Induction of Airway Mucus Production By T Helper 2 (Th2) Cells: A Critical Role For Interleukin 4 In Cell Recruitment But Not Mucus Production
Cohn L, Homer R, Marinov A, Rankin J, Bottomly K. Induction of Airway Mucus Production By T Helper 2 (Th2) Cells: A Critical Role For Interleukin 4 In Cell Recruitment But Not Mucus Production. Journal Of Experimental Medicine 1997, 186: 1737-1747. PMID: 9362533, PMCID: PMC2199146, DOI: 10.1084/jem.186.10.1737.Peer-Reviewed Original ResearchConceptsTh2 cellsMucus productionAirway inflammationIL-4Asthmatic patientsCell recruitmentOVA-specific Th2 cellsT helper 2 cellsIL-4-deficient miceAirway mucus productionOVA-specific TCRRole of Th1CD4 T cellsImportant clinical symptomInduction of inflammationTh2 cell recruitmentCD4 Th1Airway biopsiesClinical symptomsTh1 cellsTNF-alphaT cellsInterleukin-4Effector functionsMucus secretionTranscription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene*
Zhang D, Cohn L, Ray P, Bottomly K, Ray A. Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene*. Journal Of Biological Chemistry 1997, 272: 21597-21603. PMID: 9261181, DOI: 10.1074/jbc.272.34.21597.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsClone CellsDNA-Binding ProteinsDown-RegulationGATA3 Transcription FactorGene Expression Regulation, DevelopmentalHeLa CellsHumansInterleukin-5Lymphocyte ActivationMiceNFATC Transcription FactorsNuclear ProteinsPromoter Regions, GeneticRNA, MessengerSpleenTh1 CellsTh2 CellsTrans-ActivatorsTranscription Factor AP-1Transcription FactorsTranscription, GeneticTranscriptional ActivationUp-RegulationConceptsGene expressionPromoter activationTranscription factor GATA-3Th2 cellsTh1 cellsGATA-3 sitesGATA-3 activityInterleukin-5 geneGATA-3GATA-3 proteinIL-5 promoterIL-5 geneTh2-specific expressionEctopic expressionMolecular basisInterleukin-5T cell receptor transgenic miceT helper 2 cellsReceptor transgenic miceTh2-type cytokinesTreatment of asthmaT helper cellsGATA-3 gene expressionDevelopment of eosinophiliaEL-4 cells