2019
Early Colonoscopy Does Not Improve Outcomes of Patients With Lower Gastrointestinal Bleeding: Systematic Review of Randomized Trials
Tsay C, Shung D, Stemmer Frumento K, Laine L. Early Colonoscopy Does Not Improve Outcomes of Patients With Lower Gastrointestinal Bleeding: Systematic Review of Randomized Trials. Clinical Gastroenterology And Hepatology 2019, 18: 1696-1703.e2. PMID: 31843595, PMCID: PMC7292779, DOI: 10.1016/j.cgh.2019.11.061.Peer-Reviewed Original ResearchConceptsAcute lower gastrointestinal bleedingLower gastrointestinal bleedingRandomized trialsEarly colonoscopyElective colonoscopyGastrointestinal bleedingSecondary outcomesHemostatic interventionEndoscopic interventionDiagnostic yieldSevere acute lower gastrointestinal bleedingSystematic reviewDual independent reviewTiming of colonoscopyOutcomes of patientsHours of presentationRandom-effects modelRecurrent bleedingPrimary outcomeIndex examinationColonoscopy evaluationBias assessmentObservational studyBleedingColonoscopyColonoscopy for Lower Gastrointestinal Bleeding—Time Is Not of the Essence
Laine L. Colonoscopy for Lower Gastrointestinal Bleeding—Time Is Not of the Essence. Gastroenterology 2019, 158: 38-39. PMID: 31730767, DOI: 10.1053/j.gastro.2019.11.009.Commentaries, Editorials and Letters
2018
Impact of Changeover to Newer Endoscopic Systems on Quality and Efficiency of Screening and Surveillance Colonoscopy
Singh M, Sacatos M, Laine L. Impact of Changeover to Newer Endoscopic Systems on Quality and Efficiency of Screening and Surveillance Colonoscopy. Journal Of Clinical Gastroenterology 2018, 52: 891-895. PMID: 28906425, DOI: 10.1097/mcg.0000000000000931.Peer-Reviewed Original Research
2017
Optimizing the quality of endoscopy in inflammatory bowel disease: focus on surveillance and management of colorectal dysplasia using interactive image- and video-based teaching
Kaltenbach TR, Soetikno RM, DeVivo R, Laine LA, Barkun A, McQuaid KR, Group O, Cheifetz A, Chiorean M, East J, Farraye F, Leighton J, Levesque B, Lichtenstein G, Marion J, Matsumoto T, Mönkemüller K, Picco M, Odze R, Raju G, Rutter M, Rex D, Shen B, Shergill A, Subramanian V. Optimizing the quality of endoscopy in inflammatory bowel disease: focus on surveillance and management of colorectal dysplasia using interactive image- and video-based teaching. Gastrointestinal Endoscopy 2017, 86: 1107-1117.e1. PMID: 28818507, DOI: 10.1016/j.gie.2017.07.045.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseManagement of dysplasiaUse of chromoendoscopyVisible dysplastic lesionsIBD surveillanceQuiescent diseaseBowel diseaseDysplastic lesionsDysplasia detectionColonic inflammatory bowel diseaseColorectal Endoscopic Neoplasia DetectionInflammatory bowel disease patientsBowel disease patientsUptake of strategiesQuality of endoscopyInternational consensus recommendationsEvidence-based advancesAcademic medical centerDetection of dysplasiaImage-enhanced endoscopyUse of EMRDysplasia managementIBD courseColorectal dysplasiaDisease activityContinued midazolam versus diphenhydramine in difficult-to-sedate patients: a randomized double-blind trial
Sachar H, Pichetshote N, Nandigam K, Vaidya K, Laine L. Continued midazolam versus diphenhydramine in difficult-to-sedate patients: a randomized double-blind trial. Gastrointestinal Endoscopy 2017, 87: 1297-1303. PMID: 28159539, PMCID: PMC5537051, DOI: 10.1016/j.gie.2017.01.028.Peer-Reviewed Original ResearchConceptsDouble-blind trialAdequate sedationStudy medicationModerate sedationAlertness/Sedation scoreAdequacy of sedationStudy medication dosePsychiatric medication useModified Observer's AssessmentMOAA/SAdditional medicationElective colonoscopyPrimary endpointOpioid combinationsOpioid useMedication useMore patientsSedation scoreSuch patientsMedication doseUsual dosesBenzodiazepine useCurrent guidelinesSedate patientsSedation
2016
Diagnosis of sessile serrated adenomas/polyps with image-enhanced endoscopy: a systematic review and meta-analysis
Parikh ND, Chaptini L, Njei B, Laine L. Diagnosis of sessile serrated adenomas/polyps with image-enhanced endoscopy: a systematic review and meta-analysis. Endoscopy 2016, 48: 731-739. PMID: 27223636, DOI: 10.1055/s-0042-107592.Peer-Reviewed Original ResearchConceptsImage-enhanced endoscopyWhite light endoscopyNarrow-band imagingNon-neoplastic lesionsSSA/PsAdenomas/polypsFlexible spectral imaging color enhancementSystematic reviewCorresponding histologic diagnosesSSA/P detection rateSessile serrated adenomas/polypsSerrated adenomas/polypsNon-neoplastic tissuesAppearance of polypsSSA/PNBI studiesPrimary outcomeHistologic diagnosisInclusion criteriaEndoscopic diagnosisHyperplastic polypsSSA/P.Autofluorescence imagingHead comparisonBand imagingParadigm Shift in the Surveillance and Management of Dysplasia in Inflammatory Bowel Disease (West)
Soetikno R, Kaltenbach T, McQuaid KR, Subramanian V, Kumar R, Barkun AN, Laine L. Paradigm Shift in the Surveillance and Management of Dysplasia in Inflammatory Bowel Disease (West). Digestive Endoscopy 2016, 28: 266-273. PMID: 26866420, DOI: 10.1111/den.12634.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsManagement of dysplasiaColorectal cancerUlcerative colitisInflammatory bowel disease colitisCrohn's disease (CD) colitisInflammatory bowel diseaseEarly colorectal cancerDysplasia associated lesionHigh-definition colonoscopyInstitute of MedicineNew surveillance paradigmMost dysplasiaColorectal dysplasiaResectable lesionsSurveillance colonoscopyBowel diseaseGRADE methodologyAssociated lesionsTargeted biopsiesConsensus statementHigh riskGeneral populationEndoscopic recognitionGuideline developmentDysplasiaHigh-quality Bowel Preparation Is Required for Detection of Sessile Serrated Polyps
Clark BT, Laine L. High-quality Bowel Preparation Is Required for Detection of Sessile Serrated Polyps. Clinical Gastroenterology And Hepatology 2016, 14: 1155-1162. PMID: 27060426, PMCID: PMC4955697, DOI: 10.1016/j.cgh.2016.03.044.Peer-Reviewed Original ResearchMeSH KeywordsAdenomaAgedColonoscopyColorectal NeoplasmsHumansMaleMiddle AgedPolypsPreoperative CareProspective StudiesConceptsSessile serrated adenomas/polypsBowel preparation qualityProportion of patientsDetection of adenomasPreparation qualityRight colonBBPS scoresHigh-quality bowel preparationBoston Bowel Preparation ScaleMultivariate logistic regressionBowel Preparation ScaleSerrated adenomas/polypsSessile serrated polypsAdenomas/polypsSurveillance colonoscopyBowel preparationProspective studyAronchick scaleEntire colonSmall proportionSerrated polypsPatientsPreparation ScaleScoring systemAbstractTextYield of repeat forward-view examination of the right side of the colon in screening and surveillance colonoscopy
Clark BT, Parikh ND, Laine L. Yield of repeat forward-view examination of the right side of the colon in screening and surveillance colonoscopy. Gastrointestinal Endoscopy 2016, 84: 126-132. PMID: 26769408, PMCID: PMC4912931, DOI: 10.1016/j.gie.2015.12.030.Peer-Reviewed Original ResearchConceptsAdenoma detection rateForward-view examinationOverall adenoma detection rateSecond examinationRight sideSurveillance colonoscopyAdditional adenomasWest Haven Veterans Affairs Medical CenterVeterans Affairs Medical CenterBoston Bowel Preparation Scale scoreDistal colon cancerNumber of patientsYears of ageDevelopment of cancerSecondary outcomesPrimary outcomeMen 50Prospective studySurveillance intervalsAdenoma detectionDetection rateMedical CenterInitial examinationPatientsColon cancer
2015
Quantification of Adequate Bowel Preparation for Screening or Surveillance Colonoscopy in Men
Clark BT, Protiva P, Nagar A, Imaeda A, Ciarleglio MM, Deng Y, Laine L. Quantification of Adequate Bowel Preparation for Screening or Surveillance Colonoscopy in Men. Gastroenterology 2015, 150: 396-405. PMID: 26439436, PMCID: PMC4728019, DOI: 10.1053/j.gastro.2015.09.041.Peer-Reviewed Original ResearchConceptsAdequate bowel preparationBBPS scoreSurveillance colonoscopyBowel preparationColon segmentsBBPS scoresSecond examinationWest Haven Veterans Affairs Medical CenterVeterans Affairs Medical CenterFirst examinationGuideline-recommended intervalsProspective observational studyDetection of adenomasIdentification of polypsColonoscopic evaluationPrimary outcomeSurveillance intervalsBlinded endoscopistsColonoscopy examinationObservational studyPrEP scaleMedical CenterInitial examinationStudy subjectsAdequate preparationA roadmap to the implementation of chromoendoscopy in inflammatory bowel disease colonoscopy surveillance practice
Sanduleanu S, Kaltenbach T, Barkun A, McCabe RP, Velayos F, Picco MF, Laine L, Soetikno R, McQuaid KR. A roadmap to the implementation of chromoendoscopy in inflammatory bowel disease colonoscopy surveillance practice. Gastrointestinal Endoscopy 2015, 83: 213-222. PMID: 26364967, DOI: 10.1016/j.gie.2015.08.076.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsManagement of Diminutive Colon Polyps Based on Endoluminal Imaging
Lieberman D, Brill J, Canto M, DeMarco D, Fennerty B, Gupta N, Laine L, Lightdale C, Montgomery E, Odze R, Rex D, Sharma P, Kochman M, Tokar J. Management of Diminutive Colon Polyps Based on Endoluminal Imaging. Clinical Gastroenterology And Hepatology 2015, 13: 1860-1866. PMID: 26192139, DOI: 10.1016/j.cgh.2015.07.011.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDiminutive colon polypsSuch polypsColon polypsAppropriate surveillance intervalsNegative predictive valuePatient education needsDiminutive hyperplastic polypsEndoluminal imagingNon-neoplastic polypsEndoscopic impressionPathologic evaluationSurveillance intervalsPathologic diagnosisDiminutive adenomasHyperplastic polypsSerious pathologyClinical practicePredictive valuePolypsPractice changeVivo studiesExpert panelAdenomasPotential cost benefitsRiskCan I Improve My Adenoma Detection Rate?
Chaptini L, Laine L. Can I Improve My Adenoma Detection Rate? Journal Of Clinical Gastroenterology 2015, 49: 270-281. PMID: 25647725, DOI: 10.1097/mcg.0000000000000293.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSCENIC International Consensus Statement on Surveillance and Management of Dysplasia in Inflammatory Bowel Disease
Laine L, Kaltenbach T, Barkun A, McQuaid KR, Subramanian V, Soetikno R, Panel S, East J, Farraye F, Feagan B, Ioannidis J, Kiesslich R, Krier M, Matsumoto T, McCabe R, Mönkemüller K, Odze R, Picco M, Rubin D, Rubin M, Rubio C, Rutter M, Sanchez-Yague A, Sanduleanu S, Shergill A, Ullman T, Velayos F, Yakich D, Yang Y. SCENIC International Consensus Statement on Surveillance and Management of Dysplasia in Inflammatory Bowel Disease. Gastroenterology 2015, 148: 639-651.e28. PMID: 25702852, DOI: 10.1053/j.gastro.2015.01.031.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSCENIC international consensus statement on surveillance and management of dysplasia in inflammatory bowel disease
Laine L, Kaltenbach T, Barkun A, McQuaid KR, Subramanian V, Soetikno R, Panel S, East J, Farraye F, Feagan B, Ioannidis J, Kiesslich R, Krier M, Matsumoto T, McCabe R, Mönkemüller K, Odze R, Picco M, Rubin D, Rubin M, Rubio C, Rutter M, Sanchez-Yague A, Sanduleanu S, Shergill A, Ullman T, Velayos F, Yakich D, Yang Y. SCENIC international consensus statement on surveillance and management of dysplasia in inflammatory bowel disease. Gastrointestinal Endoscopy 2015, 81: 489-501.e26. PMID: 25708752, DOI: 10.1016/j.gie.2014.12.009.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2014
What Level of Bowel Prep Quality Requires Early Repeat Colonoscopy: Systematic Review and Meta-Analysis of the Impact of Preparation Quality on Adenoma Detection Rate
Clark BT, Rustagi T, Laine L. What Level of Bowel Prep Quality Requires Early Repeat Colonoscopy: Systematic Review and Meta-Analysis of the Impact of Preparation Quality on Adenoma Detection Rate. The American Journal Of Gastroenterology 2014, 109: 1714. PMID: 25135006, PMCID: PMC4423726, DOI: 10.1038/ajg.2014.232.Peer-Reviewed Original ResearchVariation in polyp size estimation among endoscopists and impact on surveillance intervals
Chaptini L, Chaaya A, Depalma F, Hunter K, Peikin S, Laine L. Variation in polyp size estimation among endoscopists and impact on surveillance intervals. Gastrointestinal Endoscopy 2014, 80: 652-659. PMID: 24679658, DOI: 10.1016/j.gie.2014.01.053.Peer-Reviewed Original ResearchGastroenterologists’ Practice Patterns for Positive Fecal Occult Blood Test
Kim JJ, Han A, Yan AW, Cao D, Laine L. Gastroenterologists’ Practice Patterns for Positive Fecal Occult Blood Test. Journal Of Clinical Gastroenterology 2014, 48: 119-126. PMID: 23632353, DOI: 10.1097/mcg.0b013e31828f1c8d.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdultAnemia, Iron-DeficiencyColonoscopyDyspepsiaEndoscopy, GastrointestinalFemaleGastroenterologyHeartburnHumansInstitutional PracticeLaryngopharyngeal RefluxMaleMalpracticeMiddle AgedOccult BloodPractice Patterns, Physicians'Private PracticeProfessional Practice LocationTime FactorsConceptsPositive fecal occult blood testFecal occult blood testUpper GI symptomsOccult blood testGI symptomsBlood testsFear of litigationThird of gastroenterologistsColorectal cancer screeningPrivate practiceAdults 50 yearsIron deficiency anemiaDifferent daysGastrointestinal symptomsCancer screeningPractice patternsEsophagogastroduodenoscopyColonoscopyPotential respondersMultivariate analysisAnemiaFurther evaluationSymptomsSame dayPatients
2013
The yield and cost of colonoscopy in patients with metastatic cancer of unknown primary
Saliminejad M, Bemanian S, Ho A, Spiegel B, Laine L. The yield and cost of colonoscopy in patients with metastatic cancer of unknown primary. Alimentary Pharmacology & Therapeutics 2013, 38: 628-633. PMID: 23869398, DOI: 10.1111/apt.12429.Peer-Reviewed Original ResearchConceptsPrimary colon cancerCost of colonoscopyColon cancerColon primaryUnknown primaryMetastatic cancerVeterans Administration Medical CenterPalpable rectal massPrior colon cancerIron deficiency anemiaOccult bleedingAdvanced diseaseRectal massStandard indicationsDiagnostic colonoscopyEnrollment criteriaRoutine colonoscopyTargeted therapyColorectal lesionsMedical CenterExclusion criteriaColonoscopyPatientsCancer syndromesCancer
2010
Randomized Trial of Urgent vs. Elective Colonoscopy in Patients Hospitalized With Lower GI Bleeding
Laine L, Shah A. Randomized Trial of Urgent vs. Elective Colonoscopy in Patients Hospitalized With Lower GI Bleeding. The American Journal Of Gastroenterology 2010, 105: 2636. PMID: 20648004, DOI: 10.1038/ajg.2010.277.Peer-Reviewed Original ResearchConceptsLower GI bleedingElective colonoscopyUpper endoscopyUrgent colonoscopyGI bleedingBlood pressureHeart rateUpper gastrointestinal sourceUpper GI sourceUrgent upper endoscopyPrimary end pointDuration of hospitalizationSystolic blood pressureUnits of bloodEligible patientsUrgent groupElective groupHospital daysOrthostatic changesBlood transfusionClinical outcomesRandomized trialsHospital chargesVs. 5Gastrointestinal source