheral resistanceACE genotypeRisk factorsDD genotypeHypertensionPressure monitoringPatientsControl individualsGenotype variantsSystolic ratio
2000
C037: Reproducibility of ambulatory blood pressure in hemodialysis patients
Peixoto A, Santos S, Mendes R, Crowley S, Orias M, Maldonado R, Mansoor G, White W. C037: Reproducibility of ambulatory blood pressure in hemodialysis patients. American Journal Of Hypertension 2000, 13: 223a-223a. DOI: 10.1016/s0895-7061(00)00757-3.Peer-Reviewed Original Research
1998
Blood pressure regulation by potassium channels.
Orias M. Blood pressure regulation by potassium channels. Medicina 1998, 58: 429-32. PMID: 9816709.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPotassium channelsK-ATP channel openerVascular smooth muscle contractionBlood pressure regulationVessel smooth muscleSmooth muscle contractionIntracellular calcium levelsEssential hypertensionHypoxic vasodilatationChannel openersExcessive activationSmooth muscleCalcium levelsPressure regulationMuscle contractionMembrane potentialHypertensionVasodilatationDiazoxidePathogenesisMinoxidil