2023
Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study
Datta R, Han L, Doyle M, Allore H, Sanft T, Quagliarello V, Juthani-Mehta M. Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study. Palliative Medicine 2023, 37: 793-798. PMID: 36999898, DOI: 10.1177/02692163231162889.Peer-Reviewed Original ResearchConceptsAdverse drug eventsAntibiotic therapyDrug eventsAdvanced cancerOlder adultsIndex admissionPalliative chemotherapyCohort studyTertiary care centerHospitalized older adultsPalliative care providersMultidrug-resistant organismsMean ageCommon tumorsCare centerCare providersRatio of daysSolid tumorsMultivariable testingPatientsTherapyStandardized criteriaCancerMean timeAdults
2020
Education needed to improve antimicrobial use during end-of-life care of older adults with advanced cancer: A cross-sectional survey
Datta R, Topal J, McManus D, Sanft T, Dembry LM, Morrison LJ, Quagliarello V, Juthani-Mehta M. Education needed to improve antimicrobial use during end-of-life care of older adults with advanced cancer: A cross-sectional survey. Palliative Medicine 2020, 35: 236-241. PMID: 32928066, DOI: 10.1177/0269216320956811.Peer-Reviewed Original ResearchConceptsEscalation of careAdvance care planningLife careAdvanced cancerCross-sectional surveyIntravenous antimicrobialsOlder adultsAntimicrobial useCare planningSingle-center cross-sectional surveyEducational interventionAdvance care plansRole of antimicrobialsClinical deteriorationPercent of respondentsAdverse eventsOral antimicrobialsMedicine subspecialistsCare plansInpatient medicineCareCancerPatientsAdultsSubspecialists
2019
Increased Length of Stay Associated With Antibiotic Use in Older Adults With Advanced Cancer Transitioned to Comfort Measures
Datta R, Zhu M, Han L, Allore H, Quagliarello V, Juthani-Mehta M. Increased Length of Stay Associated With Antibiotic Use in Older Adults With Advanced Cancer Transitioned to Comfort Measures. American Journal Of Hospice And Palliative Medicine® 2019, 37: 27-33. PMID: 31185722, PMCID: PMC6868290, DOI: 10.1177/1049909119855617.Peer-Reviewed Original ResearchConceptsAdvanced cancerAntibiotic useComfort measuresPoisson regression modelsInfection diagnosisIntensive care unit admissionMultivariable Poisson regression modelsCare unit admissionCohort of patientsUrinary tract infectionGoal-concordant careUnit admissionEnd of lifeHospital lengthOlder patientsTract infectionsLonger LOSMedian ageRegression modelsStay AssociatedAntibiotic exposureLiquid tumorsPatientsCancerCancer typesClinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of Americaa
Nicolle LE, Gupta K, Bradley SF, Colgan R, DeMuri GP, Drekonja D, Eckert LO, Geerlings SE, Köves B, Hooton TM, Juthani-Mehta M, Knight SL, Saint S, Schaeffer AJ, Trautner B, Wullt B, Siemieniuk R. Clinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of Americaa. Clinical Infectious Diseases 2019, 68: 1611-1615. PMID: 31506700, DOI: 10.1093/cid/ciz021.Peer-Reviewed Original ResearchConceptsAsymptomatic bacteriuriaInfectious Diseases SocietyDiseases SocietyHealthy womenSolid organ transplantsClinical practice guidelinesSpinal cord injuryInvasive urologic proceduresNonurologic surgeryUrologic abnormalitiesClinical symptomsPregnant womenCord injuryCurrent guidelinesCommon findingHigh prevalencePractice guidelinesOrgan transplantsOlder womenUrologic proceduresAntimicrobial treatmentAdult populationAntimicrobial useAntimicrobial resistanceWomenClinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of Americaa
Nicolle LE, Gupta K, Bradley SF, Colgan R, DeMuri GP, Drekonja D, Eckert LO, Geerlings SE, Köves B, Hooton TM, Juthani-Mehta M, Knight SL, Saint S, Schaeffer AJ, Trautner B, Wullt B, Siemieniuk R. Clinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of Americaa. Clinical Infectious Diseases 2019, 68: e83-e110. PMID: 30895288, DOI: 10.1093/cid/ciy1121.Peer-Reviewed Original ResearchConceptsAsymptomatic bacteriuriaInfectious Diseases SocietyDiseases SocietyHealthy womenSolid organ transplantsClinical practice guidelinesSpinal cord injuryInvasive urologic proceduresNonurologic surgeryUrologic abnormalitiesClinical symptomsPregnant womenCord injuryCurrent guidelinesCommon findingHigh prevalencePractice guidelinesOrgan transplantsOlder womenUrologic proceduresAntimicrobial treatmentAdult populationAntimicrobial useAntimicrobial resistanceWomenAntimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures
Datta R, Wang T, Zhu M, Dembry LM, Han L, Allore H, Quagliarello V, Juthani-Mehta M. Antimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures. Infection Control And Hospital Epidemiology 2019, 40: 470-472. PMID: 30821230, PMCID: PMC6482377, DOI: 10.1017/ice.2019.22.Peer-Reviewed Original ResearchConceptsUrinary tract infectionIncidence rate ratiosAdvanced cancer patientsAsymptomatic bacteriuriaCancer patientsAntimicrobial therapySymptomatic urinary tract infectionPotential urinary tract infectionTract infectionsInappropriate therapyAntimicrobial daysComfort measuresBacteriuriaCandiduriaCFU/mLPatientsTherapyRate ratioMLInfectionOlder men may benefit from antimicrobial prophylaxis for recurrent urinary tract infections
Mody L, Juthani-Mehta M. Older men may benefit from antimicrobial prophylaxis for recurrent urinary tract infections. Age And Ageing 2019, 48: 167-168. PMID: 30715095, DOI: 10.1093/ageing/afy195.Peer-Reviewed Original Research
2018
Uncomplicated Cystitis in Nursing Home Residents: A Practical Guide to Diagnosis and Management
Datta R, Juthani-Mehta M. Uncomplicated Cystitis in Nursing Home Residents: A Practical Guide to Diagnosis and Management. Journal Of The American Medical Directors Association 2018, 19: 733-735. PMID: 30149841, PMCID: PMC6510384, DOI: 10.1016/j.jamda.2018.07.015.Commentaries, Editorials and Letters
2016
Effect of Cranberry Capsules on Bacteriuria Plus Pyuria Among Older Women in Nursing Homes: A Randomized Clinical Trial
Juthani-Mehta M, Van Ness PH, Bianco L, Rink A, Rubeck S, Ginter S, Argraves S, Charpentier P, Acampora D, Trentalange M, Quagliarello V, Peduzzi P. Effect of Cranberry Capsules on Bacteriuria Plus Pyuria Among Older Women in Nursing Homes: A Randomized Clinical Trial. JAMA 2016, 316: 1879-1887. PMID: 27787564, PMCID: PMC5300771, DOI: 10.1001/jama.2016.16141.Peer-Reviewed Original ResearchConceptsUrinary tract infectionPresence of bacteriuriaSymptomatic urinary tract infectionCranberry capsulesNursing homesOlder womenTreatment groupsControl groupPlacebo-controlled efficacy trialSignificant differencesRate of deathAntibiotic-resistant organismsControl group participantsCause deathStudy surveillanceCause hospitalizationSecondary outcomesTract infectionsPrimary outcomeOverall adherenceAntimicrobial utilizationClinical trialsEfficacy trialsPyuriaUnadjusted results
2015
Antibiotic Susceptibility of Urinary Isolates in Nursing Home Residents Consuming Cranberry Capsules Versus Placebo
Madden GR, Argraves SM, Van Ness PH, Juthani-Mehta M. Antibiotic Susceptibility of Urinary Isolates in Nursing Home Residents Consuming Cranberry Capsules Versus Placebo. Infection Control And Hospital Epidemiology 2015, 36: 356-357. PMID: 25695180, PMCID: PMC4336946, DOI: 10.1017/ice.2014.66.Peer-Reviewed Original Research
2014
A Cluster-Randomized Controlled Trial of a Multicomponent Intervention Protocol for Pneumonia Prevention Among Nursing Home Elders
Juthani-Mehta M, Van Ness PH, McGloin J, Argraves S, Chen S, Charpentier P, Miller L, Williams K, Wall D, Baker D, Tinetti M, Peduzzi P, Quagliarello VJ. A Cluster-Randomized Controlled Trial of a Multicomponent Intervention Protocol for Pneumonia Prevention Among Nursing Home Elders. Clinical Infectious Diseases 2014, 60: 849-857. PMID: 25520333, PMCID: PMC4415071, DOI: 10.1093/cid/ciu935.Peer-Reviewed Original ResearchConceptsNursing home residentsUsual careHome residentsIntervention protocolFirst pneumoniaControl armClinical trialsNursing homesMultivariable Cox regression modelsElderly nursing home residentsCluster-randomized clinical trialImportant public health problemChlorhexidine oral rinseModifiable risk factorsRespiratory tract infectionsCox regression modelNursing home eldersPublic health problemHazard ratioPneumonia preventionSecondary outcomesTract infectionsControlled TrialsPrimary outcomeOral rinseTests for Urinary Tract Infection in Nursing Home Residents
Juthani-Mehta M, Datunashvili A, Tinetti M. Tests for Urinary Tract Infection in Nursing Home Residents. JAMA 2014, 312: 1687-1688. PMID: 25335152, DOI: 10.1001/jama.2014.13554.Peer-Reviewed Original ResearchUrinary Tract Infections in Older Women
Mody L, Juthani-Mehta M. Urinary Tract Infections in Older Women. JAMA 2014, 311: 874-874. PMID: 24570259, PMCID: PMC4237003, DOI: 10.1001/jama.2014.1152.Peer-Reviewed Original ResearchUrinary Tract Infections in Older Women: A Clinical Review
Mody L, Juthani-Mehta M. Urinary Tract Infections in Older Women: A Clinical Review. JAMA 2014, 311: 844-854. PMID: 24570248, PMCID: PMC4194886, DOI: 10.1001/jama.2014.303.Peer-Reviewed Original ResearchConceptsSymptomatic urinary tract infectionRecurrent urinary tract infectionsUrinary tract infectionAsymptomatic bacteriuriaOlder womenTract infectionsUrine cultureRecurrent symptomatic urinary tract infectionsDiagnosis of UTIOlder community-dwelling womenEnglish-language human studiesChronic suppressive antibioticsCostovertebral angle painNegative dipstick resultsSymptomatic UTI episodesVaginal estrogen therapyAdverse effect profilePositive urine cultureLocal resistance ratesCommunity-dwelling womenLow pretest probabilityCareful clinical evaluationClinical diagnostic criteriaSearch of OvidRecent sexual intercourse
2013
Diagnosis and Management of Urinary Tract Infection in Older Adults
Rowe TA, Juthani-Mehta M. Diagnosis and Management of Urinary Tract Infection in Older Adults. Infectious Disease Clinics Of North America 2013, 28: 75-89. PMID: 24484576, PMCID: PMC4079031, DOI: 10.1016/j.idc.2013.10.004.Peer-Reviewed Original ResearchModifiable Risk Factors for Pneumonia Requiring Hospitalization of Community‐Dwelling Older Adults: The Health, Aging, and Body Composition Study
Juthani‐Mehta M, De Rekeneire N, Allore H, Chen S, O'Leary JR, Bauer DC, Harris TB, Newman AB, Yende S, Weyant RJ, Kritchevsky S, Quagliarello V, Study F. Modifiable Risk Factors for Pneumonia Requiring Hospitalization of Community‐Dwelling Older Adults: The Health, Aging, and Body Composition Study. Journal Of The American Geriatrics Society 2013, 61: 1111-1118. PMID: 23772872, PMCID: PMC3714374, DOI: 10.1111/jgs.12325.Peer-Reviewed Original ResearchConceptsModifiable risk factorsIncident mobility limitationCommunity-dwelling older adultsBody Composition StudyRisk factorsPlaque scoresMobility limitationsOlder adultsNovel modifiable risk factorsProspective observational cohort studyObservational cohort studyNonmodifiable risk factorsCases of pneumoniaHistory of pneumoniaCommunity-dwelling adultsAverage attributable fractionMonths of baselineCohort studyExpiratory volumePneumonia preventionDental examinationPrimary outcomeOral hygieneMale sexAttributable fractionLack of Positive Association Between Falls and Bacteriuria Plus Pyuria in Older Nursing Home Residents
Rowe T, Towle V, Van Ness P, Juthani‐Mehta M. Lack of Positive Association Between Falls and Bacteriuria Plus Pyuria in Older Nursing Home Residents. Journal Of The American Geriatrics Society 2013, 61: 653-654. PMID: 23581923, PMCID: PMC3628627, DOI: 10.1111/jgs.12177.Peer-Reviewed Original Research
2011
Adverse Outcomes in Nursing Home Residents with Increased Episodes of Observed Bacteriuria
Das R, Towle V, Ness P, Juthani-Mehta M. Adverse Outcomes in Nursing Home Residents with Increased Episodes of Observed Bacteriuria. Infection Control And Hospital Epidemiology 2011, 32: 84-86. PMID: 21091203, PMCID: PMC3089439, DOI: 10.1086/657664.Peer-Reviewed Original Research
2010
Infectious Diseases in the Nursing Home Setting: Challenges and Opportunities for Clinical Investigation
High K, Juthani-Mehta M, Quagliarello V. Infectious Diseases in the Nursing Home Setting: Challenges and Opportunities for Clinical Investigation. Clinical Infectious Diseases 2010, 51: 931-936. PMID: 20822459, PMCID: PMC3083824, DOI: 10.1086/656411.Peer-Reviewed Original ResearchConceptsNursing home residentsHome residentsInfectious diseasesNursing homesNursing home settingMultiple comorbid diseasesPublic health problemComorbid diseasesHigh prevalenceFunctional declineClinical investigationPhysician investigatorsHealth problemsDiseaseHome settingOlder AmericansUnique issuesResidentsImmunosenescencePrognosisDementiaInfectionPrevalenceDiagnosisFEASIBILITY OF CRANBERRY CAPSULE ADMINISTRATION AND CLEAN‐CATCH URINE COLLECTION IN LONG‐TERM CARE RESIDENTS
Juthani‐Mehta M, Perley L, Chen S, Dziura J, Gupta K. FEASIBILITY OF CRANBERRY CAPSULE ADMINISTRATION AND CLEAN‐CATCH URINE COLLECTION IN LONG‐TERM CARE RESIDENTS. Journal Of The American Geriatrics Society 2010, 58: 2028-2030. PMID: 20929476, PMCID: PMC2953731, DOI: 10.1111/j.1532-5415.2010.03080.x.Peer-Reviewed Original Research