2024
Impact of a multicomponent strategy including decentralized molecular testing for tuberculosis on mortality: planned analysis of a cluster-randomized trial in Uganda
Katamba A, Mochizuki T, Nalugwa T, Nantale M, Oyuku D, Nabwire S, Babirye D, Musinguzi J, Nakawesa A, Nekesa I, Turyahabwe S, Joloba M, Dowdy D, Moore D, Davis J, Shete P, Adams K, Reza T, Fielding K, Cattamanchi A. Impact of a multicomponent strategy including decentralized molecular testing for tuberculosis on mortality: planned analysis of a cluster-randomized trial in Uganda. EClinicalMedicine 2024, 78: 102953. PMCID: PMC11629260, DOI: 10.1016/j.eclinm.2024.102953.Peer-Reviewed Original ResearchCommunity health centersCluster randomized trialHealth centersPragmatic cluster randomized trialMulticomponent strategiesSix-month mortality riskSecondary outcomesPan African Clinical Trials RegistryCluster-level analysisPatient-level covariatesAll-cause mortalityClinical Trials RegistryIntervention armSub-group analysisTB careMortality risk analysisRoutine careVital statusTrial armsMagnitude of effectPresumptive TBRate ratiosProximal outcomesTrial participantsUS National Institutes
2021
Multicomponent Strategy with Decentralized Molecular Testing for Tuberculosis
Cattamanchi A, Reza T, Nalugwa T, Adams K, Nantale M, Oyuku D, Nabwire S, Babirye D, Turyahabwe S, Tucker A, Sohn H, Ferguson O, Thompson R, Shete P, Handley M, Ackerman S, Joloba M, Moore D, Davis J, Dowdy D, Fielding K, Katamba A. Multicomponent Strategy with Decentralized Molecular Testing for Tuberculosis. New England Journal Of Medicine 2021, 385: 2441-2450. PMID: 34936740, PMCID: PMC9212879, DOI: 10.1056/nejmoa2105470.Peer-Reviewed Original ResearchConceptsSame-day treatmentSame-day diagnosisHealth centersMolecular testingTuberculosis testingHuman immunodeficiency virus (HIV) infectionDiagnostic strategiesImmunodeficiency virus infectionCommunity health centersCluster-randomized trialTreatment of tuberculosisSecondary outcomesMore patientsPrimary outcomePrompt diagnosisRoutine careEligible adultsIntervention groupIntervention periodHigh burdenVirus infectionIntervention centersControl groupPatientsTuberculosis
2019
Home-based tuberculosis contact investigation in Uganda: a household randomised trial
Davis JL, Turimumahoro P, Meyer AJ, Ayakaka I, Ochom E, Ggita J, Mark D, Babirye D, Okello DA, Mugabe F, Fair E, Vittinghoff E, Armstrong-Hough M, Dowdy D, Cattamanchi A, Haberer JE, Katamba A. Home-based tuberculosis contact investigation in Uganda: a household randomised trial. ERJ Open Research 2019, 5: 00112-2019. PMID: 31367636, PMCID: PMC6661318, DOI: 10.1183/23120541.00112-2019.Peer-Reviewed Original ResearchCommunity health workersTB contact investigationTuberculosis contact investigationContact investigationTB evaluationIndex patientsWorld Health OrganizationIntervention armHousehold tuberculosis contact investigationCare armHousehold contactsPulmonary TBSputum testingCare contactsHIV diagnosisSecondary outcomesHIV testingPrimary outcomeSymptomatic contactsHealth workersMicrobiologic testingHome evaluationIntervention componentsSputumPatients