2022
Interferon activated gene 204 protects against bone loss in experimental periodontitis
Swanson KV, Girnary M, Alves T, Ting JP, Divaris K, Beck J, Pucinelli CM, da Silva RAB, Uyan D, Wilson JE, Seaman WT, Webster‐Cyriaque J, Vias N, Jiao Y, Cantley L, Marlier A, Arnold RR, Marchesan JT. Interferon activated gene 204 protects against bone loss in experimental periodontitis. The Journal Of Periodontology 2022, 93: 1366-1377. PMID: 35404474, PMCID: PMC9489626, DOI: 10.1002/jper.21-0668.Peer-Reviewed Original ResearchConceptsBone lossHuman endothelial cellsOsteoclast numberPeriodontal pathogensRecent human genetic association studiesHigher alveolar bone lossEndothelial cellsPeriodontal disease biomarkersAlveolar bone lossNeutrophils/macrophagesInterferon gamma-inducible protein 16Inflammatory cell traffickingInducible protein 16Periodontitis developmentChemokine responsesExperimental periodontitisInflammatory infiltrationPeriodontal destructionMarrow sourcesGingival tissuesMelanoma 2Periodontal tissuesLigature modelChimeric miceAlveolar bone
2013
Brg1 Determines Urothelial Cell Fate during Ureter Development
Weiss RM, Guo S, Shan A, Shi H, Romano RA, Sinha S, Cantley LG, Guo JK. Brg1 Determines Urothelial Cell Fate during Ureter Development. Journal Of The American Society Of Nephrology 2013, 24: 618-626. PMID: 23449535, PMCID: PMC3609140, DOI: 10.1681/asn.2012090902.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsUreter developmentBasal cell populationUreteral smooth muscle cellsHoxb7-CreTerminal differentiationPPARγ expressionUreteral epitheliumMuscle cellsUrothelial cellsP63 expressionRole of BRG1Basal cellsUmbrella cellsCell populationsSonic hedgehog expressionEpithelial stratificationAdult ureterUreterCell developmentBRG1 expressionSmooth muscle cell developmentShh expressionCellsHedgehog expression
2000
Hepatocyte growth factor induces MAPK-dependent formin IV translocation in renal epithelial cells.
O'Rourke DA, Liu ZX, Sellin L, Spokes K, Zeller R, Cantley L. Hepatocyte growth factor induces MAPK-dependent formin IV translocation in renal epithelial cells. Journal Of The American Society Of Nephrology 2000, 11: 2212-2221. PMID: 11095644, DOI: 10.1681/asn.v11122212.Peer-Reviewed Original ResearchConceptsFormin isoformsHepatocyte growth factorRenal epithelial cellsEpithelial tubule formationProtein kinase-dependent mannerUreteric bud outgrowthExtracellular signal-regulated kinaseQuiescent epithelial cellsEpithelial cellsFamily of proteinsProtein kinase inhibitor U0126Mitogen-activated protein kinase-dependent mannerKinase-dependent mannerMitogen-activated protein kinase inhibitor U0126Kinase inhibitor U0126Cell-matrix interactionsCell-cell interactionsGrowth factorSignal-regulated kinaseTubule formationSoluble cell lysateRapid relocalizationPhosphorylation substratesActin cytoskeletonCellular relocalization